The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains.
Open accessAbstract
The human cytomegalovirus (HCMV) early glycoprotein products of the US11 and US2 open reading frames cause increased turnover of major histocompatibility complex (MHC) class I heavy chains. Since US2 is homologous to another HCMV gene (US3), we hypothesized that the US3 gene product also may affect MHC class I expression. In cells constitutively expressing the HCMV US3 gene, MHC class I heavy chains formed a stable complex with beta 2-microglobulin. However, maturation of the N-linked glycan of MHC class I heavy chains was impaired in US3+ cells. The glycoprotein product of US3 (gpUS3) occurs mostly in a high-mannose form and coimmunoprecipitates with beta 2-microglobulin associated class I heavy chains. Mature class I molecules were detected at steady state on the surface of US3+ cells, as in control cells. Substantial perinuclear accumulation of heavy chains was observed in US3+ cells. The data suggest that gpUS3 impairs egress of MHC class I heavy chains from the endoplasmic reticulum.
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Viral Subversion of the Immune System
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Self-citationThe ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP
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Viral immune evasion: a masterpiece of evolution
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Metadata
- Authors
- Jones, T. R., Wiertz, E. J., Sun, L., Fish, K. N., Nelson, J. A., & Ploegh, H. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-10-15
- Volume
- 93
- Issue
- 21
- Pages
- 11327-11333
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2018841084
- Cited by
- 414
- References
- 33
- FWCI
- 22.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Jones, T. R., Wiertz, E. J., Sun, L., Fish, K. N., Nelson, J. A., & Ploegh, H. L. (1996). Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.21.11327
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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