The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cellular gene expression altered by human cytomegalovirus: Global monitoring with oligonucleotide arrays
Open accessAbstract
Mechanistic insights to viral replication and pathogenesis generally have come from the analysis of viral gene products, either by studying their biochemical activities and interactions individually or by creating mutant viruses and analyzing their phenotype. Now it is possible to identify and catalog the host cell genes whose mRNA levels change in response to a pathogen. We have used DNA array technology to monitor the level of ≈6,600 human mRNAs in uninfected as compared with human cytomegalovirus-infected cells. The level of 258 mRNAs changed by a factor of 4 or more before the onset of viral DNA replication. Several of these mRNAs encode gene products that might play key roles in virus-induced pathogenesis, identifying them as intriguing targets for further study.
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Cites
The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP
Ahn, K., Gruhler, A., Galocha, B., Jones, T. R., Wiertz, E. J. H. J., Ploegh, H. L., Peterson, P. A., Yang, Y., & Früh, K. (1997) · Immunity · doi:10.1016/s1074-7613(00)80349-0 · Cited by 477
Cited by
Antiviral Actions of Interferons
Samuel, C. E. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.4.778-809.2001 · Cited by 2,743
Unique roles of tryptophanyl-tRNA synthetase in immune control and its therapeutic implications
Jin, M. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0196-9 · Cited by 413
Universal DNA microarray method for multiplex detection of low abundance point mutations
Gerry, N. P., Witowski, N. E., Day, J., Hammer, R. P., Barany, G., & Barany, F. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3063 · Cited by 346
Normalization strategies for cDNA microarrays
Schuchhardt, J. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.10.e47 · Cited by 331
Goodrum, F. D., Jordan, C. T., High, K., & Shenk, T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252630899 · Cited by 255
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Metadata
- Authors
- Zhu, H., Cong, J.-P., Mamtora, G., Gingeras, T., & Shenk, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-11-24
- Volume
- 95
- Issue
- 24
- Pages
- 14470-14475
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2054248370
- Cited by
- 444
- References
- 1
- FWCI
- 28.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhu, H., Cong, J.-P., Mamtora, G., Gingeras, T., & Shenk, T. (1998). Cellular gene expression altered by human cytomegalovirus: Global monitoring with oligonucleotide arrays. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.24.14470
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
