The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells.
Open accessAbstract
Hippocampal pyramidal cells, receiving domain specific GABAergic inputs, express up to 10 different subunits of the gamma-aminobutyric acid type A (GABAA) receptor, but only 3 different subunits are needed to form a functional pentameric channel. We have tested the hypothesis that some subunits are selectively located at subsets of GABAergic synapses. The alpha 1 subunit has been found in most GABAergic synapses on all postsynaptic domains of pyramidal cells. In contrast, the alpha 2 subunit was located only in a subset of synapses on the somata and dendrites, but in most synapses on axon initial segments innervated by axo-axonic cells. The results demonstrate that molecular specialization in the composition of postsynaptic GABAA receptor subunits parallels GABAergic cell specialization in targeting synapses to a specific domain of postsynaptic cortical neurons.
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Metadata
- Authors
- Nusser, Z., Sieghart, W., Benke, D., Fritschy, J. M., & Somogyi, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-10-15
- Volume
- 93
- Issue
- 21
- Pages
- 11939-11944
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2031872972
- Cited by
- 384
- References
- 11
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Nusser, Z., Sieghart, W., Benke, D., Fritschy, J. M., & Somogyi, P. (1996). Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.21.11939
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.