The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Phosphorylation of synaptic vesicle proteins: modulation of the alpha SNAP interaction with the core complex.
Open accessAbstract
We analyzed whether synaptic membrane trafficking proteins are substrates for casein kinase II, calcium/calmodulin-dependent protein kinase II, and cAMP-dependent protein kinase (PKA), three kinases implicated in the modulation of synaptic transmission. Each kinase phosphorylates a specific set of the vesicle proteins syntaxin 1A, N-ethylmaleimide-sensitive factor (NSF), vesicle-associated membrane protein (VAMP), synaptosome-associated 25-kDa protein (SNAP-25), n-sec1, alpha soluble NSF attachment protein (alpha SNAP), and synaptotagmin. VAMP is phosphorylated by calcium/calmodulin-dependent protein kinase II on serine 61. alpha SNAP is phosphorylated by PKA; however, the beta SNAP isoform is phosphorylated only 20% as efficiently. alpha SNAP phosphorylated by PKA binds to the core docking and fusion complex 10 times weaker than the dephosphorylated form. These studies provide a first glimpse at regulatory events that may be important in modulating neurotransmitter release during learning and memory.
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Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Stevens, C. F., Tonegawa, S., & Wang, Y. (1992) · Science · doi:10.1126/science.1378648 · Cited by 1,472
Mediation of Hippocampal Mossy Fiber Long-Term Potentiation by Cyclic AMP
Weisskopf, M. G., Castillo, P. E., Zalutsky, R. A., & Nicoll, R. A. (1994) · Science · doi:10.1126/science.7916482 · Cited by 618
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Metadata
- Authors
- Hirling, H., & Scheller, R. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-10-15
- Volume
- 93
- Issue
- 21
- Pages
- 11945-11949
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1972977742
- Cited by
- 181
- References
- 2
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Hirling, H., & Scheller, R. H. (1996). Phosphorylation of synaptic vesicle proteins: modulation of the alpha SNAP interaction with the core complex. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.21.11945
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