The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Activation of memory circuits during cue-elicited cocaine craving.
Open accessAbstract
Evidence accumulated over more than 45 years has indicated that environmental stimuli can induce craving for drugs of abuse in individuals who have addictive disorders. However, the brain mechanisms that subserve such craving have not been elucidated. Here a positron emission tomographic study shows increased glucose metabolism in cortical and limbic regions implicated in several forms of memory when human volunteers who abuse cocaine are exposed to drug-related stimuli. Correlations of metabolic increases in the dorsolateral prefrontal cortex, medial temporal lobe (amygdala), and cerebellum with self-reports of craving suggest that a distributed neural network, which integrates emotional and cognitive aspects of memory, links environmental cues with cocaine craving.
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Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340
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Metadata
- Authors
- Grant, S., London, E. D., Newlin, D. B., Villemagne, V. L., Liu, X., Contoreggi, C., Phillips, R. L., Kimes, A. S., & Margolin, A.
- Affiliations
- National Institute on Drug Abuse (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1996-10-15
- Volume
- 93
- Issue
- 21
- Pages
- 12040-12045
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC38179
- OpenAlex
- W2022235619
- Cited by
- 936
- References
- 38
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 16 · 2023: 18 · 2022: 9 · 2021: 18 · 2020: 17 · 2019: 19 · 2018: 27 · 2017: 30 · 2016: 28 · 2015: 35 · 2014: 30 · 2013: 54 · 2012: 27
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- cocaine craving, drug-related cues, memory circuits, cocaine dependence, glucose metabolism, dorsolateral prefrontal cortex, amygdala, medial temporal lobe, cerebellum, emotional memory, cognitive memory, cue reactivity, artificial neural networks
- MeSH terms
- Adult, Analysis of Variance, Brain, Cocaine, Deoxyglucose, Female, Fluorine Radioisotopes, Glucose, Humans, Functional Laterality, Male, Memory, Opioid-Related Disorders, Tomography, Emission-Computed, Fluorodeoxyglucose F18, Substance-Related Disorders
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