The N-end rule: functions, mysteries, uses

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Items 101–200 of 856

1. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes
   Nabila Aboulaich, Julia P. Vainonen, Peter Strålfors, Alexander V. Vener · 2004 · Biochemical Journal
2. RGS4 Is Arginylated and Degraded by the N-end Rule Pathway in Vitro
   Ilia V. Davydov, Alexander J. Varshavsky · 2000 · Journal of Biological Chemistry
3. The E2–E3 interaction in the N‐end rule pathway: the RING‐H2 finger of E3 is required for the synthesis of multiubiquitin chain
   Youming Xie, Alexander J. Varshavsky · 1999 · The EMBO Journal
4. Control of protein life‐span by N‐terminal methionine excision
   Carmela Giglione, Olivier Vallon, Thierry Meinnel · 2002 · The EMBO Journal
5. Interaction between RGS7 and polycystin
   Emily Kim, Thierry Arnould, Lorenz K. Sellin, Thomas R. Benzing, Natalia Comella, Olivier N. Kocher, Leonidas Tsiokas, Vikas P. Sukhatme, Gerd Walz · 1999 · Proceedings of the National Academy of Sciences
6. A battle for iron: host sequestration and Staphylococcus aureus acquisition
   Haley, Kathryn P., Skaar, Eric P. · 2012 · Microbes and Infection
7. Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway
   Sang-Eun Park, Jeong‐Mok Kim, Ok-Hee Seok, Hanna Cho, Brandon C. Wadas, Seon‐Young Kim, Alexander J. Varshavsky, Cheol-Sang Hwang · 2015 · Science
8. Precise quantification of translation inhibition by mRNA structures that overlap with the ribosomal footprint in N-terminal coding sequences
   Amin Espah Borujeni, Daniel P. Cetnar, Iman Farasat, Ashlee Smith, Natasha Lundgren, Howard M. Salis · 2017 · Nucleic Acids Research
9. Toxin-Based Therapeutic Approaches
   Assaf Shapira, Itai Benhar · 2010 · Toxins
10. Clp‐mediated proteolysis in Gram‐positive bacteria is autoregulated by the stability of a repressor
    Elke Krüger, Daniela Zühlke, Elke Witt, Holger Ludwig, Michael Hecker · 2001 · The EMBO Journal
11. Construction and Analysis of Mouse Strains Lacking the Ubiquitin Ligase UBR1 (E3α) of the N-End Rule Pathway
    Yong Tae Kwon, Zanxian Xia, Ilia V. Davydov, Stewart H. Lecker, Alexander J. Varshavsky · 2001 · Molecular and Cellular Biology
12. Rates of ubiquitin conjugation increase when muscles atrophy, largely through activation of the N-end rule pathway
    Vered Solomon, Vickie Elaine Baracos, Pasha Sarraf, Alfred Lewis Goldberg · 1998 · Proceedings of the National Academy of Sciences
13. A cloning method to identify caspases and their regulators in yeast: Identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1
    Christine J. Hawkins, Susan L. Wang, Bruce A. Hay · 1999 · Proceedings of the National Academy of Sciences
14. An oncolytic adenoviral vector of Smac increases antitumor activity of TRAIL against HCC in human cells and in mice
    Zifei Pei, Liang Chu, Weiguo Zou, Zilai Zhang, Songbo Qiu, Rong Qi, Jinfa Gu, Cheng Qian, Xinyuan Liu · 2004 · Hepatology
15. Integrated transcriptome and proteome data: The challenges ahead
    Catherine Jane Hack · 2004 · Briefings in Functional Genomics and Proteomics
16. Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases
    Woo Suk Choi, Byung‐Cheon Jeong, Yoo Jin Joo, Myeong-Ryeol Lee, Joon Kim, Michael J. Eck, Hyun Kyu Song · 2010 · Nature Structural & Molecular Biology
17. The Substrate Recognition Domains of the N-end Rule Pathway
    Tasaki, Takafumi, Zakrzewska, Adriana, Dudgeon, Drew D., Jiang, Yonghua, Lazo, John S., Kwon, Yong Tae · 2009 · Journal of Biological Chemistry
18. A delayed leaf senescence mutant is defective in arginyl‐tRNA:protein arginyltransferase, a component of the N‐end rule pathway in Arabidopsis
    Satoko Yoshida, Masaki A. Ito, Judy Callis, Ikuo Nishida, Akira Watanabe · 2002 · The Plant Journal
19. The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases
    Cheol‐Sang Hwang, Anna Shemorry, Daniel Auerbach, Alexander J. Varshavsky · 2010 · Nature Cell Biology
20. Proteomics-based Target Identification
    Harry Towbin, Kenneth W. Bair, James A. DeCaprio, Michael J. Eck, Sunkyu Kim, Frederick R. Jr. Kinder, Anthony A. Morollo, Dieter R. Mueller, Patrick A. Schindler, Hyun Kyu Song et al. · 2003 · Journal of Biological Chemistry
21. Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system
    Guharoy, Mainak, Bhowmick, Pallab, Sallam, Mohamed, Tompa, Peter · 2016 · Nature Communications
22. Female Lethality and Apoptosis of Spermatocytes in Mice Lacking the UBR2 Ubiquitin Ligase of the N-End Rule Pathway
    Yong Tae Kwon, Zanxian Xia, Jee Young An, Takafumi Tasaki, Ilia V. Davydov, Jai Wha Seo, Jun Sheng, Youming Xie, Alexander J. Varshavsky · 2003 · Molecular and Cellular Biology
23. The ubiquitin-proteasome pathway as a therapeutic target for muscle wasting.
    Michael John Tisdale · 2005 · PubMed
24. Orchestrating anaphase and mitotic exit: separase cleavage and localization of Slk19
    Matthew Sullivan, Christine Lehane, Frank Uhlmann · 2001 · Nature Cell Biology
25. The N-terminal to C-terminal motif in protein folding and function
    Krishna M.G. Mallela, S. Walter Englander · 2005 · Proceedings of the National Academy of Sciences
26. Disparity between changes in mRNA abundance and enzyme activity in Corynebacterium glutamicum: implications for DNA microarray analysis
    Christoph Glanemann, A. Loos, Nathalie Gorret, Laura B. Willis, Xian M. O’Brien, Philip A. Lessard, Anthony J. Sinskey · 2002 · Applied Microbiology and Biotechnology
27. New aspects of altitude adaptation in Tibetans: a proteomic approach
    Cecilia Gelfi, Sara De Palma, Marilena Ripamonti, Robin Wait, Ivano Eberini, Ashok Bajracharya, Claudio Marconi, Adrian Schneider, Hans H. Hoppeler, P. Cerretelli · 2004 · The FASEB Journal
28. Synthesis/Degradation Ratio Mass Spectrometry for Measuring Relative Dynamic Protein Turnover
    Benjamin J. Cargile, Jonathan L. Bundy, Amy Michele Grunden, James L. Stephenson · 2003 · Analytical Chemistry
29. Controlled destruction: AAA+ ATPases in protein degradation from bacteria to eukaryotes
    Frank Striebel, Wolfgang Kress, Eilika U. Weber-Ban · 2009 · Current Opinion in Structural Biology
30. The Human Lysyl-tRNA Synthetase Gene Encodes Both the Cytoplasmic and Mitochondrial Enzymes by Means of an Unusual Alternative Splicing of the Primary Transcript
    Elena N. Tolkunova, Hye Jeong Park, Jun Xia, Michael P. King, Edgar Davidson · 2000 · Journal of Biological Chemistry
31. Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1
    Peter Kaiser, Rey A. L. Sia, Elaine S.G. Bardes, Daniel J. Lew, Steven I. Reed · 1998 · Genes & Development
32. The Clp protease system; a central component of the chloroplast protease network
    Paul Dominic B. Olinares, Jitae Kim, Klaas Jan van Wijk · 2010 · Biochimica et Biophysica Acta (BBA) - Bioenergetics
33. Polyamines regulate their synthesis by inducing expression and blocking degradation of ODC antizyme
    R. Palanimurugan, Hartmut Scheel, Kay Hofmann, R. Jürgen Dohmen · 2004 · The EMBO Journal
34. Identification of a Calmodulin-binding NAC Protein as a Transcriptional Repressor in Arabidopsis
    Ho Soo Kim, Byung Ouk Park, Jae Hyuk Yoo, Mi Soon Jung, Sang Min Lee, Hay Ju Han, Kyung Eun Kim, Sun Ho Kim, Chae Oh Lim, Dae‐Jin Yun et al. · 2007 · Journal of Biological Chemistry
35. The ubiquitin‐specific protease UBP14 is essential for early embryo development in Arabidopsis thaliana
    Jed H. Doelling, Ning Yan, Jasmina Kurepa, Joseph M. Walker, Richard David Vierstra · 2001 · The Plant Journal
36. Attenuation of Zinc Finger Nuclease Toxicity by Small-Molecule Regulation of Protein Levels
    Shondra M. Pruett‐Miller, David W. Reading, Shaina N. Porter, Matthew Hebden Porteus · 2009 · PLoS Genetics
37. The N-end Rule Pathway Catalyzes a Major Fraction of the Protein Degradation in Skeletal Muscle
    Vered Solomon, Stewart H. Lecker, Alfred Lewis Goldberg · 1998 · Journal of Biological Chemistry
38. E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6
    Richard G. Hibbert, Anding Huang, Rolf Boelens, Titia K. Sixma · 2011 · Proceedings of the National Academy of Sciences
39. Scalable inference of heterogeneous reaction kinetics from pooled single-cell recordings
    Christoph Zechner, M. Unger, Serge B. Pelet, Matthias Peter, Heinz Koeppl · 2014 · Nature Methods
40. A squalene synthase protein degradation method for improved sesquiterpene production in Saccharomyces cerevisiae
    Bingyin Peng, Manuel R. Plan, Panagiotis K. Chrysanthopoulos, Mark P. Hodson, Lars Keld Nielsen, Claudia Estelle Vickers · 2016 · Metabolic Engineering
41. Clp chaperone–proteases: structure and function
    Wolfgang Kress, Željka Maglica, Eilika U. Weber-Ban · 2009 · Research in Microbiology
42. Evidence for Direct Interaction between Sprouty and Cbl
    Esther Sook Miin Wong, Jormay Lim, Boon Chuan Low, Qiping Chen, Graeme R. Guy · 2001 · Journal of Biological Chemistry
43. The mysteries of nitrogen balance
    John Conrad Waterlow · 1999 · Nutrition Research Reviews
44. Listeriolysin O: a key protein ofListeria monocytogeneswith multiple functions
    Samer Kayal, Alain Charbit · 2006 · FEMS Microbiology Reviews
45. Plasma membrane localization signals in the light chain of botulinum neurotoxin
    Ester Fernández‐Salas, Lance E. Steward, Helen Ho, Patton E. Garay, Sarah W. Sun, Marcella A. Gilmore, Joseph V. Ordas, Joanne Wang, Joseph Francis, Kei Roger Aoki · 2004 · Proceedings of the National Academy of Sciences
46. Production of plant proteases in vivo and in vitro — A review
    González-Rábade, Nuria, Badillo-Corona, Jesús Agustín, Aranda-Barradas, Juan Silvestre, Oliver-Salvador, María del Carmen · 2011 · Biotechnology Advances
47. The N‐end rule pathway controls the import of peptides through degradation of a transcriptional repressor
    Christopher Byrd, Glenn C Turner, Alexander J. Varshavsky · 1998 · The EMBO Journal
48. Arabidopsis COP10 is a ubiquitin-conjugating enzyme variant that acts together with COP1 and the COP9 signalosome in repressing photomorphogenesis
    Genki Suzuki, Yuki Yanagawa, Shing F. Kwok, Minami Matsui, Xing‐Wang Deng · 2002 · Genes & Development
49. Fluorescent probes for proteolysis: Tools for drug discovery
    Jacques Neefjes, Nico P. Dantuma · 2004 · Nature Reviews Drug Discovery
50. Microarray-based analysis of fish egg quality after natural or controlled ovulation
    Émilie Bonnet, Alexis Fostier, Julien Bobe · 2007 · BMC Genomics
51. Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics
    Mona D. Lee, Yuhong She, Michael J. Soskis, Christopher P. Borella, Jeffrey R. Gardner, Paula A. Hayes, Benzon M. Dy, Mark Lawrence Heaney, Mark R. Philips, William G. Bornmann et al. · 2004 · Journal of Clinical Investigation
52. Identification of Novel ErbB3-Interacting Factors Using the Split-Ubiquitin Membrane Yeast Two-Hybrid System
    Safia Thaminy, Daniel Auerbach, Anthony Arnoldo, Igor Štagljar · 2003 · Genome Research
53. Kendrin Is a Novel Substrate for Separase Involved in the Licensing of Centriole Duplication
    Kazuhiko Matsuo, Keita Ohsumi, Mari Iwabuchi, Toshio Kawamata, Yoshitaka Ono, Mikiko Takahashi · 2012 · Current Biology
54. Seamless cloning and gene fusion
    Quinn Lu · 2005 · Trends in biotechnology
55. ClpS1 Is a Conserved Substrate Selector for the Chloroplast Clp Protease System in Arabidopsis
    Kenji J. Nishimura, Y. Asakura, Giulia Friso, J. Kim, S.-h. Oh, Heidi L. Rutschow, Lalit Ponnala, Klaas Jan van Wijk · 2013 · The Plant Cell
56. The N-end rule pathway controls multiple functions during Arabidopsis shoot and leaf development
    Emmanuelle Graciet, Franziska Walter, Diarmuid S. Ó’Maoiléidigh, Stephan Pollmann, Elliot M. Meyerowitz, Alexander J. Varshavsky, Frank Wellmer · 2009 · Proceedings of the National Academy of Sciences
57. Spatiotemporal Regulation of c-Fos by ERK5 and the E3 Ubiquitin Ligase UBR1, and Its Biological Role
    Takanori Sasaki, Hirotada Kojima, Rikiya Kishimoto, Ayu Ikeda, Hiroyuki Kunimoto, Koich Nakajima · 2006 · Molecular Cell
58. Efficient genetic modification of murine dendritic cells by electroporation with mRNA
    Sonja Van Meirvenne, Lieven Straetman, Carlo Heirman, Mélissa Dullaers, Catherine De Greef, Viggo F. Van Tendeloo, Kris Thielemans · 2002 · Cancer Gene Therapy
59. Degradation signals in the lysine–asparagine sequence space
    Takashi Suzuki, Alexander J. Varshavsky · 1999 · The EMBO Journal
60. The N-end rule pathway is a sensor of heme
    Ronggui Hu, Haiqing Wang, Zanxian Xia, Alexander J. Varshavsky · 2007 · Proceedings of the National Academy of Sciences
61. The autotransporter secretion system
    Mickaël Desvaux, Nicholas J. Parham, Ian R. Henderson · 2003 · Research in Microbiology
62. The UBA2 Domain Functions as an Intrinsic Stabilization Signal that Protects Rad23 from Proteasomal Degradation
    Stijn Heessen, Maria Grazia Masucci, Nico P. Dantuma · 2005 · Molecular Cell
63. Identification of protein stability determinants in chloroplasts
    Wiebke Apel, Waltraud X. Schulze, Ralph Bock · 2010 · The Plant Journal
64. Assembly of Alphavirus Replication Complexes from RNA and Protein Components in a Novel trans -Replication System in Mammalian Cells
    Pirjo Spuul, Giuseppe Balistreri, Kirsi Hellström, Andrey Golubtsov, Eija Jokitalo, Tero Ahola · 2011 · Journal of Virology
65. Bacterial infectious disease control by vaccine development
    Roy Curtiss · 2002 · Journal of Clinical Investigation
66. Evolution of Peptidase Diversity
    Michael J. Page, Enrico Di · 2008 · Journal of Biological Chemistry
67. Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway
    Dong, Cheng, Zhang, Heng, Li, Li, Tempel, Wolfram, Loppnau, Peter, Min, Jinrong · 2018 · Nature Chemical Biology
68. Regulation of Protein Catabolism by Muscle-Specific and Cytokine-Inducible Ubiquitin Ligase E3α-II during Cancer Cachexia
    Keith S. Kwak, Xiaolan Zhou, Vered Solomon, Vickie Elaine Baracos, James G. Davis, Anthony W. Bannon, William J. Boyle, David L. Lacey, H.Q. Han · 2004 · Cancer Research
69. The N-end rule pathway: From recognition by N-recognins, to destruction by AAA+proteases
    David A. Dougan, Dimce Micevski, Kaye N. Truscott · 2011 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
70. Variations in the association of papillomavirus E2 proteins with mitotic chromosomes
    Jaquelline Germano de Oliveira, Leremy A. Colf, Alison A. McBride · 2006 · Proceedings of the National Academy of Sciences
71. The 2′,5′-Oligoadenylate Synthetase 1b Is a Potent Inhibitor of West Nile Virus Replication Inside Infected Cells
    Anna Kajaste‐Rudnitski, Tomoji Mashimo, Marie‐Pascale Frenkiel, Jean‐Louis Guénet, Marianne Lucas‐Hourani, Philippe Desprès · 2005 · Journal of Biological Chemistry
72. Regulation by proteolysis: Developmental switches
    Susan Gottesman · 1999 · Current Opinion in Microbiology
73. Altered Activity, Social Behavior, and Spatial Memory in Mice Lacking the NTAN1p Amidase and the Asparagine Branch of the N-End Rule Pathway
    Yong Tae Kwon, Seth A. Balogh, Ilia V. Davydov, Anna S. Kashina, Jeong Kyo Yoon, Youming Xie, Arti B Gaur, Lynn A. Hyde, Victor H. Denenberg, Alexander J. Varshavsky · 2000 · Molecular and Cellular Biology
74. Effect of a pyruvate kinase (pykF-gene) knockout mutation on the control of gene expression and metabolic fluxes in Escherichia coli
    Khandaker Siddiquee, Marcos J. Arauzo-Bravo, Kazuyuki Shimizu · 2004 · FEMS Microbiology Letters
75. Intracellular targeting of the proteasome
    Christian Hirsch, Hidde L. Ploegh · 2000 · Trends in Cell Biology
76. Organellar peptide deformylases: universality of the N-terminal methionine cleavage mechanism
    Carmela Giglione, Thierry Meinnel · 2001 · Trends in Plant Science
77. Multiplicity and regulation of genes encoding peptide transporters in Saccharomyces cerevisiae
    Melinda Hauser, Vanny Narita, Amy M. Donhardt, Fred R. Naider, Jeffrey M. Becker · 2001 · Molecular Membrane Biology
78. Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain
    Fangyong Du, Federico Navarro, Zanxian Xia, Takafumi Tasaki, Alexander J. Varshavsky · 2002 · Proceedings of the National Academy of Sciences
79. Ubiquitin Fusion Technique and Related Methods
    Alexander J. Varshavsky · 2005 · Methods in enzymology on CD-ROM/Methods in enzymology
80. The bacterial N-end rule pathway: expect the unexpected
    David A. Dougan, Kaye N. Truscott, Kornelius Zeth · 2010 · Molecular Microbiology
81. RECQL4, mutated in the Rothmund–Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway
    Jinhu Yin, Yong Tae Kwon, Alexander J. Varshavsky, Weidong Wang · 2004 · Human Molecular Genetics
82. A new screen for protein interactions reveals that the Saccharomyces cerevisiae high mobility group proteins Nhp6A/B are involved in the regulation of the GAL1 promoter
    Heike Laser, Christine Bongards, Jutta Schüller, Stephanie Heck, Nils Johnsson, Norbert Lehming · 2000 · Proceedings of the National Academy of Sciences
83. Two F‐box/WD‐repeat proteins Pop1 and Pop2 form hetero‐ and homo‐complexes together with cullin‐1 in the fission yeast SCF (Skp1‐Cullin‐1‐F‐box) ubiquitin ligase
    Kin‐ichiro Kominami, Itziar Ochotorena, Takashi Toda · 1998 · Genes to Cells
84. Substrate-binding Sites of UBR1, the Ubiquitin Ligase of the N-end Rule Pathway
    Zanxian Xia, Ailsa Webster, Fangyong Du, Konstantin I. Piatkov, Michel Ghislain, Alexander J. Varshavsky · 2008 · Journal of Biological Chemistry
85. Antifungal Activities of Antineoplastic Agents: Saccharomyces cerevisiae as a Model System To Study Drug Action
    Maria Elena Cardenas, Maria Cristina Cruz, Maurizio Del Poeta, Namjin Chung, John R. Perfect, Joseph Heitman · 1999 · Clinical Microbiology Reviews
86. Ube2W conjugates ubiquitin to α-amino groups of protein N-termini
    Michael H. Tatham, Anna Plechanovová, Ellis Jaffray, Helena Salmen, Ronald T. Hay · 2013 · Biochemical Journal
87. The N-end rule and regulation of apoptosis
    Alexander J. Varshavsky · 2003 · Nature Cell Biology
88. Posttranslational Control of ALA Synthesis Includes GluTR Degradation by Clp Protease and Stabilization by GluTR-Binding Protein
    Janina Apitz, Kenji J. Nishimura, Judith Schmied, Anja A. Wolf, Boris Hedtke, Klaas Jan van Wijk, Bernhard Grimm · 2016 · PLANT PHYSIOLOGY
89. Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles
    Gerhard Multhaup, Otmar Huber, Luc Buée, Marie‐Christine Galas · 2015 · Journal of Biological Chemistry
90. Srb7p is a physical and physiological target of Tup1p
    Anne Gromöller, Norbert Lehming · 2000 · The EMBO Journal
91. N-Terminal Residues Control Proteasomal Degradation of RGS2, RGS4, and RGS5 in Human Embryonic Kidney 293 Cells
    Johannes Bodenstein, Roger K. Sunahara, Richard R. Neubig · 2007 · Molecular Pharmacology
92. The plant N-end rule pathway: structure and functions
    Emmanuelle Graciet, Frank Wellmer · 2010 · Trends in Plant Science
93. Polycistronic Viral Vectors
    Pablo de Felipe · 2002 · Current Gene Therapy
94. Selective inhibition of amino-terminal methionine processing by TNP-470 and ovalicin in endothelial cells
    Benjamin E. Turk, Eric C. Griffith, Susan Wolf, KLAUS BIEMANN, Yie‐Hwa Chang, Jun O. Liu · 1999 · Chemistry & Biology
95. N-terminal Protein Processing: A Comparative Proteogenomic Analysis
    Stefano R. Bonissone, Nitin Gupta, Margaret F. Romine, Ralph A. Bradshaw, Pavel A. Pevzner · 2012 · Molecular & Cellular Proteomics
96. Discovery of Cellular Regulation by Protein Degradation
    Alexander J. Varshavsky · 2008 · Journal of Biological Chemistry
97. The products of the yeast MMS2 and two human homologs (hMMS2 and CROC- 1) define a structurally and functionally conserved Ubc-like protein family
    Wei Xiao · 1998 · Nucleic Acids Research
98. DNA Vaccination against Tuberculosis: Expression of a Ubiquitin-Conjugated Tuberculosis Protein Enhances Antimycobacterial Immunity
    Giovanni Delogu, Angela D. Howard, Frank M. Collins, Sheldon L. Morris · 2000 · Infection and Immunity
99. Multiubiquitin Chain Binding Subunit MCB1 (RPN10) of the 26S Proteasome Is Essential for Developmental Progression in Physcomitrella patens
    Pierre‐Alain Girod, Hongyong Fu, Jean‐Pierre Zrÿd, Richard David Vierstra · 1999 · The Plant Cell
100. The early history of the ubiquitin field
     Alexander J. Varshavsky · 2006 · Protein Science