The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Foldons, protein structural modules, and exons.
Open accessAbstract
Foldons, which are kinetically competent, quasi-independently folding units of a protein, may be defined using energy landscape analysis. Foldons can be identified by maxima in a scan of the ratio of a contiguous segment's energetic stability gap to the energy variance of that segment's molten globule states, reflecting the requirement of minimal frustration. The predicted foldons are compared with the exons and structural modules for 16 of the 30 proteins studied. Statistical analysis indicates a strong correlation between the energetically determined foldons and Go's geometrically defined structural modules, but there are marked sequence-dependent effects. There is only a weak correlation of foldons to exons. For gammaII-crystallin, myoglobin, barnase, alpha-lactalbumin, and cytochrome c the foldons and some noncontiguous clusters of foldons compare well with intermediates observed in experiment.
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Cites
Funnels, pathways, and the energy landscape of protein folding: A synthesis
Bryngelson, J. D., Onuchic, J. N., Socci, N. D., & Wolynes, P. G. (1995) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.340210302 · Cited by 2,648
Self-citationGilbert, W. (1978) · Nature · doi:10.1038/271501a0 · Cited by 2,300
Toward an outline of the topography of a realistic protein-folding funnel.
Onuchic, J. N., Wolynes, P. G., Luthey-Schulten, Z., & Socci, N. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3626 · Cited by 523
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Cited by
THEORY OF PROTEIN FOLDING: The Energy Landscape Perspective
Onuchic, J. N., Luthey-Schulten, Z., & Wolynes, P. G. (1997) · Annual Review of Physical Chemistry · doi:10.1146/annurev.physchem.48.1.545 · Cited by 2,210
Self-citationNucleation mechanisms in protein folding
Fersht, A. R. (1997) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(97)80002-4 · Cited by 545
Molecular Simulation of ab Initio Protein Folding for a Millisecond Folder NTL9(1−39)
Voelz, V. A., Bowman, G. R., Beauchamp, K., & Pande, V. S. (2010) · Journal of the American Chemical Society · doi:10.1021/ja9090353 · Cited by 503
Folding and binding cascades: Shifts in energy landscapes
Tsai, C.-J., Ma, B., & Nussinov, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.9970 · Cited by 365
Ferreiro, D. U., Komives, E. A., & Wolynes, P. G. (2014) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583514000092 · Cited by 314
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Metadata
- Authors
- Panchenko, A. R., Luthey-Schulten, Z., & Wolynes, P. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-03-05
- Volume
- 93
- Issue
- 5
- Pages
- 2008-2013
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1971135687
- Cited by
- 170
- References
- 3
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Panchenko, A. R., Luthey-Schulten, Z., & Wolynes, P. G. (1996). Foldons, protein structural modules, and exons. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.5.2008
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