The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: activation of the vertebrate homologue of the drosophila seven in absentia gene.
Open accessAbstract
We report the isolation of 10 differentially expressed cDNAs in the process of apoptosis induced by the p53 tamor suppressor. As a global analytical method, we performed a differential display of mRNA between mouse M1 myeloid leukemia cells and derived clone LTR6 cells, which contain a stably transfected temperature-sensitive mutant of p53. At 32 degrees C wild-type p53 function is activated in LTR6 cells, resulting in programmed cell death. Eight genes are activated (TSAP; tumor suppressor activated pathway), and two are inhibited (TSIP, tumor suppressor inhibited pathway) in their expression. None of the 10 sequences has hitherto been recognized as part of the p53 signaling pathway. Three TSAPs are homologous to known genes. TSAP1 corresponds to phospholipase C beta 4. TSAP2 has a conserved domain homologous to a multiple endocrine neoplasia I (ZFM1) candidate gene. TSAP3 is the mouse homologue of the Drosophila seven in absentia gene. These data provide novel molecules involved in the pathway of wild-type p53 activation. They establish a functional link between a homologue of a conserved developmental Drosophila gene and signal transduction in tumor suppression leading to programmed cell death.
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Citations
Cites
p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
The p53 proto-oncogene can act as a suppressor of transformation
Finlay, C. A., Hinds, P. W., & Levine, A. J. (1989) · Cell · doi:10.1016/0092-8674(89)90045-7 · Cited by 1,987
Cyclin G is a transcriptional target of the p53 tumor suppressor protein.
Okamoto, K., & Beach, D. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06807.x · Cited by 455
Cited by
Deadly encounter: ubiquitin meets apoptosis
Jesenberger, V., & Jentsch, S. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm731 · Cited by 355
Metadata
- Authors
- Amson, R. B., Nemani, M., Roperch, J. P., Israeli, D., Bougueleret, L., Le Gall, I., Medhioub, M., Linares-Cruz, G., Lethrosne, F., Pasturaud, P., Piouffre, L., Prieur, S., Susini, L., Alvaro, V, Millasseau, P., Guidicelli, C., Bui, H., Massart, C., Cazes, L., Dufour, F., Bruzzoni-Giovanelli, H., Owadi, H., Hennion, C., Charpak, G., & Telerman, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-04-30
- Volume
- 93
- Issue
- 9
- Pages
- 3953-3957
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2085356240
- Cited by
- 163
- References
- 5
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Amson, R. B., Nemani, M., Roperch, J. P., Israeli, D., Bougueleret, L., Le Gall, I., Medhioub, M., Linares-Cruz, G., Lethrosne, F., Pasturaud, P., Piouffre, L., Prieur, S., Susini, L., Alvaro, V, Millasseau, P., Guidicelli, C., Bui, H., Massart, C., Cazes, L., . . . Telerman, A. (1996). Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: activation of the vertebrate homologue of the drosophila seven in absentia gene. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.9.3953
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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