The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
β cell apoptosis in T cell-mediated autoimmune diabetes
Open accessAbstract
Insulin-dependent diabetes mellitus results from T cell-mediated destruction of insulin-producing, pancreatic islet β cells. How this destruction takes place has remained elusive—largely due to the slow kinetics of disease progression. By crossing a transgenic mouse carrying a β cell-specific T cell receptor onto the NOD. scid background, we produced a simplified but robust and accelerated model of diabetes. This mouse produces CD4 + T cells bearing transgenic T cell receptor but is devoid of CD8 + T cells and B cells. More importantly, this mouse develops a rapid diabetes, which has allowed us to record and quantify β cell death. We have determined that β cells within the inflamed islets die by apoptosis.
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Cites
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Pharmacological and Clinical Aspects of Heme Oxygenase
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Autoimmune Destruction of Pancreatic β Cells
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Metadata
- Authors
- Kurrer, M. O., Pakala, S. V., Hanson, H. L., & Katz, J. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-01-07
- Volume
- 94
- Issue
- 1
- Pages
- 213-218
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2052439818
- Cited by
- 320
- References
- 45
- FWCI
- 14.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Kurrer, M. O., Pakala, S. V., Hanson, H. L., & Katz, J. D. (1997). β cell apoptosis in T cell-mediated autoimmune diabetes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.1.213
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
