The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain
Open accessAbstract
The N-terminal ≈440 aa of integrin α subunits contain seven sequence repeats. These are predicted here to fold into a β-propeller domain. A homologous domain from the enzyme phosphatidylinositol phospholipase D is predicted to have the same fold. The domains contain seven four-stranded β-sheets arranged in a torus around a pseudosymmetry axis. The trimeric G-protein β subunit (G beta) appears to be the most closely related β-propeller. Integrin ligands and a putative Mg 2+ ion are predicted to bind to the upper face of the β-propeller. This face binds substrates in β-propeller enzymes and is used by the G protein β subunit to bind the G protein α subunit. The integrin α subunit I domain, which is structurally homologous to the G protein α subunit, is tethered to the top of the β-propeller domain by a hinge that may allow movement of the domains relative to one another. The Ca 2+ -binding motifs in integrin α subunits are on the lower face of the β-propeller.
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Citations
Cites
Kabsch, W., & Sander, C. (1983) · Biopolymers · doi:10.1002/bip.360221211 · Cited by 15,320
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
Self-citationA new approach to protein fold recognition
Jones, D. T., Taylort, W. R., & Thornton, J. M. (1992) · Nature · doi:10.1038/358086a0 · Cited by 1,221
Cited by
Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606
Plow, E. F., Haas, T. A., Zhang, L., Loftus, J., & Smith, J. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000003200 · Cited by 1,356
Aplin, A. E., Howe, A., Alahari, S. K., & Juliano, R. L. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01359-0 · Cited by 847
Lymphocyte Trafficking and Regional Immunity
(1999) · Advances in Immunology · doi:10.1016/s0065-2776(08)60022-x · Cited by 674
Integrin Signaling: The Platelet Paradigm
Shattil, S. J., Kashiwagi, H., & Pampori, N. (1998) · Blood · doi:10.1182/blood.v91.8.2645.2645_2645_2657 · Cited by 665
Metadata
- Authors
- Springer, T. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-01-07
- Volume
- 94
- Issue
- 1
- Pages
- 65-72
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1550140963
- Cited by
- 418
- References
- 3
- FWCI
- 18.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Springer, T. A. (1997). Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.1.65
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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