The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis
Open accessAbstract
The partial molecular characterization of multiple sclerosis (MS)-associated retrovirus (MSRV), a novel retrovirus previously called LM7, is reported. MSRV has been isolated repeatedly from leptomeningeal, choroid plexus and from Epstein–Barr virus-immortalized B cells of MS patients. A strategy based on reverse transcriptase PCR with RNA-purified extracellular virions yielded an initial pol fragment from which other regions of the retroviral genome were subsequently obtained by sequence extension. MSRV-specific PCR primers amplified a pol region from RNA present at the peak of reverse transcriptase activity, coinciding with extracellular viral particles in sucrose density gradients. The same sequence was detected in noncellular RNA from MS patient plasma and in cerebrospinal fluid from untreated MS patients. MSRV is related to, but distinct from, the endogenous retroviral sequence ERV9. Whether MSRV represents an exogenous retrovirus with closely related endogenous elements or a replication-competent, virion-producing, endogenous provirus is as yet unknown. Further molecular epidemiological studies are required to determine precisely the apparent association of virions containing MSRV RNA with MS.
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Cited by
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Metadata
- Authors
- Perron, H., Garson, J. A., Bedin, F., Beseme, F., Paranhos-Baccala, G., Komurian-Pradel, F., Mallet, F., Tuke, P. W., Voisset, C., Blond, J. L., Lalande, B., Seigneurin, J. M., Mandrand, B., & Sclerosis, T. C. R. G. O. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-07-08
- Volume
- 94
- Issue
- 14
- Pages
- 7583-7588
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2017749542
- Cited by
- 484
- References
- 29
- FWCI
- 18.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Perron, H., Garson, J. A., Bedin, F., Beseme, F., Paranhos-Baccala, G., Komurian-Pradel, F., Mallet, F., Tuke, P. W., Voisset, C., Blond, J. L., Lalande, B., Seigneurin, J. M., Mandrand, B., & Sclerosis, T. C. R. G. O. M. (1997). Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.14.7583
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