The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase
Open accessAbstract
The major mutagenic base lesion in DNA caused by exposure to reactive oxygen species is 8-hydroxyguanine (8-oxo-7,8-dihydroguanine). In bacteria and Saccharomyces cerevisiae , this damaged base is excised by a DNA glycosylase with an associated lyase activity for chain cleavage. We have cloned, sequenced, and expressed a human cDNA with partial sequence homology to the relevant yeast gene. The encoded 47-kDa human enzyme releases free 8-hydroxyguanine from oxidized DNA and introduces a chain break in a double-stranded oligonucleotide specifically at an 8-hydroxyguanine residue base paired with cytosine. Expression of the human protein in a DNA repair-deficient E. coli mutM mutY strain partly suppresses its spontaneous mutator phenotype. The gene encoding the human enzyme maps to chromosome 3p25. These results show that human cells have an enzyme that can initiate base excision repair at mutagenic DNA lesions caused by active oxygen.
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Citations
Cites
Instability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679
Self-citation
Cited by
Oxidative DNA damage and disease: induction, repair and significance
Evans, M. D., Dizdaroglu, M., & Cooke, M. S. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.11.001 · Cited by 1,372
Krokan, H. E., & Bjoras, M. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012583 · Cited by 1,322
Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA
Bruner, S. D., Norman, D. P. G., & Verdine, G. L. (2000) · Nature · doi:10.1038/35002510 · Cited by 972
Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
Klungland, A., Rosewell, I., Hollenbach, S., Larsen, E., Daly, G., Epe, B., Seeberg, E., Lindahl, T., & Barnes, D. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13300 · Cited by 807
Self-citationDNA Oxidation as Triggered by H3K9me2 Demethylation Drives Estrogen-Induced Gene Expression
Perillo, B., Ombra, M. N., Bertoni, A., Cuozzo, C., Sacchetti, S., Sasso, A., Chiariotti, L., Malorni, A., Abbondanza, C., & Avvedimento, E. V. (2008) · Science · doi:10.1126/science.1147674 · Cited by 527
Metadata
- Authors
- Roldán-Arjona, T., Wei, Y.-F., Carter, K. C., Klungland, A., Anselmino, C., Wang, R.-P., Augustus, M., & Lindahl, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-07-22
- Volume
- 94
- Issue
- 15
- Pages
- 8016-8020
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2085877659
- Cited by
- 354
- References
- 1
- FWCI
- 11.36
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Roldán-Arjona, T., Wei, Y.-F., Carter, K. C., Klungland, A., Anselmino, C., Wang, R.-P., Augustus, M., & Lindahl, T. (1997). Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.15.8016
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