Base Excision Repair

DNA Repair and Mutagenesis

Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683 · see citing works

Instability and decay of the primary structure of DNA

Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679 · see citing works

Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting

Gu, H., Marth, J. D., Orban, P. C., Mossmann, H., & Rajewsky, K. (1994) · Science · doi:10.1126/science.8016642 · Cited by 1,397 · see citing works

Base-excision repair of oxidative DNA damage

David, S. S., O'Shea, V. L., & Kundu, S. (2007) · Nature · doi:10.1038/nature05978 · Cited by 1,238 · see citing works

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

Gibson, B. A., & Kraus, W. L. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3376 · Cited by 1,226 · see citing works

Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells

Muramatsu, M., Sankaranand, V. S., Anant, S., Sugai, M., Kinoshita, K., Davidson, N. O., & Honjo, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18470 · Cited by 1,165 · see citing works

Molecular Mechanisms of Antibody Somatic Hypermutation

Noia, J. M. D., & Neuberger, M. S. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.061705.090740 · Cited by 1,108 · see citing works

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

Murcia, J. M., Niedergang, C., Trucco, C., Ricoul, M., Dutrillaux, B., Mark, M. P., Oliver, F. J., Masson, M., Dierich, A., LeMeur, M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7303 · Cited by 1,058 · see citing works

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.Preprint

Wang, Z. Q., Auer, B., Stingl, L., Berghammer, H., Haidacher, D., Schweiger, M. R., & Wagner, E. F. (1995) · Genes & Development · doi:10.1101/gad.9.5.509 · Cited by 774 · see citing works

DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination

Mol, C. D., Izumi, T., MITRA, S. P., & Tainer, J. A. (2000) · Nature · doi:10.1038/35000249 · Cited by 756 · see citing works

Immunoglobulin Isotype Switching Is Inhibited and Somatic Hypermutation Perturbed in UNG-Deficient Mice

Rada, C. A., Williams, G. T., Nilsen, H. L., Barnes, D. E., Lindahl, T. L., & Neuberger, M. S. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01215-0 · Cited by 712 · see citing works

Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells

Hegde, M. L., Hazra, T. K., & MITRA, S. P. (2008) · Cell Research · doi:10.1038/cr.2008.8 · Cited by 663 · see citing works

Free radicals and aging

Barja, G. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.07.005 · Cited by 653 · see citing works

DNA Repair in Mammalian Cells

Robertson, A. B., Klungland, A., Rognes, T., & Leiros, I. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-8736-z · Cited by 652 · see citing works

Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

Imai, K., Slupphaug, G., Lee, W., Revy, P., Nonoyama, S., Catalan, N., Yel, L., Forveille, M., Kavli, B., Krokan, H. E., et al. (2003) · Nature Immunology · doi:10.1038/ni974 · Cited by 633 · see citing works

An N -Glycosidase from Escherichia coli That Releases Free Uracil from DNA Containing Deaminated Cytosine Residues

Lindahl, T. L. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.9.3649 · Cited by 605 · see citing works

Cloning and characterization of hOGG1 , a human homolog of the OGG1 gene of Saccharomyces cerevisiae

Radicella, J. P., Dhérin, C., Desmaze, C., Fox, M. S., & Boiteux, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8010 · Cited by 595 · see citing works

A nucleotide-flipping mechanism from the structure of human uracil–DNA glycosylase bound to DNA

Slupphaug, G., Mol, C. D., Kavli, B., Arvai, A. S., Krokan, H. E., & Tainer, J. A. (1996) · Nature · doi:10.1038/384087a0 · Cited by 581 · see citing works

DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice

Meira, L. B., Bugni, J. M., Green, S. L., Lee, C., Pang, B., Borenshtein, D., Rickman, B. H., Rogers, A. B., Moroski-Erkul, C. A., McFaline‐Figueroa, J. L., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35073 · Cited by 548 · see citing works

The Many Functions of APE1/Ref-1: Not Only a DNA Repair Enzyme

Tell, G., Quadrifoglio, F., Tiribelli, C., & Kelley, M. R. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2194 · Cited by 515 · see citing works

Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

Hazra, T. K., Izumi, T., Boldogh, I. R., Imhoff, B. R., Kow, Y. W., Jaruga, P., Dizdaroğlu, M., & MITRA, S. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062053799 · Cited by 497 · see citing works

Uracil in DNA – occurrence, consequences and repair

Krokan, H. E., Drabløs, F., & Slupphaug, G. (2002) · Oncogene · doi:10.1038/sj.onc.1205996 · Cited by 492 · see citing works

The diverse roles and clinical relevance of PARPs in DNA damage repair: Current state of the art

Vos, M. D., Schreiber, V., & Dantzer, F. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.03.018 · Cited by 491 · see citing works

Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase

Rosenquist, T. A., Zharkov, D. O., & Grollman, A. P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7429 · Cited by 485 · see citing works

Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation

Hashimoto, H., Liu, Y., Upadhyay, A. K., Chang, Y., Howerton, S. B., Vertino, P. M., Zhang, X., & Cheng, X. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks155 · Cited by 478 · see citing works

A unified view of base excision repair: Lesion-dependent protein complexes regulated by post-translational modification

Almeida, K. H., & Sobol, R. W. (2007) · DNA Repair · doi:10.1016/j.dnarep.2007.01.009 · Cited by 437 · see citing works

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

Kovtun, I. V., Liu, Y., Bjoras, M., Klungland, A., Wilson, S. H., & McMurray, C. T. (2007) · Nature · doi:10.1038/nature05778 · Cited by 433 · see citing works

DNA glycosylases: In DNA repair and beyond

Jacobs, A. L., & Schär, P. (2012) · Chromosoma · doi:10.1007/s00412-011-0347-4 · Cited by 407 · see citing works

Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C->T:A mutations

Jones, S. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.23.2961 · Cited by 401 · see citing works

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

Cortázar, D., Kunz, C., Selfridge, J., Lettieri, T., Saito, Y., MacDougall, E., Wirz, A., Schuermann, D., Jacobs, A. L., Siegrist, F., et al. (2011) · Nature · doi:10.1038/nature09672 · Cited by 389 · see citing works

Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase

Roldán‐Arjona, T., Wei, Y.-F., Carter, K. C., Klungland, A., Anselmino, C., Wang, R., Augustus, M., & Lindahl, T. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8016 · Cited by 354 · see citing works

Crystal structure and mutational analysis of human uracil-DNA glycosylase: Structural basis for specificity and catalysis

Mol, C. D., Arvai, A. S., Slupphaug, G., Kavli, B., Alseth, I., Krokan, H. E., & Tainer, J. A. (1995) · Cell · doi:10.1016/0092-8674(95)90290-2 · Cited by 351 · see citing works

Opposite base‐dependent reactions of a human base excision repair enzyme on DNA containing 7,8‐dihydro‐8‐oxoguanine and abasic sites

Bjørås, M., Luna, L., Johnsen, B., Hoff, E., Haug, T., Rognes, T., & Seeberg, E. C. (1997) · The EMBO Journal · doi:10.1093/emboj/16.20.6314 · Cited by 351 · see citing works

DNA repair deficiency in neurodegeneration

Jeppesen, D. K., Bohr, V. A., & Stevnsner, T. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.04.013 · Cited by 349 · see citing works

Repair of Oxidized Bases in DNA Bubble Structures by Human DNA Glycosylases NEIL1 and NEIL2

Hong, D., MITRA, S. P., & Hazra, T. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308658200 · Cited by 344 · see citing works

Post‐replicative base excision repair in replication foci

Otterlei, M., Warbrick, E., Nagelhus, T. A., Haug, T., Slupphaug, G., Akbari, M., Aas, P. A., Steinsbekk, K., Bakke, O., & Krokan, H. E. (1999) · The EMBO Journal · doi:10.1093/emboj/18.13.3834 · Cited by 340 · see citing works

Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue.

Aburatani, H., Hippo, Y., Ishida, T., Takashima, R., Matsuba, C., Kodama, T., Takao, M., Yasui, A., Yamamoto, K., & Asano, M. (1997) · PubMed · Cited by 333 · see citing works

Base excision repair and cancer

Wallace, S. S., Murphy, D. L., & Sweasy, J. B. (2012) · Cancer Letters · doi:10.1016/j.canlet.2011.12.038 · Cited by 329 · see citing works

A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII

Bandaru, V. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00036-8 · Cited by 329 · see citing works

Identification and Characterization of a Novel Human DNA Glycosylase for Repair of Cytosine-derived Lesions

Hazra, T. K., Kow, Y. W., Hatahet, Z., Imhoff, B. R., Boldogh, I. R., Mokkapati, S. K., MITRA, S. P., & Izumi, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200355200 · Cited by 325 · see citing works

A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer

Lu, R., Nash, H. M., & Verdine, G. L. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00187-4 · Cited by 323 · see citing works

Uracil-DNA Glycosylase (UNG)-Deficient Mice Reveal a Primary Role of the Enzyme during DNA Replication

Nilsen, H. L., Rosewell, I. R., Robins, P., Skjelbred, C. F., Andersen, S. B., Slupphaug, G., Daly, G., Krokan, H. E., Lindahl, T. L., & Barnes, D. E. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80271-3 · Cited by 320 · see citing works

Base damage and single-strand break repair: Mechanisms and functional significance of short- and long-patch repair subpathways

FORTINI, P., & DOGLIOTTI, E. (2007) · DNA Repair · doi:10.1016/j.dnarep.2006.10.008 · Cited by 318 · see citing works

Poly(ADP-Ribose) Polymerase 1 Accelerates Single-Strand Break Repair in Concert with Poly(ADP-Ribose) Glycohydrolase

Fisher, A. E. O., Hochegger, H., Takeda, S., & Caldecott, K. W. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02248-06 · Cited by 315 · see citing works

Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene

Nilsen, H. L., Otterlei, M., Haug, T., Steinsbekk, K. S., Hernes, T. A. N., Skorpen, F., & Krokan, H. E. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.4.750 · Cited by 314 · see citing works

Structure and Mechanism of DNA Polymerase β

Beard, W. A., & Wilson, S. H. (2006) · Chemical Reviews · doi:10.1021/cr0404904 · Cited by 299 · see citing works

Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate

Ström, C. E., Johansson, F., Uhlén, M., Szigyarto, C. A., Erixon, K., & Helleday, T. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1241 · Cited by 297 · see citing works

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

Tsutakawa, S. E., Classen, S., Chapados, B. R., Arvai, A. S., Finger, L. D., Guenther, G., Tomlinson, C. G., Thompson, P., Sarker, A. H., Shen, B., et al. (2011) · Cell · doi:10.1016/j.cell.2011.03.004 · Cited by 293 · see citing works

Deficiencies in Mouse <b> <i>Myh</i> </b> and <b> <i>Ogg1</i> </b> Result in Tumor Predisposition and G to T Mutations in Codon 12 of the <b> <i>K-Ras</i> </b> Oncogene in Lung Tumors

Xie, Y., Yang, H., Cunanan, C., Okamoto, K., Shibata, D., Pan, J., Barnes, D. E., Lindahl, T., McIlhatton, M., Fishel, R., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3834 · Cited by 291 · see citing works

Crystal Structure of a Human Alkylbase-DNA Repair Enzyme Complexed to DNA

Lau, A. Y., Schärer, O. D., Samson, L. D., Verdine, G. L., & Ellenberger, T. (1998) · Cell · doi:10.1016/s0092-8674(00)81755-9 · Cited by 290 · see citing works

Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA

Morland, I. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf618 · Cited by 284 · see citing works

Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III

Aspinwall, R., Rothwell, D. G., Roldán‐Arjona, T., Anselmino, C., Ward, C. J., Cheadle, J. P., Sampson, J. R., Lindahl, T. L., Harris, P. C., & Hickson, I. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.1.109 · Cited by 273 · see citing works

Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA

Yang, C., Yi, C., Duguid, E. M., Sullivan, C. T., Jian, X., Rice, P. A., & He, C. (2008) · Nature · doi:10.1038/nature06889 · Cited by 262 · see citing works

Toward a Detailed Understanding of Base Excision Repair Enzymes: Transition State and Mechanistic Analyses of N-Glycoside Hydrolysis and N-Glycoside Transfer

Berti, P. J., & McCann, J. A. B. (2006) · Chemical Reviews · doi:10.1021/cr040461t · Cited by 257 · see citing works

The Type of DNA Glycosylase Determines the Base Excision Repair Pathway in Mammalian Cells

Fortini, P., Parlanti, E., Sidorkina, O. M., Laval, J., & Eugenia Dogliotti, Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.15230 · Cited by 249 · see citing works

The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase

Vartanian, V. L., Lowell, B., Minko, I. G., Wood, T. G., Ceci, J. D., George, S., Ballinger, S. W., Corless, C. L., McCullough, A. K., & Lloyd, R. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507444103 · Cited by 248 · see citing works

Structural Basis for the Excision Repair of Alkylation-Damaged DNA

Labahn, J., Schärer, O. D., Long, A., Ezaz‐Nikpay, K., Verdine, G. L., & Ellenberger, T. (1996) · Cell · doi:10.1016/s0092-8674(00)80103-8 · Cited by 245 · see citing works

Is There a Link Between DNA Polymerase Beta and Cancer?

Starcevic, D., Dalal, S., & Sweasy, J. B. (2004) · Cell Cycle · doi:10.4161/cc.3.8.1062 · Cited by 240 · see citing works

Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair

Simsek, D., Furda, A. M., Gao, Y., Artus, J., Brunet, E., Hadjantonakis, A., Houten, B. V., Shuman, S., McKinnon, P. J., & Jasin, M. (2011) · Nature · doi:10.1038/nature09794 · Cited by 227 · see citing works

Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG

Lau, A. Y., Wyatt, M. D., Glassner, B. J., Samson, L. D., & Ellenberger, T. E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.25.13573 · Cited by 227 · see citing works

A Back-up Glycosylase in Nth1 Knock-out Mice Is a Functional Nei (Endonuclease VIII) Homologue

Takao, M., Kanno, S., Kobayashi, K., Zhang, Q.-M., Yonei, S., van der Horst, G. T. J., & Yasui, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206884200 · Cited by 226 · see citing works

DNA bending and a flip‐out mechanism for base excision by the helix–hairpin–helix DNA glycosylase, Escherichia coli AlkA

Hollis, T., Ichikawa, Y., & Ellenberger, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.4.758 · Cited by 222 · see citing works

Human DNA2 Is a Mitochondrial Nuclease/Helicase for Efficient Processing of DNA Replication and Repair Intermediates

Zheng, L., Zhou, M., Guo, Z., Lu, H., Qian, L., Dai, H., Qiu, J., Yakubovskaya, E., Bogenhagen, D. F., Demple, B., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.09.024 · Cited by 222 · see citing works

The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability

Riccio, A., Aaltonen, L. A., Godwin, A. K., Loukola, A., Percesepe, A., Salovaara, R., Masciullo, V., Genuardi, M., Paravatou‐Petsotas, M., Bassi, D., et al. (1999) · Nature Genetics · doi:10.1038/15443 · Cited by 209 · see citing works

Removal of Oxidative DNA Damage via FEN1-Dependent Long-Patch Base Excision Repair in Human Cell Mitochondria

Liu, P., Qian, L., Sung, J., de Souza-Pinto, N. C., Zheng, L., Bogenhagen, D. F., Bohr, V. A., Wilson, D. M., Shen, B., & Demple, B. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00457-08 · Cited by 209 · see citing works

DNA base damage recognition and removal: New twists and grooves

Huffman, J. L., Sundheim, O., & Tainer, J. A. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.03.012 · Cited by 208 · see citing works

AID and Somatic Hypermutation

Maul, R. W., & Gearhart, P. J. (2010) · Advances in immunology · doi:10.1016/s0065-2776(10)05006-6 · Cited by 206 · see citing works

The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo

Liu, M., Bandaru, V., Bond, J. P., Jaruga, P., Zhao, X., Christov, P. P., Burrows, C. J., Rizzo, C. J., Dizdaroğlu, M., & Wallace, S. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908307107 · Cited by 203 · see citing works

The enigmatic thymine DNA glycosylase

Cortázar, D., Kunz, C., Saito, Y., Steinacher, R., & Schär, P. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.10.013 · Cited by 199 · see citing works

DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair

Gao, Y., Katyal, S., Lee, Y., Zhao, J., Rehg, J. E., Russell, H. R., & McKinnon, P. J. (2011) · Nature · doi:10.1038/nature09773 · Cited by 193 · see citing works

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination

Guikema, J. E. J., Linehan, E. K., Tsuchimoto, D., Nakabeppu, Y., Strauss, P. R., Stavnezer, J., & Schrader, C. E. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071289 · Cited by 191 · see citing works

Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress

Bauer, M., Goldstein, M., Christmann, M., Becker, H., Heylmann, D., & Kaina, B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111919109 · Cited by 187 · see citing works

Uracil in DNA—General mutagen, but normal intermediate in acquired immunity

Kavli, B., Otterlei, M., Slupphaug, G., & Krokan, H. E. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.10.014 · Cited by 178 · see citing works

Detection of Damaged DNA Bases by DNA Glycosylase Enzymes

Friedman, J. I., & Stivers, J. T. (2010) · Biochemistry · doi:10.1021/bi100593a · Cited by 175 · see citing works

DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy

Tubbs, J. L., Pegg, A. E., & Tainer, J. A. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.03.011 · Cited by 175 · see citing works

Recognition of the oxidized lesions spiroiminodihydantoin and guanidinohydantoin in DNA by the mammalian base excision repair glycosylases NEIL1 and NEIL2

Hailer, M. K., Slade, P. G., Martin, B. D., Rosenquist, T. A., & Sugden, K. D. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.07.006 · Cited by 167 · see citing works

HMGB1 Is a Cofactor in Mammalian Base Excision Repair

Prasad, R., Liu, Y., Deterding, L. J., Poltoratsky, V. P., Kedar, P. S., Horton, J. K., Kanno, S., Asagoshi, K., Hou, E. W., Khodyreva, S. N., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.029 · Cited by 163 · see citing works

Accumulation of the Oxidative Base Lesion 8-Hydroxyguanine in DNA of Tumor-Prone Mice Defective in Both the Myh and Ogg1 DNA Glycosylases

Russo, M. T., Luca, G. D., Degan, P., Parlanti, E., Eugenia Dogliotti, Y., Barnes, D. E., Lindahl, T. L., Yang, H., Miller, J. H., & Bignami, M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0355 · Cited by 160 · see citing works

DNA base repair – recognition and initiation of catalysis

Dalhus, B., Laerdahl, J. K., Backe, P. H., & Bjørås, M. (2009) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2009.00188.x · Cited by 159 · see citing works

DNA repair in mammalian mitochondria: Much more than we thought?

Liu, P., & Demple, B. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20576 · Cited by 159 · see citing works

DNA Deamination in Immunity: AID in the Context of Its APOBEC Relatives

Conticello, S. G., Langlois, M., Yang, Z., & Neuberger, M. S. (2007) · Advances in immunology · doi:10.1016/s0065-2776(06)94002-4 · Cited by 158 · see citing works

Long Patch Base Excision Repair in Mammalian Mitochondrial Genomes

Szczęsny, B., Tann, A. W., Longley, M. J., Copeland, W. C., & MITRA, S. P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803491200 · Cited by 158 · see citing works

Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage Version 7

Friedberg, E. C., & Meira, L. B. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.09.009 · Cited by 155 · see citing works

V(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining

Soulas-Sprauel, P., Rivera-Muñoz, P., Malivert, L., Guyader, G. L., Abramowski, V., Revy, P., & de Villartay, J. (2007) · Oncogene · doi:10.1038/sj.onc.1210875 · Cited by 152 · see citing works

Activation-Induced Cytidine Deaminase-Dependent DNA Breaks in Class Switch Recombination Occur during G1 Phase of the Cell Cycle and Depend upon Mismatch Repair

Schrader, C. E., Guikema, J. E. J., Linehan, E. K., Selsing, E., & Stavnezer, J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.9.6064 · Cited by 150 · see citing works

Crystal structure of a repair enzyme of oxidatively damaged DNA, MutM (Fpg), from an extreme thermophile, Thermus thermophilus HB8

Sugahara, M., Mikawa, T., Kumasaka, T., Yamamoto, M., Kato, R., Fukuyama, K., Inoue, Y., & Kuramitsu, S. (2000) · The EMBO Journal · doi:10.1093/emboj/19.15.3857 · Cited by 147 · see citing works

Cell cycle‐specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA

Hagen, L., Kavli, B., de Sousa, M. M. L., Torseth, K., Liabakk, N., Sundheim, O., Peña-Dı́az, J., Otterlei, M., Hørning, O. B., Jensen, O. N., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601958 · Cited by 139 · see citing works

Dynamic opening of DNA during the enzymatic search for a damaged base

Cao, C., Jiang, Y. L., Stivers, J. T., et al. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb864 · Cited by 134 · see citing works

DNA-uracil and human pathology

de Sousa, M. M. L., Krokan, H. E., & Slupphaug, G. (2007) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2007.04.006 · Cited by 132 · see citing works

Complex regulation and function of activation-induced cytidine deaminase

Stavnezer, J. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.03.003 · Cited by 130 · see citing works

Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase

Endres, M., Biniszkiewicz, D., Sobol, R. W., Harms, C., Ahmadi, M., Lipski, A., Katchanov, J., Mergenthaler, P., Dirnagl, U., Wilson, S. H., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420926 · Cited by 128 · see citing works

Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis

Akbari, M., Visnes, T., Krokan, H. E., & Otterlei, M. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.01.002 · Cited by 127 · see citing works

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation

Pettersen, H. S., Visnes, T., Vågbø, C. B., Svaasand, E. K., Doseth, B., Slupphaug, G., Kavli, B., & Krokan, H. E. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr563 · Cited by 127 · see citing works

HMGB1: Roles in base excision repair and related function

Liu, Y., Prasad, R., & Wilson, S. H. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.11.008 · Cited by 126 · see citing works

Uracil–DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms

Pettersen, H. S., Sundheim, O., Gilljam, K. M., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm372 · Cited by 125 · see citing works

Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA

Chan, M. K., Ocampo-Hafalla, M. T., Vartanian, V. L., Jaruga, P., Kırkalı, G., Koenig, K. L., Brown, S. M., Lloyd, R. S., Dizdaroğlu, M., & Teebor, G. W. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.03.001 · Cited by 124 · see citing works

Evidence that OGG1 Glycosylase Protects Neurons against Oxidative DNA Damage and Cell Death under Ischemic Conditions

Liu, D., Croteau, D. L., de Souza-Pinto, N. C., PITTA, M. G. R., Tian, J., Wu, C. W., Jiang, H., Mustafa, K., Keijzers, G., Bohr, V. A., et al. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.147 · Cited by 123 · see citing works

Terminally differentiated muscle cells are defective in base excision DNA repair and hypersensitive to oxygen injury

Narciso, L., Fortini, P., Pajalunga, D., Franchitto, A., Liu, P., Degan, P., Fréchet, M., Demple, B., Crescenzi, M., & Eugenia Dogliotti, Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701743104 · Cited by 117 · see citing works

ATP-Dependent Chromatin Remodeling Is Required for Base Excision Repair in Conventional but Not in Variant H2A.Bbd Nucleosomes

Menoni, H., Gasparutto, D., Hamiche, A., Cadet, J., Dimitrov, S. I., Bouvet, P., & Angelov, D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00376-07 · Cited by 114 · see citing works

5-Fluorouracil Is Efficiently Removed From DNA by the Base Excision and Mismatch Repair Systems

Fischer, F., Baerenfaller, K., & Jiricny, J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.09.003 · Cited by 113 · see citing works

Rules of engagement for base excision repair in chromatin

Odell, I. D., Wallace, S. S., & Pederson, D. S. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24134 · Cited by 113 · see citing works

Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase

Endres, M., Biniszkiewicz, D., Sobol, R. W., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20926 · Cited by 111 · see citing works

Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts

Andersen, S. B. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh347 · Cited by 111 · see citing works

DNA Polymerase λ Protects Mouse Fibroblasts against Oxidative DNA Damage and Is Recruited to Sites of DNA Damage/Repair

Braithwaite, E. K., Kedar, P. S., Lan, L., Polosina, Y. Y., Asagoshi, K., Poltoratsky, V. P., Horton, J. K., Miller, H., Teebor, G. W., Yasui, A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500256200 · Cited by 109 · see citing works

Physical and Functional Interaction between Human Oxidized Base-specific DNA Glycosylase NEIL1 and Flap Endonuclease 1

Hegde, M. L., Theriot, C. A., Das, A., Hegde, P. M., Guo, Z., Gary, R. K., Hazra, T. K., Shen, B., & MITRA, S. P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802712200 · Cited by 107 · see citing works

Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks

Woodhouse, B. C., Dianova, I. I., Parsons, J. L., & Dianov, G. L. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.017 · Cited by 107 · see citing works

Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung−/−Msh2−/− mice

Kemmerich, K., Dingler, F. A., Rada, C. A., & Neuberger, M. S. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks259 · Cited by 107 · see citing works

DNA polymerase beta mutations in human colorectal cancer.

Wang, L., Patel, U. A., Ghosh, L., et al. (1992) · PubMed · Cited by 106 · see citing works

The Escherichia coli 3-Methyladenine DNA Glycosylase AlkA Has a Remarkably Versatile Active Site

O’Brien, P., & Ellenberger, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403860200 · Cited by 106 · see citing works

Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation

Hashimoto, H., Zhang, X., & Cheng, X. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks628 · Cited by 105 · see citing works

An Evolutionary Analysis of the Helix-Hairpin-Helix Superfamily of DNA Repair Glycosylases

Denver, D. R. (2003) · Molecular Biology and Evolution · doi:10.1093/molbev/msg177 · Cited by 103 · see citing works

Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells

Akbari, M. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh872 · Cited by 102 · see citing works

Origin of Endogenous DNA Abasic Sites in Saccharomyces cerevisiae

Guillet, M., & Boiteux, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.8386-8394.2003 · Cited by 98 · see citing works

Poly(ADP‐ribose) polymerase‐1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts

Parsons, J. L., Dianova, I. I., Allinson, S. L., & Dianov, G. L. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.04628.x · Cited by 96 · see citing works

The E295K DNA Polymerase Beta Gastric Cancer-Associated Variant Interferes with Base Excision Repair and Induces Cellular Transformation

Lang, T., Dalal, S., Chikova, A. K., DiMaio, D., & Sweasy, J. B. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01883-06 · Cited by 96 · see citing works

Cell cycle regulation as a mechanism for functional separation of the apparently redundant uracil DNA glycosylases TDG and UNG2

Hardeland, U., Kunz, C., Focke, F., Szadkowski, M., & Schär, P. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm337 · Cited by 95 · see citing works

Mutation versus Repair: NEIL1 Removal of Hydantoin Lesions in Single-Stranded, Bulge, Bubble, and Duplex DNA Contexts

Zhao, X., Krishnamurthy, N., Burrows, C. J., & David, S. S. (2010) · Biochemistry · doi:10.1021/bi901852q · Cited by 93 · see citing works

Mammalian DNA β-polymerase in base excision repair of alkylation damage

Sobol, R. W., & Wilson, S. H. (2001) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(01)68090-5 · Cited by 92 · see citing works

Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia

Sejersted, Y., Hildrestrand, G. A., Kunke, D., Rolseth, V., Krokeide, S. Z., Neurauter, C. G., Suganthan, R., Atneosen‐Åsegg, M., Fleming, A. M., Saugstad, O. D., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106880108 · Cited by 89 · see citing works

Single-nucleotide patch base excision repair of uracil in DNA by mitochondrial protein extracts#

Stierum, R. H., Dianov, G. L., & Bohr, V. A. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.18.3712 · Cited by 88 · see citing works

DNA Polymerases β and λ Mediate Overlapping and Independent Roles in Base Excision Repair in Mouse Embryonic Fibroblasts

Braithwaite, E. K., Kedar, P. S., Stumpo, D. J., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012229 · Cited by 86 · see citing works

Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1genes in familial colorectal cancer predisposition

Broderick, P., Bagratuni, T., Vijayakrishnan, J., Lubbe, S. J., Chandler, I. P., & Houlston, R. S. (2006) · BMC Cancer · doi:10.1186/1471-2407-6-243 · Cited by 82 · see citing works

Interference of mismatch and base excision repair during the processing of adjacent U/G mispairs may play a key role in somatic hypermutation

Schanz, S., Castor, D., Fischer, F., & Jiricny, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901726106 · Cited by 81 · see citing works

Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice

Canugovi, C., Yoon, J. S., Feldman, N. H., Croteau, D. L., Mattson, M. P., & Bohr, V. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1204156109 · Cited by 81 · see citing works

Keynote: Past, present, and future aspects of base excision repair

Lindahl, T. (2001) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(01)68084-x · Cited by 80 · see citing works

Uracil in DNA: Consequences for carcinogenesis and chemotherapy

Berger, S. H., Pittman, D. L., & Wyatt, M. D. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.05.019 · Cited by 79 · see citing works

Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas

Jones, S., Lambert, S., Williams, G. T., Best, J. M., Sampson, J. R., & Cheadle, J. P. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601747 · Cited by 77 · see citing works

DNA repair is indispensable for survival after acute inflammation

Calvo, J. A., Meira, L. B., Lee, C. I., Moroski-Erkul, C. A., Abolhassani, N., Taghizadeh, K., Eichinger, L. W., Muthupalani, S., Nordstrand, L. M., Klungland, A., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63338 · Cited by 77 · see citing works

Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations

Radom, C. T., Banerjee, A., & Verdine, G. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608989200 · Cited by 75 · see citing works

Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice

Møllersen, L., Rowe, A. D., Illuzzi, J. L., Hildrestrand, G. A., Gerhold, K. J., Tveterås, L., Bjølgerud, A., Wilson, D. M., Bjørås, M., & Klungland, A. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds337 · Cited by 74 · see citing works

NEIL1 excises 3' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1

Parsons, J. L., Zharkov, D. O., & Dianov, G. L. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki816 · Cited by 74 · see citing works

Evidence that MutY is a monofunctional glycosylase capable of forming a covalent Schiff base intermediate with substrate DNA

Williams, S. D., & David, S. S. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.22.5123 · Cited by 72 · see citing works

Widespread distribution of DNA glycosylases removing oxidative DNA lesions in human and rodent brains

Rolseth, V., Rundén‐Pran, E., Luna, L., McMurray, C. T., Bjørås, M., & Ottersen, O. P. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.06.007 · Cited by 71 · see citing works

Extrahelical Damaged Base Recognition by DNA Glycosylase Enzymes

Stivers, J. T. (2007) · Chemistry - A European Journal · doi:10.1002/chem.200701501 · Cited by 70 · see citing works

Functions of disordered regions in mammalian early base excision repair proteins

Hegde, M. L., Hazra, T. K., & MITRA, S. P. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0485-5 · Cited by 69 · see citing works

XRCC1 coordinates disparate responses and multiprotein repair complexes depending on the nature and context of the DNA damage

Hanssen‐Bauer, A., Solvang‐Garten, K., Sundheim, O., Peña-Dı́az, J., Andersen, S. B., Slupphaug, G., Krokan, H. E., Wilson, D. M., Akbari, M., & Otterlei, M. (2011) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20663 · Cited by 68 · see citing works

A Role for Yeast and Human Translesion Synthesis DNA Polymerases in Promoting Replication through 3-Methyl Adenine

Johnson, R. E., Yu, S., Prakash, S., & Prakash, L. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01079-07 · Cited by 67 · see citing works

Activities and Mechanism of DNA Polymerase β

Beard, W. A., Prasad, R., & Wilson, S. H. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)08007-4 · Cited by 64 · see citing works

Sibling rivalry: competition between Pol X family members in V(D)J recombination and general double strand break repair

McElhinny, S. A. N., & Ramsden, D. A. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00160.x · Cited by 64 · see citing works

A new protein superfamily includes two novel 3‐methyladenine DNA glycosylases from Bacillus cereus, AlkC and AlkD

Alseth, I., Rognes, T., Lindbäck, T., Solberg, I. C., Robertsen, K., Kristiansen, K. I., Mainieri, D., Lillehagen, L., Kolstø, A., & Bjørås, M. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05044.x · Cited by 62 · see citing works

Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency

HORTON, J., & Wilson, S. H. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.10.016 · Cited by 61 · see citing works

Different structural states in oligonucleosomes are required for early versus late steps of base excision repair

Nakanishi, S., Prasad, R., Wilson, S. H., & Smerdon, M. J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm436 · Cited by 59 · see citing works

3-methyladenine DNA glycosylase I is an unexpected helix-hairpin-helix superfamily member

Drohat, A. C., Kwon, K., Krosky, D. J., & Stivers, J. T. (2002) · Nature Structural Biology · doi:10.1038/nsb829 · Cited by 59 · see citing works

Uracil DNA Glycosylase: Insights from a Master Catalyst

Stivers, J. T., & Drohat, A. C. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2605 · Cited by 59 · see citing works

Crystal structures of 3‐methyladenine DNA glycosylase MagIII and the recognition of alkylated bases

Eichman, B. F., O’Rourke, E. J., Radicella, J. P., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg505 · Cited by 57 · see citing works

Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress

Akbari, M., Otterlei, M., Peña-Dı́az, J., & Krokan, H. E. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.10.010 · Cited by 57 · see citing works

Evidence for the Involvement of DNA Repair Enzyme NEIL1 in Nucleotide Excision Repair of (5′R)- and (5′S)-8,5′-Cyclo-2′-deoxyadenosines

Jaruga, P., Xiao, Y., Vartanian, V. L., Lloyd, R. S., & Dizdaroğlu, M. (2010) · Biochemistry · doi:10.1021/bi902161f · Cited by 56 · see citing works

DNA damage recognition and repair by 3‐methyladenine DNA glycosylase I (TAG)

Metz, A. H., Hollis, T., & Eichman, B. F. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601649 · Cited by 56 · see citing works

Exchangeability of Mammalian DNA Ligases between Base Excision Repair Pathways

Sleeth, K. M., Robson, R. L., & Dianov, G. L. (2004) · Biochemistry · doi:10.1021/bi0492612 · Cited by 55 · see citing works

AlkB demethylases flip out in different ways

Sundheim, O., Monsen, V. T., Vågbø, C. B., Slupphaug, G., & Krokan, H. E. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.07.015 · Cited by 54 · see citing works

Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity

Akbari, M., Peña-Dı́az, J., Andersen, S. B., Liabakk, N., Otterlei, M., & Krokan, H. E. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.04.002 · Cited by 53 · see citing works

Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma

Forsbring, M., Vik, E. S., Dalhus, B., Karlsen, T. H., Bergquist, A. M., Schrumpf, E., Bjørås, M., Boberg, K. M., & Alseth, I. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp118 · Cited by 53 · see citing works

Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil

Doseth, B., Ekre, C., Slupphaug, G., et al. (2012) · DNA repair · doi:10.1016/j.dnarep.2012.03.003 · Cited by 51 · see citing works

The rate of base excision repair of uracil is controlled by the initiating glycosylase

Visnes, T., Akbari, M., Hagen, L., et al. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.07.012 · Cited by 48 · see citing works

A New Protein Architecture for Processing Alkylation Damaged DNA: The Crystal Structure of DNA Glycosylase AlkD

Rubinson, E. H., Metz, A. H., O'Quin, J., & Eichman, B. F. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.05.078 · Cited by 47 · see citing works

UNG shapes the specificity of AID-induced somatic hypermutation

Pérez‐Durán, P., Belver, L., de Yébenes, V. G., Delgado, P., Pisano, D. G., & Ramiro, A. R. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112253 · Cited by 47 · see citing works

Colon Cancer-associated DNA Polymerase β Variant Induces Genomic Instability and Cellular Transformation

Nemec, A. A., Donigan, K. A., Murphy, D. L., Jäger, J., & Sweasy, J. B. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.362111 · Cited by 43 · see citing works

Base excision repair and design of small molecule inhibitors of human DNA polymerase β

Wilson, S. H., Beard, W. A., Shock, D. D., Batra, V. K., Cavanaugh, N. A., Prasad, R., Hou, E. W., Liu, Y., Asagoshi, K., Horton, J. K., et al. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0489-1 · Cited by 39 · see citing works

Mismatch and base excision repair proficiency in murine embryonic stem cells

Tichy, E. D., Liang, L., Deng, L., Tischfield, J. A., Schwemberger, S. J., Babcock, G. F., & Stambrook, P. J. (2011) · DNA repair · doi:10.1016/j.dnarep.2011.01.008 · Cited by 38 · see citing works

The role of mammalian NEIL1 protein in the repair of 8‐oxo‐7,8‐dihydroadenine in DNA

Грин, И. Р., Dianov, G. L., & Zharkov, D. O. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.03.009 · Cited by 38 · see citing works

Solution Structure and Base Perturbation Studies Reveal a Novel Mode of Alkylated Base Recognition by 3-Methyladenine DNA Glycosylase I

Cao, C., Kwon, K., Jiang, Y. L., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307500200 · Cited by 37 · see citing works

Controlling somatic hypermutation in immunoglobulin variable and switch regions

Maul, R. W., & Gearhart, P. J. (2010) · Immunologic Research · doi:10.1007/s12026-009-8142-5 · Cited by 35 · see citing works

The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA

Torseth, K., Doseth, B., Hagen, L., et al. (2012) · DNA repair · doi:10.1016/j.dnarep.2012.03.006 · Cited by 35 · see citing works

DNA repair in mammalian mitochondria: much more than we thought? Environ Mol Mutagen

Liu, P., & Demple, B. (2010) · Cited by 35 · see citing works

Structural insight into repair of alkylated DNA by a new superfamily of DNA glycosylases comprising HEAT-like repeats

Dalhus, B., Helle, I. H., Backe, P. H., Alseth, I., Rognes, T., Bjørås, M., & Laerdahl, J. K. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm039 · Cited by 34 · see citing works

Phylogenomic Analysis of the Uracil-DNA Glycosylase Superfamily

Lucas‐Lledó, J. I., Maddamsetti, R., & Lynch, M. F. (2010) · Molecular Biology and Evolution · doi:10.1093/molbev/msq318 · Cited by 31 · see citing works

NEIL1 Is the Major DNA Glycosylase that Processes 5-Hydroxyuracil in the Proximity of a DNA Single-Strand Break

Parsons, J. L., Kavli, B., Slupphaug, G., & Dianov, G. L. (2007) · Biochemistry · doi:10.1021/bi0622569 · Cited by 30 · see citing works

The Bacillus subtilis Counterpart of the Mammalian 3-Methyladenine DNA Glycosylase Has Hypoxanthine and 1,N6-Ethenoadenine as Preferred Substrates

Aamodt, R. M., Falnes, P. Ø., Johansen, R., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314277200 · Cited by 29 · see citing works

Mechanistic details of the DNA recognition by the Dnmt1 DNA methyltransferase

Bashtrykov, P., Ragozin, S., & Jeltsch, A. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.05.026 · Cited by 28 · see citing works

The E288K Colon Tumor Variant of DNA Polymerase β Is a Sequence Specific Mutator

Murphy, D. L., Donigan, K. A., Jäger, J., & Sweasy, J. B. (2012) · Biochemistry · doi:10.1021/bi3003583 · Cited by 22 · see citing works

Kinetic Effect of a Downstream Strand and Its 5′-Terminal Moieties on Single Nucleotide Gap-filling Synthesis Catalyzed by Human DNA Polymerase λ

Duym, W. W., Fiala, K. A., Bhatt, N., & Suo, Z. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607479200 · Cited by 19 · see citing works

Rev1 and Polζ influence toxicity and mutagenicity of Me-lex, a sequence selective N3-adenine methylating agent

Monti, P., Ciribilli, Y., Russo, D., et al. (2008) · DNA repair · doi:10.1016/j.dnarep.2007.11.015 · Cited by 19 · see citing works

Abasic sites linked to dUTP incorporation in DNA are a major cause of spontaneous mutations in absence of base excision repair and Rad17–Mec3–Ddc1 (9–1–1) DNA damage checkpoint clamp in Saccharomyces cerevisiae

Collura, A., van der Kemp, P. A., & Boiteux, S. (2012) · DNA repair · doi:10.1016/j.dnarep.2011.12.004 · Cited by 14 · see citing works

Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair

Schrader, C. E., Guikema, J. E. J., Linehan, E. K., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.1.664-c · Cited by 5 · see citing works

Toward a Detailed Understanding of Base Excision Repair Enzymes: Transition State and Mechanistic Analyses of N‐Glycoside Hydrolysis and N‐Glycoside Transfer

Berti, P. J., & McCann, J. A. B. (2006) · ChemInform · doi:10.1002/chin.200621267 · Cited by 3 · see citing works

Structure and Mechanism of DNA Polymerase β

Beard, W. A., & Wilson, S. H. (2006) · ChemInform · doi:10.1002/chin.200621260 · Cited by 2 · see citing works

Mechanisms of DNA damage, repair, and mutagenesis

Chatterjee, N., & Walker, G. C. (2017) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22087 · Cited by 2,039 · see citing works

Mechanisms and Consequences of Double‐Strand DNA Break Formation in Chromatin

Cannan, W. J., & Pederson, D. S. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25048 · Cited by 499 · see citing works

RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response

Maréchal, A., & Zou, L. (2015) · Cell Research · doi:10.1038/cr.2014.147 · Cited by 465 · see citing works

Base excision repair: A critical player in many games

Wallace, S. S. (2014) · DNA Repair · doi:10.1016/j.dnarep.2014.03.030 · Cited by 401 · see citing works

DNA Damage in Stem Cells

Vitale, I., Manic, G., De Maria, R., Kroemer, G., & Galluzzi, L. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.04.006 · Cited by 361 · see citing works

Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork

Choe, K. N., & Moldovan, G.-L. (2017) · Molecular Cell · doi:10.1016/j.molcel.2016.12.020 · Cited by 325 · see citing works

Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis

Fouquerel, E., Barnes, R. P., Uttam, S., Watkins, S. C., Bruchez, M. P., & Opresko, P. L. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.04.024 · Cited by 275 · see citing works

DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging

Tiwari, V., & Wilson, D. M. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.06.005 · Cited by 244 · see citing works

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

Yan, S., Sorrell, M., & Berman, Z. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1666-4 · Cited by 247 · see citing works

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease

Pao, P.-C., Patnaik, D., Watson, L. A., Gao, F., Pan, L., Wang, J., Adaikkan, C., Penney, J., Cam, H. P., Huang, W.-C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16361-y · Cited by 216 · see citing works

ROS induces NETosis by oxidizing DNA and initiating DNA repair

Azzouz, D., Khan, M. A., & Palaniyar, N. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00491-3 · Cited by 202 · see citing works

Impact of ambient PM2.5 on adverse birth outcome and potential molecular mechanism

Li, Z., Tang, Y., Song, X., Lazar, L., Li, Z., & Zhao, J. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.10.109 · Cited by 193 · see citing works

Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies

Kciuk, M., Marciniak, B., Mojzych, M., & Kontek, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197264 · Cited by 168 · see citing works

The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging‐Related Diseases from Eukaryotic and Prokaryotic Model Organisms

Santos, A. L., Sinha, S., & Lindner, A. B. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1941285 · Cited by 168 · see citing works

Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination

Hwang*, J. K., Alt*, F. W., & Yeap, L.-S. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mdna3-0037-2014 · Cited by 126 · see citing works

Somatic and Germline Mutation Periodicity Follow the Orientation of the DNA Minor Groove around Nucleosomes

Pich, O., Muiños, F., Sabarinathan, R., Reyes-Salazar, I., Gonzalez-Perez, A., & Lopez-Bigas, N. (2018) · Cell · doi:10.1016/j.cell.2018.10.004 · Cited by 123 · see citing works

Integrating the DNA damage and protein stress responses during cancer development and treatment

Gorgoulis, V. G., Pefani, D., Pateras, I. S., & Trougakos, I. P. (2018) · The Journal of Pathology · doi:10.1002/path.5097 · Cited by 108 · see citing works

Placental promoter methylation of DNA repair genes and prenatal exposure to particulate air pollution: an ENVIR ON AGE cohort study

Neven, K. Y., Saenen, N. D., Tarantini, L., Janssen, B. G., Lefebvre, W., Vanpoucke, C., Bollati, V., & Nawrot, T. S. (2018) · The Lancet Planetary Health · doi:10.1016/s2542-5196(18)30049-4 · Cited by 103 · see citing works

Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy?

Yamanaka, K., Chatterjee, N., Hemann, M. T., & Walker, G. C. (2017) · PLOS Genetics · doi:10.1371/journal.pgen.1006842 · Cited by 87 · see citing works

HIV-1 and HIV-2 exhibit divergent interactions with HLTF and UNG2 DNA repair proteins

Hrecka, K., Hao, C., Shun, M.-C., Kaur, S., Swanson, S. K., Florens, L., Washburn, M. P., & Skowronski, J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605023113 · Cited by 80 · see citing works

Sequencing abasic sites in DNA at single-nucleotide resolution

Liu, Z. J., Martínez Cuesta, S., van Delft, P., & Balasubramanian, S. (2019) · Nature Chemistry · doi:10.1038/s41557-019-0279-9 · Cited by 83 · see citing works

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

Galanos, P., Pappas, G., Polyzos, A., Kotsinas, A., Svolaki, I., Giakoumakis, N. N., Glytsou, C., Pateras, I. S., Swain, U., Souliotis, V. L., et al. (2018) · Genome Biology · doi:10.1186/s13059-018-1401-9 · Cited by 67 · see citing works

Crosstalk between G-quadruplex and ROS

Wu, S., Jiang, L., Lei, L., Fu, C., Huang, J., Hu, Y., Dong, Y., Chen, J., & Zeng, Q. (2023) · Cell Death &amp; Disease · doi:10.1038/s41419-023-05562-0 · Cited by 69 · see citing works

Abasic and oxidized ribonucleotides embedded in DNA are processed by human APE1 and not by RNase H2

Malfatti, M. C., Balachander, S., Antoniali, G., Koh, K. D., Saint-Pierre, C., Gasparutto, D., Chon, H., Crouch, R. J., Storici, F., & Tell, G. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx723 · Cited by 59 · see citing works

DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells

Oh, S., Harvey, A., Zimbric, J., Wang, Y., Nguyen, T., Jackson, P. J., & Hendrickson, E. A. (2014) · DNA Repair · doi:10.1016/j.dnarep.2014.04.015 · Cited by 58 · see citing works

Non-bulky Lesions in Human DNA: The Ways of Formation, Repair, and Replication

Ignatov, А. V., Bondarenko, K. A., & Makarova, A. V. (2017) · Acta Naturae · doi:10.32607/20758251-2017-9-3-12-26 · Cited by 31 · see citing works

Nucleosomes regulate base excision repair in chromatin

Meas, R., Wyrick, J. J., & Smerdon, M. J. (2019) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2017.10.002 · Cited by 28 · see citing works

Breast cancer: miRNAs monitoring chemoresistance and systemic therapy

Singh, S., Saini, H., Sharma, A., Gupta, S., Huddar, V. G., & Tripathi, R. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1155254 · Cited by 25 · see citing works

Transcription Blockage by DNA Damage in Nucleotide Excision Repair-Related Neurological Dysfunctions

Kajitani, G. S., Nascimento, L. L. D. S., Neves, M. R. D. C., Leandro, G. D. S., Garcia, C. C. M., & Menck, C. F. M. (2021) · Seminars in Cell &amp; Developmental Biology · doi:10.1016/j.semcdb.2020.10.009 · Cited by 22 · see citing works

Single-cell parallel analysis of DNA damage and transcriptome reveals selective genome vulnerability

Bai, D., Cao, Z., Attada, N., Song, J., & Zhu, C. (2025) · Nature Methods · doi:10.1038/s41592-025-02632-3 · Cited by 16 · see citing works

Architects meets Repairers: the interplay between homeobox genes and DNA repair

Feltes, B. C. (2019) · DNA Repair · doi:10.1016/j.dnarep.2018.10.007 · Cited by 15 · see citing works

Base excision repair pathways of bacteria: New promise for an old problem

Kurthkoti, K., Kumar, P., Sang, P. B., & Varshney, U. (2020) · Future Medicinal Chemistry · doi:10.4155/fmc-2019-0267 · Cited by 12 · see citing works

Base excision repair of DNA in mammalian cells

Krokan, H. E., Nilsen, H. L., Skorpen, F., Otterlei, M., & Slupphaug, G. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01674-4 · Cited by 371 · see citing works

Enhanced activity of adenine-DNA glycosylase (Myh) by apurinic/apyrimidinic endonuclease (Ape1) in mammalian base excision repair of an A/GO mismatch

Yang, H. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.3.743 · Cited by 132 · see citing works

Glycosylase Repair

Laval, J., & Saparbaev, M. K. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-374984-0.00660-4

Linking uracil base excision repair and 5-fluorouracil toxicity in yeast

Seiple, L. A. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj430 · Cited by 127 · see citing works

The Influence of (5′R)- and (5′S)-5′,8-Cyclo-2′-Deoxyadenosine on UDG and hAPE1 Activity. Tandem Lesions are the Base Excision Repair System’s Nightmare

Karwowski, B. T. (2019) · Cells · doi:10.3390/cells8111303 · Cited by 19 · see citing works