The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Essential role of POU–domain factor Brn-3c in auditory and vestibular hair cell development
Open accessAbstract
The Brn-3 subfamily of POU–domain transcription factor genes consists of three highly homologous members—Brn-3a, Brn-3b, and Brn-3c—that are expressed in sensory neurons and in a small number of brainstem nuclei. This paper describes the role of Brn-3c in auditory and vestibular system development. In the inner ear, the Brn-3c protein is found only in auditory and vestibular hair cells, and the Brn-3a and Brn-3b proteins are found only in subsets of spiral and vestibular ganglion neurons. Mice carrying a targeted deletion of the Brn-3c gene are deaf and have impaired balance. These defects reflect a complete loss of auditory and vestibular hair cells during the late embryonic and early postnatal period and a secondary loss of spiral and vestibular ganglion neurons. Together with earlier work demonstrating a loss of trigeminal ganglion neurons and retinal ganglion cells in mice carrying targeted disruptions in the Brn-3a and Brn-3b genes, respectively, the Brn-3c phenotype reported here demonstrates that each of the Brn-3 genes plays distinctive roles in the somatosensory, visual, and auditory/vestibular systems.
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Metadata
- Authors
- Xiang, M., Gan, L., Li, D., Chen, Z.-Y., Zhou, L., O’Malley, B. W., Klein, W., & Nathans, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-08-19
- Volume
- 94
- Issue
- 17
- Pages
- 9445-9450
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2063902684
- Cited by
- 334
- References
- 40
- FWCI
- 7.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Xiang, M., Gan, L., Li, D., Chen, Z.-Y., Zhou, L., O’Malley, B. W., Klein, W., & Nathans, J. (1997). Essential role of POU–domain factor Brn-3c in auditory and vestibular hair cell development. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.17.9445
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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