A Short History of Nearly Every Sense—The Evolutionary History of Vertebrate Sensory Cell Types
Abstract
Evolving from filter feeding chordate ancestors, vertebrates adopted a more active life style. These ecological and behavioral changes went along with an elaboration of the vertebrate head including novel complex paired sense organs such as the eyes, inner ears, and olfactory epithelia. However, the photoreceptors, mechanoreceptors, and chemoreceptors used in these sense organs have a long evolutionary history and homologous cell types can be recognized in many other bilaterians or even cnidarians. After briefly introducing some of the major sensory cell types found in vertebrates, this review summarizes the phylogenetic distribution of sensory cell types in metazoans and presents a scenario for the evolutionary history of various sensory cell types involving several cell type diversification and fusion events. It is proposed that the evolution of novel cranial sense organs in vertebrates involved the redeployment of evolutionarily ancient sensory cell types for building larger and more complex sense organs.
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The sensory cells involved in light and sound have evolved from separate receptor-based systems.
“This is reinforced by what we know of the sensory cells involved, that they have evolved from separate receptor-based systems (Schlosser, 2018)”
From Consciousness as a Product of Evolution: Contents, Selector Circuits, and Trajectories in Experience Space (2021) · cites this paper as Schlosser, 2018
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Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells?
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The Piezo Mechanosensitive Ion Channels: May the Force Be with You!
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The Determination of Rod and Cone Photoreceptor Fate
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Vertebrate Cranial Placodes as Evolutionary Innovations—The Ancestor's Tale
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Ci-POU-IV expression identifies PNS neurons in embryos and larvae of the ascidian Ciona intestinalis
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C-opsin Expressing Photoreceptors in Echinoderms
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Beyond the Eye: Molecular Evolution of Extraocular Photoreception
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Studies on the receptors in Ciona intestinalis. IV. The ocellus in the adult
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Furcation and fusion: The phylogenetics of evolutionary novelty
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Evidence that polycystins are involved in Hydra cnidocyte discharge
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Vermeiren, S., Bellefroid, E., & Desiderio, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.587699 · Cited by 87 · see citing works
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Evolution of vision and hearing modalities in theropod dinosaurs
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Brn3/POU‐IV‐type POU homeobox genes—Paradigmatic regulators of neuronal identity across phylogeny
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Dendrite morphogenesis in Caenorhabditis elegans
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Revilla‐i‐Domingo, R., Rajan, V. B. V., Waldherr, M., Prohaczka, G., Musset, H., Orel, L., Gerrard, E. J., Smolka, M., Stockinger, A. W., Farlik, M., et al. (2021) · eLife · doi:10.7554/elife.66144 · Cited by 20 · see citing works
What is Multimodality?Preprint
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Koene, J. M., Jackson, D. J., Nakadera, Y., Cerveau, N., Madoui, M., Noël, B., Jamilloux, V., Poulain, J., Labadie, K., Silva, C. D., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-78520-1 · Cited by 10 · see citing works
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Gene Profiling in the Adipose Fin of Salmonid Fishes Supports Its Function as a Flow Sensor
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Neurons interact with the microbiome: an evolutionary-informed perspective
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Functional Anatomy of the Spinal Tracts based on Evolutionary Perspectives
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Evolutionary assembly of cooperating cell types in an animal chemical defense systemPreprint
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Schlosser, G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.24136-9 · Cited by 3 · see citing works
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Sensory Systems: Molecular Evolution in Vertebrates
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High Time for Hair Cells: An Introduction to the Symposium on Sensory Hair Cells
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Evolution of Eye and Origin of Myopia
Waikar, S., & Sharma, M. (2026) · Springer eBooks · doi:10.1007/978-981-95-5919-0_1
Movement is a Sensory Phenomenon
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de Oliveira, T. G. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1017756
- Authors
- Schlosser, G.
- Affiliations
- National University of Ireland (IE)
- Corresponding author
- Schlosser, Gerhard
- ORCID
- Schlosser, Gerhard
- Venue
- Integrative and Comparative Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-06-01
- Volume
- 58
- Issue
- 2
- Pages
- 301-316
- ISSN
- 1540-7063 (ISSN-L)
- 1557-7023
- OpenAlex
- W2800618514
- Cited by
- 33
- References
- 145
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 11 · 2020: 3 · 2019: 3 · 2018: 2
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Integrative and Comparative Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Health Sciences › Medicine › Urology › Comparative Animal Anatomy Studies
- Keywords
- photoreceptors, mechanoreceptors, chemoreceptors, eye evolution, inner ear evolution, olfactory epithelium, homology, chordate evolution, metazoan phylogeny
- MeSH terms
- Animals, Biological Evolution, Phylogeny, Sensory Receptor Cells, Vertebrates
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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