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The neural code between neocortical pyramidal neurons depends on neurotransmitter release probability
Open accessAbstract
Although signaling between neurons is central to the functioning of the brain, we still do not understand how the code used in signaling depends on the properties of synaptic transmission. Theoretical analysis combined with patch clamp recordings from pairs of neocortical pyramidal neurons revealed that the rate of synaptic depression, which depends on the probability of neurotransmitter release, dictates the extent to which firing rate and temporal coherence of action potentials within a presynaptic population are signaled to the postsynaptic neuron. The postsynaptic response primarily reflects rates of firing when depression is slow and temporal coherence when depression is fast. A wide range of rates of synaptic depression between different pairs of pyramidal neurons was found, suggesting that the relative contribution of rate and temporal signals varies along a continuum. We conclude that by setting the rate of synaptic depression, release probability is an important factor in determining the neural code.
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Cited by
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Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068
A mechanism for cognitive dynamics: neuronal communication through neuronal coherence.
Fries, P. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.08.011 · Cited by 4,284
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Abbott, L. F., & Nelson, S. B. (2000) · Nature Neuroscience · doi:10.1038/81453 · Cited by 2,263
Reconstruction and Simulation of Neocortical Microcircuitry
Markram, H., Muller, E., Ramaswamy, S., Reimann, M. W., Abdellah, M., Sanchez, C. A., Ailamaki, A., Alonso-Nanclares, L., Antille, N., Arsever, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.09.029 · Cited by 1,557
Self-citationAbbott, L. F., & Regehr, W. G. (2004) · Nature · doi:10.1038/nature03010 · Cited by 1,684
Metadata
- Authors
- Tsodyks, M. V., & Markram, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-01-21
- Volume
- 94
- Issue
- 2
- Pages
- 719-723
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2031543773
- Cited by
- 1,603
- References
- 0
- FWCI
- 15.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Tsodyks, M. V., & Markram, H. (1997). The neural code between neocortical pyramidal neurons depends on neurotransmitter release probability. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.2.719
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