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Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis
Open accessAbstract
HLA-G is a nonclassical major histocompatibility complex class I molecule selectively expressed on cytotrophoblasts at the feto–maternal interface, where it may play an important role in maternal tolerance of the fetus. We provide direct evidence under physiological conditions that supports the role of HLA-G in protecting cytotrophoblasts against natural killer (NK) cytolysis in 6 semiallogenic combinations of maternal uterine NK cells and their own trophoblast counterparts, as well as in 20 allogenic combinations of maternal uterine NK cells and trophoblasts from different mothers. We show that, in all cases studied, this HLA-G-mediated protection was abolished by treatment of cytotrophoblasts with an HLA-G-specific mAb. The HLA class I-negative K562 cell line transfected with the predominant HLA-G1 isoform results in similar protection and abolition from maternal uterine NK lysis. Because maternal uterine NK cells express killer inhibitory receptors for HLA-G, we conclude that their interactions contribute to the survival of the fetal semiallograft by confering immunological tolerance to its tissues.
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Citations
Cited by
REGULATION OF IMMUNE RESPONSES THROUGH INHIBITORY RECEPTORS
Long, E. O. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.875 · Cited by 939
HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells
Gornalusse, G. G., Hirata, R. K., Funk, S. E., Riolobos, L., Lopes, V. S., Manske, G., Prunkard, D., Colunga, A. G., Hanafi, L.-A., Clegg, D. O., et al. (2017) · Nature Biotechnology · doi:10.1038/nbt.3860 · Cited by 639
HLA-G expression in melanoma: A way for tumor cells to escape from immunosurveillance
Paul, P., Rouas-Freiss, N., Khalil-Daher, I., Moreau, P., Riteau, B., Le Gal, F. A., Avril, M. F., Dausset, J., Guillet, J. G., & Carosella, E. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4510 · Cited by 432
Self-citationBeyond the increasing complexity of the immunomodulatory HLA-G molecule
Carosella, E. D., Favier, B., Rouas-Freiss, N., Moreau, P., & LeMaoult, J. (2008) · Blood · doi:10.1182/blood-2007-12-127662 · Cited by 348
Self-citationKailayangiri, S., Altvater, B., Spurny, C., Jamitzky, S., Schelhaas, S., Jacobs, A. H., Wiek, C., Roellecke, K., Hanenberg, H., Hartmann, W., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2016.1250050 · Cited by 104
Metadata
- Authors
- Rouas-Freiss, N., Gonçalves, R. M.-B., Menier, C., Dausset, J., & Carosella, E. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-10-14
- Volume
- 94
- Issue
- 21
- Pages
- 11520-11525
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2158829408
- Cited by
- 701
- References
- 0
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis. https://app.cochat.ai/papers/10.1073/pnas.94.21.11520
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- Rouas-Freiss, N., Gonçalves, R. M.-B., Menier, C., Dausset, J., & Carosella, E. D. (1997). Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.21.11520
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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