The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
HLA-G expression in melanoma: A way for tumor cells to escape from immunosurveillance
Open accessAbstract
Considering the well established role of nonclassical HLA-G class I molecules in inhibiting natural killer (NK) cell function, the consequence of abnormal HLA-G expression in malignant cells should be the escape of tumors from immunosurveillance. To examine this hypothesis, we analyzed HLA-G expression and NK sensitivity in human malignant melanoma cells. Our analysis of three melanoma cell lines and ex vivo biopsy demonstrated that (i) IGR and M74 human melanoma cell lines exhibit a high level of HLA-G transcription with differential HLA-G isoform transcription and protein expression patterns, (ii) a higher level of HLA-G transcription ex vivo is detected in a skin melanoma metastasis biopsy compared with a healthy skin fragment from the same individual, and (iii) HLA-G protein isoforms other than membrane-bound HLA-G1 protect IGR from NK lysis. It thus appears of critical importance to consider the specific role of HLA-G expression in tumors in the design of future cancer immunotherapies.
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Cites
The Concept of Immunological Surveillance
Burnet, F. M. (2015) · Progress in Tumor Research · doi:10.1159/000386035 · Cited by 1,656
A Class I Antigen, HLA-G, Expressed in Human Trophoblasts
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Implications for immunosurveillance of altered HLA class I phenotypes in human tumours
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Self-citationThe activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.
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Protection from Natural Killer Cell-Mediated Lysis by HLA-G Expression on Target Cells
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Cited by
REGULATION OF IMMUNE RESPONSES THROUGH INHIBITORY RECEPTORS
Long, E. O. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.875 · Cited by 939
Early Events in the Pathogenesis of Epithelial Ovarian Cancer
Landen, C. N., Birrer, M. J., & Sood, A. K. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.9970 · Cited by 462
Beyond the increasing complexity of the immunomodulatory HLA-G molecule
Carosella, E. D., Favier, B., Rouas-Freiss, N., Moreau, P., & LeMaoult, J. (2008) · Blood · doi:10.1182/blood-2007-12-127662 · Cited by 348
Self-citationThe role of cancer-derived microRNAs in cancer immune escape
Yi, M., Xu, L., Jiao, Y., Luo, S., Li, A., & Wu, K. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00848-8 · Cited by 221
Kailayangiri, S., Altvater, B., Spurny, C., Jamitzky, S., Schelhaas, S., Jacobs, A. H., Wiek, C., Roellecke, K., Hanenberg, H., Hartmann, W., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2016.1250050 · Cited by 104
Metadata
- Authors
- Paul, P., Rouas-Freiss, N., Khalil-Daher, I., Moreau, P., Riteau, B., Le Gal, F. A., Avril, M. F., Dausset, J., Guillet, J. G., & Carosella, E. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-04-14
- Volume
- 95
- Issue
- 8
- Pages
- 4510-4515
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2160048269
- Cited by
- 432
- References
- 29
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: HLA-G expression in melanoma: A way for tumor cells to escape from immunosurveillance. https://app.cochat.ai/papers/10.1073/pnas.95.8.4510
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- Paul, P., Rouas-Freiss, N., Khalil-Daher, I., Moreau, P., Riteau, B., Le Gal, F. A., Avril, M. F., Dausset, J., Guillet, J. G., & Carosella, E. D. (1998). HLA-G expression in melanoma: A way for tumor cells to escape from immunosurveillance. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.8.4510
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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