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Cited by 363

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

A homeodomain gene Ptx 3 has highly restricted brain expression in mesencephalic dopaminergic neurons

Open access
Smidt, Marten P., van Schaick, Hermien S. A., Lanctôt, Christian, Tremblay, Jacques J., Cox, Joke J., van der Kleij, Arno A. M., Wolterink, Gerrit, Drouin, Jacques, Burbach, J. Peter H.·1997·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.94.24.13305
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Abstract

The mesencephalic dopaminergic (mesDA) system regulates behavior and movement control and has been implicated in psychiatric and affective disorders. We have identified a bicoid-related homeobox gene, Ptx3 , a member of the Ptx -subfamily, that is uniquely expressed in these neurons. Its expression starting at E11.5 in the developing mouse midbrain correlates with the appearance of mesDA neurons. The number of Ptx3 -expressing neurons is reduced in Parkinson patients, and these neurons are absent from 6-hydroxy-dopamine-lesioned rats, an animal model for this disease. Thus, Ptx3 is a unique transcription factor marking the mesDA neurons at the exclusion of other dopaminergic neurons, and it may be involved in developmental determination of this neuronal lineage.

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Crossref · 10.1073/pnas.94.24.13305

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Metadata

Authors
Smidt, M. P., van Schaick, H. S. A., Lanctôt, C., Tremblay, J. J., Cox, J. J., van der Kleij, A. A. M., Wolterink, G., Drouin, J., & Burbach, J. P. H.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1997-11-25
Volume
94
Issue
24
Pages
13305-13310
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.94.24.13305
OpenAlex
W2004275727
Cited by
363
References
1
FWCI
4.16
Type
journal article
Language
en
Open access
green

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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