Cited by 289Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchSchizophrenia research and treatment

Synaptic regulation of mesocorticolimbic dopamine neurons

White, F J·1996·Annual Review of Neuroscience

Abstract

The mesocorticolimbic dopamine system is thought to be involved in psychosis and drug addiction. Many intrinsic membrane properties and synaptic regulators have been identified and characterized in the midbrain ventral tegmental dopamine neurons that give rise to this system. Other neuronal properties remain subject to considerable debate. The present review brings together a large literature regarding neurophysiological studies of the synaptic mechanisms thought to regulate the activity of ventral tegmental dopamine neurons. This work is placed within the context of the behavioral responsiveness of midbrain dopamine neurons and the alterations produced in these neurons by repeated treatment with and withdrawal from antipsychotic drugs and drugs of abuse.

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Crossref · 10.1146/annurev.ne.19.030196.002201

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Authors
White, F. J.
Corresponding author
White, F J
Venue
Annual Review of Neuroscience
Published
1996-03
Volume
19
Issue
1
Pages
405-436
ISSN
  • 0147-006X (ISSN-L)
  • 1545-4126
OpenAlex
W2175469462
Cited by
289
References
95
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 8 · 2016: 6 · 2015: 9 · 2014: 7 · 2013: 1 · 2012: 12
FWCI
6.59
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k02da000207-04, 5r01mh040832-06)
  • U.S. Public Health Service
  • National Institute of Mental Health (MH-40832)
  • National Institute on Drug Abuse (DA-04093, DA00207)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
mesocorticolimbic dopamine system, ventral tegmental area, dopaminergic neurons, synaptic regulation, intrinsic membrane properties, psychosis, drug addiction, antipsychotic drugs, drug withdrawal, behavioral responsiveness, midbrain dopaminergic neurons
MeSH terms
Afferent Pathways, Animals, Dopamine, gamma-Aminobutyric Acid, Homeostasis, Humans, Limbic System, Mesencephalon, Neurons, Norepinephrine, Receptors, Dopamine, Serotonin, Substance Withdrawal Syndrome, Synapses, Tegmentum Mesencephali, Antipsychotic Agents, Excitatory Amino Acids, Substance-Related Disorders

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