Synaptic regulation of mesocorticolimbic dopamine neurons
Abstract
The mesocorticolimbic dopamine system is thought to be involved in psychosis and drug addiction. Many intrinsic membrane properties and synaptic regulators have been identified and characterized in the midbrain ventral tegmental dopamine neurons that give rise to this system. Other neuronal properties remain subject to considerable debate. The present review brings together a large literature regarding neurophysiological studies of the synaptic mechanisms thought to regulate the activity of ventral tegmental dopamine neurons. This work is placed within the context of the behavioral responsiveness of midbrain dopamine neurons and the alterations produced in these neurons by repeated treatment with and withdrawal from antipsychotic drugs and drugs of abuse.
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The majority of afferents onto DA neurons of the VTA-as much as 70% of synaptic inputs-are GABAergic and have a major impact on the activity of DA cells.
“Given that the majority of afferents onto DA neurons of the VTA -as much as 70 % of synaptic inputs -are GABAergic and have a major impact on the activity of DA cells (Henny et al., 2012; Mathon et al., 2003; White, 1996; Yang et al., 2018)”
From Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer’s Disease (2021) · cites this paper as White, 1996
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“Given that the majority of afferents onto DA neurons of the VTA – as much as 70% of synaptic inputs – are GABAergic and have a major impact on the activity of DA cells (Henny et al., 2012; Mathon et al., 2003; White, 1996; Yang et al., 2018), we next examined whether alterations in the GABAergic input on Tg2576 DA neu…”
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- Authors
- White, F. J.
- Corresponding author
- White, F J
- ORCID
- White, F J
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 1996-03
- Volume
- 19
- Issue
- 1
- Pages
- 405-436
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2175469462
- Cited by
- 289
- References
- 95
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 8 · 2016: 6 · 2015: 9 · 2014: 7 · 2013: 1 · 2012: 12
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k02da000207-04, 5r01mh040832-06)
- U.S. Public Health Service
- National Institute of Mental Health (MH-40832)
- National Institute on Drug Abuse (DA-04093, DA00207)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- mesocorticolimbic dopamine system, ventral tegmental area, dopaminergic neurons, synaptic regulation, intrinsic membrane properties, psychosis, drug addiction, antipsychotic drugs, drug withdrawal, behavioral responsiveness, midbrain dopaminergic neurons
- MeSH terms
- Afferent Pathways, Animals, Dopamine, gamma-Aminobutyric Acid, Homeostasis, Humans, Limbic System, Mesencephalon, Neurons, Norepinephrine, Receptors, Dopamine, Serotonin, Substance Withdrawal Syndrome, Synapses, Tegmentum Mesencephali, Antipsychotic Agents, Excitatory Amino Acids, Substance-Related Disorders
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