The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Large conductance voltage- and calcium-dependent K + channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus
Open accessAbstract
Large conductance voltage- and Ca 2+ -dependent K + (MaxiK) channels show sequence similarities to voltage-gated ion channels. They have a homologous S1-S6 region, but are unique at the N and C termini. At the C terminus, MaxiK channels have four additional hydrophobic regions (S7-S10) of unknown topology. At the N terminus, we have recently proposed a new model where MaxiK channels have an additional transmembrane region (S0) that confers β subunit regulation. Using transient expression of epitope tagged MaxiK channels, in vitro translation, functional, and “ in vivo ” reconstitution assays, we now show that MaxiK channels have seven transmembrane segments (S0-S6) at the N terminus and a S1-S6 region that folds in a similar way as in voltage-gated ion channels. Further, our results indicate that hydrophobic segments S9-S10 in the C terminus are cytoplasmic and unequivocally demonstrate that S0 forms an additional transmembrane segment leading to an exoplasmic N terminus.
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STRUCTURE AND FUNCTION OF VOLTAGE-GATED ION CHANNELS
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Cited by
Calcium-activated potassium channels
Vergara, C., Latorre, R., Marrion, N. V., & Adelman, J. P. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80056-1 · Cited by 954
MECHANISMS OF HAIR CELL TUNING
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Ca2+-Activated K+Channels: From Protein Complexes to Function
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Aging, ion channel expression, and vascular function
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Self-citationBK Ca Channels Activating at Resting Potential without Calcium in LNCaP Prostate Cancer Cells
Gessner, G., Schönherr, K., Soom, M., Hansel, A., Asim, M., Baniahmad, A., Derst, C., Hoshi, T., & Heinemann, S. H. (2006) · The Journal of Membrane Biology · doi:10.1007/s00232-005-0830-z · Cited by 55
Metadata
- Authors
- Meera, P., Wallner, M., Song, M., & Toro, L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-12-09
- Volume
- 94
- Issue
- 25
- Pages
- 14066-14071
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1998719957
- Cited by
- 310
- References
- 40
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Large conductance voltage- and calcium-dependent K + channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus. https://app.cochat.ai/papers/10.1073/pnas.94.25.14066
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- Meera, P., Wallner, M., Song, M., & Toro, L. (1997). Large conductance voltage- and calcium-dependent K + channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.25.14066
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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