Cited by 455Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stress

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Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: Enhancement by angiotensin II

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Pagano, Patrick J., Clark, Justin K., Cifuentes-Pagano, M. Eugenia, Clark, Stacie M., Callis, Gayle M., Quinn, Mark T.·1997·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.94.26.14483PMC PMC25029

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Abstract

Superoxide anion (O 2 − ) plays a key role in the endogenous suppression of endothelium-derived nitric oxide (NO) bioactivity and has been implicated in the development of hypertension. In previous studies, we found that O 2 − is produced predominantly in the adventitia of isolated rabbit aorta and acts as a barrier to NO. In the present studies, we characterize the enzyme responsible for O 2 − production in the adventitia and show that this enzyme is a constitutively active NADPH oxidase with similar composition as the phagocyte NADPH oxidase. Constitutive O 2 − -generating activity was localized to aortic adventitial fibroblasts and was enhanced by the potent vasoconstrictor angiotensin II. Immunohistochemistry of aortic sections demonstrated the presence of p22 phox , gp91 phox , p47 phox , and p67 phox localized exclusively in rabbit aortic adventitia, coincident with the site of staining for O 2 − production. Furthermore, immunodepletion of p67 phox from adventitial fibroblast particulates resulted in the loss of NADPH oxidase activity, which could be restored by the addition of recombinant p67 phox . Further study into the regulation of this adventitial source of O 2 − is important in elucidating the mechanisms regulating the bioactivity of NO and may contribute to our understanding of the pathogenesis of hypertension.

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Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.
Griendling, K. K., Minieri, C. A., Ollerenshaw, J. D., & Alexander, R. W. (1994) · Circulation Research · doi:10.1161/01.res.74.6.1141 · Cited by 2,735
Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.
Rajagopalan, S., Kurz, S. D., Münzel, T. F., Tarpey, M. M., Freeman, B. Α., Griendling, K. K., & Harrison, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118623 · Cited by 2,467
Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts
Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., & Goldschmidt-Clermont, P. J. (1997) · Science · doi:10.1126/science.275.5306.1649 · Cited by 1,588
Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension
Laursen, J. B., Rajagopalan, S., Galis, Z. S., Tarpey, M. M., Freeman, B. Α., & Harrison, D. G. (1997) · Circulation · doi:10.1161/01.cir.95.3.588 · Cited by 820
p22 Is a Critical Component of the Superoxide-generating NADH/NADPH Oxidase System and Regulates Angiotensin IIinduced Hypertrophy in Vascular Smooth Muscle Cells
Ushio‐Fukai, M., Zafari, A. M., Fukui, T., Ishizaka, N., & Griendling, K. K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.38.23317 · Cited by 766
Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2
Knaus, U. G., Heyworth, P. G., Evans, T., Curnutte, J. T., & Bokoch, G. (1991) · Science · doi:10.1126/science.1660188 · Cited by 673
Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression.
Rao, G. N., & Berk, B. C. (1992) · Circulation Research · doi:10.1161/01.res.70.3.593 · Cited by 649
A Novel Role for the β2 Integrin CD11b/CD18 in Neutrophil Apoptosis: A Homeostatic Mechanism in Inflammation
Coxon, A., Rieu, P., Barkalow, F. J., Askari, S., Sharpe, A. H., von Andrian, U. H., Arnaout, M. A., & Mayadas, T. N. (1996) · Immunity · doi:10.1016/s1074-7613(00)80278-2 · Cited by 627
Modulation of fibroblast proliferation by oxygen free radicals
Murrell, G. A. C., Francis, M. J. O., & Bromley, L. (1990) · Biochemical Journal · doi:10.1042/bj2650659 · Cited by 625
NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium
Mohazzab, K. M., Kaminski, P. M., & Wolin, M. S. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.6.h2568 · Cited by 536

Show all 48 references

Research works printed but not linked: 7

R A Miller, B E Brittigan J Invest Med 43, 39–49 (1995).
K M Mohazzab, M S Wolin Am J Physiol 267, L815–L822 (1994).
K M Mohazzab, P M Kaminski, M S Wolin Am J Physiol 266, H2568–H2572 (1994).
S A Jones, V B O’Donnell, J D Wood, J D Broughton, E J Hughes, O T G Jones Am J Physiol 271, H1626–H1634 (1996).
P J Pagano, Y Ito, K Tornheim, P M Gallop, A I Tauber, R A Cohen Am J Physiol 268, H2274–H2280 (1995).
H Wang, P J Pagano, Y Du, A J Cayatte, P Brecher, R A Cohen FASEB J 11, A477 (1997).
G W Hacker, I Zehbe, W H Muss, C Hauser-Kronberger, A-H Graf, O Dietze CellVision 2, 247–253 (1995).

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Authors: Pagano, P. J., Clark, J. K., Cifuentes-Pagano, M. E., Clark, S. M., Callis, G. M., & Quinn, M. T.
Affiliations: Boston Medical Center (US)
Vascular Biology Unit, Boston Medical Center, Boston, MA 02118; and Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717
ORCID: Pagano, Patrick J.
Callis, Gayle M.
Quinn, Mark T.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1997-12-23
Volume: 94
Issue: 26
Pages: 14483-14488
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.94.26.14483
PMC: PMC25029
OpenAlex: W2170708014
Cited by: 455
References: 48
Citations by year: 2026: 1 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 8 · 2019: 8 · 2018: 3 · 2017: 8 · 2016: 12 · 2015: 4 · 2014: 14 · 2013: 9 · 2012: 14
FWCI: 12.21
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (7r29hl055425-03)
National Heart, Lung, and Blood Institute (R29 HL55425-02, R01HL055425)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR042426)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: NADPH oxidase, superoxide, aortic adventitia, adventitial fibroblasts, angiotensin II, p67phox, p22phox, gp91phox, p47phox, nitric oxide, hypertension, vasoconstriction, rabbits
MeSH terms: Angiotensin II, Animals, Aorta, Cells, Cultured, Immunohistochemistry, NADPH Dehydrogenase, Phagocytes, Phosphoproteins, Rabbits, Vasoconstrictor Agents, NADPH Oxidases, Membrane Transport Proteins

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Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: Enhancement by angiotensin II

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