Cited by 455Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stress

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Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: Enhancement by angiotensin II

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Pagano, Patrick J., Clark, Justin K., Cifuentes-Pagano, M. Eugenia, Clark, Stacie M., Callis, Gayle M., Quinn, Mark T.·1997·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.94.26.14483PMC PMC25029

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Abstract

Superoxide anion (O 2 − ) plays a key role in the endogenous suppression of endothelium-derived nitric oxide (NO) bioactivity and has been implicated in the development of hypertension. In previous studies, we found that O 2 − is produced predominantly in the adventitia of isolated rabbit aorta and acts as a barrier to NO. In the present studies, we characterize the enzyme responsible for O 2 − production in the adventitia and show that this enzyme is a constitutively active NADPH oxidase with similar composition as the phagocyte NADPH oxidase. Constitutive O 2 − -generating activity was localized to aortic adventitial fibroblasts and was enhanced by the potent vasoconstrictor angiotensin II. Immunohistochemistry of aortic sections demonstrated the presence of p22 phox , gp91 phox , p47 phox , and p67 phox localized exclusively in rabbit aortic adventitia, coincident with the site of staining for O 2 − production. Furthermore, immunodepletion of p67 phox from adventitial fibroblast particulates resulted in the loss of NADPH oxidase activity, which could be restored by the addition of recombinant p67 phox . Further study into the regulation of this adventitial source of O 2 − is important in elucidating the mechanisms regulating the bioactivity of NO and may contribute to our understanding of the pathogenesis of hypertension.

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Authors: Pagano, P. J., Clark, J. K., Cifuentes-Pagano, M. E., Clark, S. M., Callis, G. M., & Quinn, M. T.
Affiliations: Boston Medical Center (US)
Vascular Biology Unit, Boston Medical Center, Boston, MA 02118; and Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717
ORCID: Pagano, Patrick J.
Callis, Gayle M.
Quinn, Mark T.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1997-12-23
Volume: 94
Issue: 26
Pages: 14483-14488
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.94.26.14483
PMC: PMC25029
OpenAlex: W2170708014
Cited by: 455
References: 48
Citations by year: 2026: 1 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 8 · 2019: 8 · 2018: 3 · 2017: 8 · 2016: 12 · 2015: 4 · 2014: 14 · 2013: 9 · 2012: 14
FWCI: 12.21
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (7r29hl055425-03)
National Heart, Lung, and Blood Institute (R29 HL55425-02, R01HL055425)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR042426)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: NADPH oxidase, superoxide, aortic adventitia, adventitial fibroblasts, angiotensin II, p67phox, p22phox, gp91phox, p47phox, nitric oxide, hypertension, vasoconstriction, rabbits
MeSH terms: Angiotensin II, Animals, Aorta, Cells, Cultured, Immunohistochemistry, NADPH Dehydrogenase, Phagocytes, Phosphoproteins, Rabbits, Vasoconstrictor Agents, NADPH Oxidases, Membrane Transport Proteins

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Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: Enhancement by angiotensin II

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