The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Drosophila host defense: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms
Open accessAbstract
Insects respond to microbial infection by the rapid and transient expression of several genes encoding potent antimicrobial peptides. Herein we demonstrate that this antimicrobial response of Drosophila is not aspecific but can discriminate between various classes of microorganisms. We first observe that the genes encoding antibacterial and antifungal peptides are differentially expressed after injection of distinct microorganisms. More strikingly, Drosophila that are naturally infected by entomopathogenic fungi exhibit an adapted response by producing only peptides with antifungal activities. This response is mediated through the selective activation of the Toll pathway.
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Cites
Schneider, D. S., Hudson, K. L., Lin, T. Y., & Anderson, K. V. (1991) · Genes & Development · doi:10.1101/gad.5.5.797 · Cited by 325
Cited by
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
Bellocchio, S., Montagnoli, C., Bozza, S., Gaziano, R., Rossi, G., Mambula, S. S., Vecchi, A., Mantovani, A., Levitz, S. M., & Romani, L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.3059 · Cited by 515
Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling
Weber, A. N. R., Tauszig-Delamasure, S., Hoffmann, J. A., Lelièvre, E., Gascan, H., Ray, K. P., Morse, M. A., Imler, J.-L., & Gay, N. J. (2003) · Nature Immunology · doi:10.1038/ni955 · Cited by 469
Self-citationECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
Kopp, E., Medzhitov, R., Carothers, J., Xiao, C., Douglas, I., Janeway, C. A., & Ghosh, S. (1999) · Genes & Development · doi:10.1101/gad.13.16.2059 · Cited by 334
Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function
Martin, M., Hiroyasu, A., Guzman, R. M., Roberts, S. A., & Goodman, A. G. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.029 · Cited by 173
Sorensen, O. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28422 · Cited by 152
Brun, S., Vidal, S., Spellman, P., Takahashi, K., Tricoire, H., & Lemaitre, B. (2006) · Genes to Cells · doi:10.1111/j.1365-2443.2006.00953.x · Cited by 91
Self-citationWinkler, B., Funke, D., Benmimoun, B., Spéder, P., Rey, S., Logan, M. A., & Klämbt, C. (2021) · Science Advances · doi:10.1126/sciadv.abh0050 · Cited by 53
The Drosophila Toll Pathway Controls but Does Not Clear Candida glabrata Infections
Quintin, J., Asmar, J., Matskevich, A. A., Lafarge, M.-C., & Ferrandon, D. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201861 · Cited by 42
Hanson, M. A., Kondo, S., & Lemaitre, B. (2022) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2022.0773 · Cited by 31
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Metadata
- Authors
- Lemaitre, B., Reichhart, J.-M., & Hoffmann, J. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-12-23
- Volume
- 94
- Issue
- 26
- Pages
- 14614-14619
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2096782178
- Cited by
- 1,034
- References
- 1
- FWCI
- 12.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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