The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses
Open accessAbstract
Neurotransmitter release requires the specific docking of synaptic vesicles to the presynaptic plasma membrane followed by a calcium-triggered fusion event. Herein we report a previously unsuspected interaction of the synaptic vesicle protein and likely calcium sensor synaptotagmin with the plasma membrane t-SNARE SNAP-25. This interaction appears to resolve the apparent paradox that synaptic vesicles are capable of docking even when VAMP (vesicle-associated membrane protein) or syntaxin is cleaved or deleted and suggests that two species of v-SNAREs (VAMP and synaptotagmin) and two species of t-SNAREs (SNAP-25 and syntaxin) interact to functionally dock synaptic vesicles.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sweeney, S. T., Broadie, K., Keane, J., Niemann, H., & O'Kane, C. J. (1995) · Neuron · doi:10.1016/0896-6273(95)90290-2 · Cited by 938
A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.
Davletov, B. A., & Südhof, T. C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74326-9 · Cited by 480
Chapman, E. R., An, S., Barton, N., & Jahn, R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47003-2 · Cited by 295
Cited by
Martin, T. F. J. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.231 · Cited by 522
Identification of SNAREs Involved in Synaptotagmin VII-regulated Lysosomal Exocytosis
Rao, S. K., Huynh, C., Proux-Gillardeaux, V., Galli, T., & Andrews, N. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400798200 · Cited by 320
Synaptotagmin I Functions as a Calcium Sensor to Synchronize Neurotransmitter Release
Yoshihara, M., & Littleton, J. T. (2002) · Neuron · doi:10.1016/s0896-6273(02)01065-6 · Cited by 285
Distinct Initial SNARE Configurations Underlying the Diversity of Exocytosis
Kasai, H., Takahashi, N., & Tokumaru, H. (2012) · Physiological Reviews · doi:10.1152/physrev.00007.2012 · Cited by 150
Pang, Z. P., Shin, O.-H., Meyer, A. C., Rosenmund, C., & Südhof, T. C. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3804-06.2006 · Cited by 113
“…Südhof, 1993; Sollner et al., 1993; Chapman and Jahn, 1994; Chapman et al., 1995; Li et al., 1995; Banerjee et al., 1996; Kee and Scheller, 1996; Schiavo et al., 1997; Fernandez et al., 2001; Wang et al., 2001; Zhang et al., 2002; Rickman and Davletov, 2003; Shin et al., 2003; Bai et al.,…”
Background
Metadata
- Authors
- Schiavo, G., Stenbeck, G., Rothman, J. E., & Söllner, T. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-02-04
- Volume
- 94
- Issue
- 3
- Pages
- 997-1001
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2154472809
- Cited by
- 307
- References
- 3
- FWCI
- 10.15
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses. https://app.cochat.ai/papers/10.1073/pnas.94.3.997
- The paper
- Schiavo, G., Stenbeck, G., Rothman, J. E., & Söllner, T. H. (1997). Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.3.997
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
