The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection
Open accessAbstract
Cytotoxic T lymphocytes (CTLs) are thought to play a crucial role in the termination of the acute primary HIV-1 syndrome, but clear evidence for this presumption has been lacking. Here we demonstrate positive selection of HIV-1 proviral sequences encoding variants within a CTL epitope in Nef, a gene product critical for viral pathogenicity, during and after seroconversion. These positively selected HIV-1 variants carried epitope sequence changes that either diminished or escaped CTL recognition. Other proviruses had mutations that abolished the Nef epitope altogether. These results provide clear evidence that CTLs exert selection pressure on the viral population in acute HIV-1 infection.
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Citations
Cites
Wu, T. T., & Kabat, E. A. (1970) · The Journal of Experimental Medicine · doi:10.1084/jem.132.2.211 · Cited by 1,340
Cited by
Goonetilleke, N., Liu, M. K. P., Salazar-Gonzalez, J. F., Ferrari, G., Giorgi, E., Ganusov, V. V., Keele, B. F., Learn, G. H., Turnbull, E. L., Salazar, M. G., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20090365 · Cited by 641
Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism
Sette, A., & Sidney, J. (1999) · Immunogenetics · doi:10.1007/s002510050594 · Cited by 635
Virus dynamics and drug therapy
Bonhoeffer, S., May, R. M., Shaw, G. M., & Nowak, M. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6971 · Cited by 632
Quantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry
Chattopadhyay, P. K., Price, D. A., Harper, T. F., Betts, M. R., Yu, J., Gostick, E., Perfetto, S. P., Goepfert, P., Koup, R. A., De Rosa, S. C., et al. (2006) · Nature Medicine · doi:10.1038/nm1371 · Cited by 372
Self-citationReversion of CTL escape–variant immunodeficiency viruses in vivo
Friedrich, T. C., Dodds, E. J., Yant, L. J., Vojnov, L., Rudersdorf, R., Cullen, C., Evans, D. T., Desrosiers, R. C., Mothé, B. R., Sidney, J., et al. (2004) · Nature Medicine · doi:10.1038/nm998 · Cited by 369
Metadata
- Authors
- Price, D. A., Goulder, P. J. R., Klenerman, P., Sewell, A. K., Easterbrook, P. J., Troop, M., Bangham, C. R. M., & Phillips, R. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-03-04
- Volume
- 94
- Issue
- 5
- Pages
- 1890-1895
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2079504777
- Cited by
- 688
- References
- 1
- FWCI
- 10.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Price, D. A., Goulder, P. J. R., Klenerman, P., Sewell, A. K., Easterbrook, P. J., Troop, M., Bangham, C. R. M., & Phillips, R. E. (1997). Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.5.1890
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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