The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Virus dynamics and drug therapy
Open accessAbstract
The recent development of potent antiviral drugs not only has raised hopes for effective treatment of infections with HIV or the hepatitis B virus, but also has led to important quantitative insights into viral dynamics in vivo. Interpretation of the experimental data depends upon mathematical models that describe the nonlinear interaction between virus and host cell populations. Here we discuss the emerging understanding of virus population dynamics, the role of the immune system in limiting virus abundance, the dynamics of viral drug resistance, and the question of whether virus infection can be eliminated from individual patients by drug treatment.
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Cites
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Cited by
Domingo, E., Sheldon, J., & Perales, C. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05023-11 · Cited by 1,009
Morgan, P., Van Der Graaf, P. H., Arrowsmith, J., Feltner, D. E., Drummond, K. S., Wegner, C. D., & Street, S. D. A. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2011.12.020 · Cited by 692
Nowak, M. A., Lloyd, A. L., Vasquez, G. M., Wiltrout, T. A., Wahl, L. M., Bischofberger, N., Williams, J., Kinter, A., Fauci, A. S., Hirsch, V. M., et al. (1997) · Journal of Virology · doi:10.1128/jvi.71.10.7518-7525.1997 · Cited by 284
Self-citationBiphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy
Tsiang, M., Rooney, J. F., Toole, J. J., & Gibbs, C. S. (1999) · Hepatology · doi:10.1002/hep.510290626 · Cited by 242
Evolution of Drug Resistance in Candida Albicans
Cowen, L. E., Anderson, J. B., & Kohn, L. M. (2002) · Annual Review of Microbiology · doi:10.1146/annurev.micro.56.012302.160907 · Cited by 151
Metadata
- Authors
- Bonhoeffer, S., May, R. M., Shaw, G. M., & Nowak, M. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-06-24
- Volume
- 94
- Issue
- 13
- Pages
- 6971-6976
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2060735144
- Cited by
- 632
- References
- 52
- FWCI
- 22.83
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
