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mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p
Open accessAbstract
Cdc7p is a protein kinase that is required for G 1 /S transition and initiation of DNA replication in Saccharomyces cerevisiae . The mechanisms whereby Cdc7p and its substrates exerts their effects are unknown. We report here the characterization in S. cerevisiae of a recessive mutation in a member of the MCM family, MCM5/ CDC46 , which bypasses the requirement for Cdc7p and its interacting factor Dbf4p. Because the MCM family of evolutionarily conserved proteins have been implicated in restricting DNA replication to once per cell cycle, our studies suggest that Cdc7p is required late in G 1 because in its absence the Mcm5p/Cdc46p blocks the initiation of DNA replication. Moreover, Mcm5p/Cdc46p may have both positive and negative effects on the ability of cell to initiate replication.
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Citations
Cites
The retinoblastoma protein and cell cycle control
Weinberg, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90385-2 · Cited by 4,862
Cited by
DNA Replication in Eukaryotic Cells
Bell, S. P., & Dutta, A. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135425 · Cited by 2,060
Moyer, S. E., Lewis, P. W., & Botchan, M. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602400103 · Cited by 699
Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo
Gavin, M. A., Clarke, S. R., Negrou, E., Gallegos, A., & Rudensky, A. (2002) · Nature Immunology · doi:10.1038/ni743 · Cited by 640
Regulation of Chromosome Replication
Kelly, T. J., & Brown, G. W. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.829 · Cited by 401
Initiating DNA synthesis: from recruiting to activating the MCM complex
Lei, M., & Tye, B. K. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.8.1447 · Cited by 365
Metadata
- Authors
- Hardy, C. F. J., Dryga, O., Seematter, S., Pahl, P. M. B., & Sclafani, R. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-04
- Volume
- 94
- Issue
- 7
- Pages
- 3151-3155
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2046707499
- Cited by
- 246
- References
- 1
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Hardy, C. F. J., Dryga, O., Seematter, S., Pahl, P. M. B., & Sclafani, R. A. (1997). mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.7.3151
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
