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Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers
Open accessAbstract
In confluent fibroblast monolayers, an increase in the selective uptake of free cholesterol (FC) from plasma low density lipoprotein (LDL) was accompanied by an increase in FC efflux. The rate of FC efflux was proportional to the FC content of the cell surface caveolae and to mRNA levels of caveolin, an FC-binding protein of caveolae. Inhibitors of LDL–FC internalization reduced the increase in caveolin mRNA levels and FC efflux. Oxysterols reduced caveolin mRNA levels, as well as transport of FC to the cell surface and FC efflux. DNA antisense to caveolin reduced caveolin mRNA and inhibited FC efflux. These data suggest that regulation of FC efflux can contribute to cellular FC homeostasis when LDL levels are modified over the physiological range, and they link this regulation to caveolin.
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Cited by
The differential miscibility of lipids as the basis for the formation of functional membrane rafts
Rietveld, A., & Simons, K. (1998) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/s0304-4157(98)00019-7 · Cited by 513
Intracellular cholesterol transport
Liscum, L., & Munn, N. J. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(99)00043-8 · Cited by 414
Atheroprotective mechanisms of HDL
Stein, O., & Stein, Y. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00065-9 · Cited by 316
Molecular mechanisms for ABCA1-mediated cholesterol efflux
Chen, L., Zhao, Z.-W., Zeng, P.-H., Zhou, Y.-J., & Yin, W.-J. (2022) · Cell Cycle · doi:10.1080/15384101.2022.2042777 · Cited by 134
Caveolae and intracellular trafficking of cholesterol
Fielding, C. J., & Fielding, P. E. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00140-5 · Cited by 116
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Metadata
- Authors
- Fielding, C. J., Bist, A., & Fielding, P. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-04-15
- Volume
- 94
- Issue
- 8
- Pages
- 3753-3758
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2003688961
- Cited by
- 239
- References
- 0
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers. https://app.cochat.ai/papers/10.1073/pnas.94.8.3753
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- Fielding, C. J., Bist, A., & Fielding, P. E. (1997). Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.8.3753
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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