Caveolae and intracellular trafficking of cholesterol

Fielding, Christopher J.; Fielding, Phoebe E.

doi:10.1016/s0169-409x(01)00140-5

Cited by 116Caveolin-1 and cellular processesCholesterol and Lipid MetabolismLipid Membrane Structure and Behavior

Caveolae and intracellular trafficking of cholesterol

Fielding, Christopher J., Fielding, Phoebe E.·2001·Advanced Drug Delivery Reviews

DOI 10.1016/s0169-409x(01)00140-5

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Abstract

Caveolae, free cholesterol (FC)-rich microdomains of the plasma membrane, are both a terminus for the intracellular transit of newly synthesized and recycling cellular FC, and a site for FC efflux to the extracellular medium. The same domains play key roles as locations for the assembly of signaling complexes and for the endocytosis of selected ligands. Caveolin, the major structural protein of caveolae, plays a regulatory role in growth, the cell cycle, and cell adhesion. Each of these functions is FC-dependent. Caveolae appear to act as both sensors and regulators of cellular FC content, and in this way mediate an array of membrane-dependent cell functions.

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Caveolin-1 (CAV1) is found in caveolae, cholesterol-rich membrane lipid formations that are involved in cholesterol traffic and homeostasis and regulation of inflammation.
“Caveolin-1 (CAV1) is found in caveolae, cholesterol-rich membrane lipid formations that are involved in cholesterol traffic and homeostasis58 and regulation of inflammation59 among other functions.”
From Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses (2016) · cites this paper as [58]

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Authors: Fielding, C. J., & Fielding, P. E.
Affiliations: University of California, San Francisco (US)
Corresponding author: Fielding, Christopher J.
Venue: Advanced Drug Delivery Reviews
Publisher: Elsevier BV
Published: 2001-07
Volume: 49
Issue: 3
Pages: 251-264
ISSN: 0169-409X (ISSN-L)
DOI: 10.1016/s0169-409x(01)00140-5
OpenAlex: W1963952319
Cited by: 116
References: 116
Citations by year: 2025: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 4 · 2014: 6 · 2013: 1 · 2012: 2
FWCI: 0.61
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Advanced Drug Delivery Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (HL 57976, R01HL057976)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Keywords: caveolae, cholesterol transport, free cholesterol, caveolin, cholesterol-rich membrane microdomains, cholesterol efflux, cholesterol biosynthesis, endocytosis, signaling complex assembly, cell adhesion, cell cycle regulation
MeSH terms: Animals, Cholesterol, Humans, Intracellular Fluid, Lipoproteins, Caveolae

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Caveolae and intracellular trafficking of cholesterol

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