The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Twenty proteins containing a C-terminal SOCS box form five structural classes
Open accessAbstract
The four members of the recently identified suppressor of cytokines signaling family (SOCS-1, SOCS-2, SOCS-3, and CIS, where CIS is cytokine-inducible SH2-containing protein) appear, by various means, to negatively regulate cytokine signal transduction. Structurally, the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. By using the SOCS box amino acid sequence consensus, we have searched DNA databases and have identified a further 16 proteins that contain this motif. These proteins fall into five classes based on the protein motifs found N-terminal of the SOCS box. In addition to four new SOCS proteins (SOCS-4 to SOCS-7) containing an SH2 domain and a SOCS box, we describe three new families of proteins that contain either WD-40 repeats (WSB-1 and -2), SPRY domains (SSB-1 to -3) or ankyrin repeats (ASB-1 to -3) N-terminal of the SOCS box. In addition, we show that a class of small GTPases also contains a SOCS box. The expression of representative members of each class of proteins differs markedly, as does the regulation of expression by cytokines. The function of the WSB, SSB, and ASB protein families remains to be determined.
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Regulation of JAK–STAT signalling in the immune system
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The molecular details of cytokine signaling via the JAK/STAT pathway
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Metadata
- Authors
- Hilton, D. J., Richardson, R. T., Alexander, W. S., Viney, E. M., Willson, T. A., Sprigg, N. S., Starr, R., Nicholson, S. E., Metcalf, D., & Nicola, N. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-01-06
- Volume
- 95
- Issue
- 1
- Pages
- 114-119
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2082390264
- Cited by
- 733
- References
- 19
- FWCI
- 22.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Hilton, D. J., Richardson, R. T., Alexander, W. S., Viney, E. M., Willson, T. A., Sprigg, N. S., Starr, R., Nicholson, S. E., Metcalf, D., & Nicola, N. A. (1998). Twenty proteins containing a C-terminal SOCS box form five structural classes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.1.114
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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