The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Second gene for gonadotropin-releasing hormone in humans
Open accessAbstract
Gonadotropin-releasing hormone (GnRH) is a decapeptide widely known for its role in regulating reproduction by serving as a signal from the hypothalamus to pituitary gonadotropes. In addition to hypothalamic GnRH (GnRH-I), a second GnRH form (pGln-His-Trp-Ser-His-Gly-Trp-Tyr-Pro-Gly; GnRH-II) with unknown function has been localized to the midbrain of many vertebrates. We show here that a gene encoding GnRH-II is expressed in humans and is located on chromosome 20p13, distinct from the GnRH-I gene that is on 8p21-p11.2. The GnRH-II genomic and mRNA structures parallel those of GnRH-I. However, in contrast to GnRH-I, GnRH-II is expressed at significantly higher levels outside the brain (up to 30×), particularly in the kidney, bone marrow, and prostate. The widespread expression of GnRH-II suggests it may have multiple functions. Molecular phylogenetic analysis shows that this second gene is likely the result of a duplication before the appearance of vertebrates, and predicts the existence of a third GnRH form in humans and other vertebrates.
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Cites
Quartet Puzzling: A Quartet Maximum-Likelihood Method for Reconstructing Tree Topologies
Strimmer, K., & von Haeseler, A. (1996) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a025664 · Cited by 2,531
Cited by
A novel mammalian receptor for the evolutionarily conserved type II GnRH
Millar, R., Lowe, S., Conklin, D., Pawson, A., Maudsley, S., Troskie, B., Ott, T., Millar, M., Lincoln, G., Sellar, R., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141048498 · Cited by 314
Gonadotropin‐releasing hormone: GnRH receptor signaling in extrapituitary tissues
Cheung, L. W. T., & Wong, A. S. T. (2008) · The FEBS Journal · doi:10.1111/j.1742-4658.2008.06677.x · Cited by 145
Matsuda, K., Nakamura, K., Shimakura, S.-I., Miura, T., Kageyama, H., Uchiyama, M., Shioda, S., & Ando, H. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.01.011 · Cited by 96
Gonadotropin-releasing hormone 2 suppresses food intake in the zebrafish, Danio rerio
Nishiguchi, R., Azuma, M., Yokobori, E., Uchiyama, M., & Matsuda, K. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00122 · Cited by 71
Kang, K. S., Shimizu, K., Azuma, M., Ui, Y., Nakamura, K., Uchiyama, M., & Matsuda, K. (2011) · Peptides · doi:10.1016/j.peptides.2010.10.013 · Cited by 31
Metadata
- Authors
- White, R. B., Eisen, J. A., Kasten, T. L., & Fernald, R. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-01-06
- Volume
- 95
- Issue
- 1
- Pages
- 305-309
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2089670528
- Cited by
- 408
- References
- 1
- FWCI
- 22.89
- Type
- journal article
- Language
- en
- Open access
- green
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- White, R. B., Eisen, J. A., Kasten, T. L., & Fernald, R. D. (1998). Second gene for gonadotropin-releasing hormone in humans. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.1.305
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