The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
From estrogen to androgen receptor: A new pathway for sex hormones in prostate
Open accessAbstract
While all three coactivators ARA 70 , steroid receptor coactivator 1, and RAC3/ACTR can enhance androgen receptor (AR) transcriptional activity at 1 nM dihydrotestosterone, we here demonstrate that only ARA 70 can induce AR transcriptional activity >30-fold in the presence of 10 nM 17β-estradiol (E2), but not diethylstilbestrol. The significance of this newly described E2-induced AR transcriptional activity in DU145 human prostate cancer cells was further strengthened by finding patients with Reifenstein partial-androgen-insensitive syndrome that fail in the E2-AR-ARA 70 pathway. Together, our data suggest, for the first time, testosterone/dihydrotestosterone may not be the only ligands for the AR. E2 represents another important natural ligand for AR that may play an essential role for the AR function and the development of the male reproductive system.
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Cited by
Androgen Receptor in Prostate Cancer
Heinlein, C. A., & Chang, C. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0032 · Cited by 1,780
Self-citationScher, H. I., & Sawyers, C. L. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.4777 · Cited by 1,025
Garcia-Segura, L. M., Azcoitia, I., & DonCarlos, L. L. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00025-3 · Cited by 938
Androgen Receptor (AR) Coregulators: An Overview
Heinlein, C. A., & Chang, C. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.2.0460 · Cited by 943
Self-citationHeemers, H. V., & Tindall, D. J. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0019 · Cited by 753
Metadata
- Authors
- Yeh, S., Miyamoto, H., Shima, H., & Chang, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-05-12
- Volume
- 95
- Issue
- 10
- Pages
- 5527-5532
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2137676273
- Cited by
- 267
- References
- 1
- FWCI
- 25.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Yeh, S., Miyamoto, H., Shima, H., & Chang, C. (1998). From estrogen to androgen receptor: A new pathway for sex hormones in prostate. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.10.5527
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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