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Cited by 189

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Late-onset minor and major depression: early evidence for common neuroanatomical substrates detected by using MRI

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Kumar, Anand, Jin, Zhisong, Bilker, Warren, Udupa, Jayaram, Gottlieb, Gary·1998·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.95.13.7654
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Abstract

The purpose of our study was to examine the neuroanatomical correlates of late-onset minor and major depression and to compare them with similar measures obtained from nondepressed controls. Our study groups were comprised of 18 patients with late-onset minor depression, 35 patients diagnosed with late-onset major depression, and 30 nondepressed controls. All subjects were scanned by using a 1.5-tesla MRI scanner. Absolute whole brain volume and normalized measures of prefrontal and temporal lobe volumes were obtained and used for comparison among groups. Our findings indicate that patients with minor depression present with specific neuroanatomical abnormalities that are comparable with the major depression group but significantly different from the controls. Normalized prefrontal lobe volumes show a significant linear trend with severity of depression, with volumes decreasing with illness severity. Whole brain volumes did not differ significantly among groups. These findings have broad implications for the biology of late-life depression and suggest that there may be common neurobiological substrates that underlie all clinically significant forms of late-onset mood disturbances.

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Metadata

Authors
Kumar, A., Jin, Z., Bilker, W., Udupa, J., & Gottlieb, G.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1998-06-23
Volume
95
Issue
13
Pages
7654-7658
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.95.13.7654
OpenAlex
W1981824915
Cited by
189
References
10
FWCI
4.18
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Late-onset minor and major depression: early evidence for common neuroanatomical substrates detected by using MRI. https://app.cochat.ai/papers/10.1073/pnas.95.13.7654
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Kumar, A., Jin, Z., Bilker, W., Udupa, J., & Gottlieb, G. (1998). Late-onset minor and major depression: early evidence for common neuroanatomical substrates detected by using MRI. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.13.7654

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.