Frontocingulate Dysfunction in Depression: Toward Biomarkers of Treatment Response

Pizzagalli, Diego A

doi:10.1038/npp.2010.166

Cited by 945Treatment of Major DepressionNeural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Frontocingulate Dysfunction in Depression: Toward Biomarkers of Treatment Response

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Pizzagalli, Diego A·2011·Neuropsychopharmacology

DOI 10.1038/npp.2010.166PMC PMC3036952

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Abstract

Increased rostral anterior cingulate cortex (rACC) activity has emerged as a promising predictor of treatment response in depression, but neither the reliability of this relationship nor the mechanisms supporting it have been thoroughly investigated. This review takes a three-pronged approach to these issues. First, I present a meta-analysis demonstrating that the relationship between resting rACC activity and treatment response is robust. Second, I propose that the rACC plays a key role in treatment outcome because of its 'hub' position in the default network. Specifically, I hypothesize that elevated resting rACC activity confers better treatment outcomes by fostering adaptive self-referential processing and by helping to recalibrate relationships between the default network and a 'task-positive network' that comprises dorsolateral prefrontal and dorsal cingulate regions implicated in cognitive control. Third, I support this hypothesis by reviewing neuropsychological, electrophysiological, and neuroimaging data on frontocingulate dysfunction in depression. The review ends with a discussion of the limitations of current work and future directions.

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Increased resting state functional connectivity in the perigenual anterior cingulate cortex predicted response to a variety of treatments including repetitive transcranial magnetic stimulation, pharmacotherapy, cognitive behavior therapy, and electroconvulsive therapy.
“In a coordinate-based meta-analysis [69], increased rsFC in the pgACC predicted response to a variety of treatments (e.g., repetitive transcranial magnetic stimulation (rTMS), pharmacotherapy, cognitive behavior therapy, electroconvulsive therapy (ECT)) (see also [16]).”
From Prefrontal cortex and depression (2022) · cites this paper as [16]
The meta-analysis Results report that higher pretreatment rostral ACC activity predicted better response across several treatments, including drugs and rTMS. They do not establish that increased resting-state functional connectivity predicted response; the paper discusses connectivity as a treatment-associated change instead. The Results also explicitly except ECT from the positive prediction finding and report no pretreatment rACC difference between CBT responders and nonresponders in the cited CBT study. (LLM, conf=0.90)
Experimental — accuracy not yet measured
The association between higher baseline anterior cingulate activity and better treatment response has been found by a more diverse set of studies, and has been meta-analytically confirmed.
“The association between higher baseline anterior cingulate activity and better treatment response has been found by a more diverse set of studies, and has been meta-analytically confirmed (13, 40).”
From SSRI Treatment Response Prediction in Depression Based on Brain Activation by Emotional Stimuli (2020) · cites this paper as [40]
Deficient recruitment of PFC (particularly dlPFC) regions has been coupled with hyperactivity in paralimbic (e.g., pgACC, sgACC) and limbic (e.g., amygdala) regions critically implicated in automatic processing of emotional cues.
“Of note, deficient recruitment of PFC (particularly, dlPFC) regions has been coupled with hyperactivity in paralimbic (e.g., pgACC, sgACC) and limbic (e.g., amygdala) regions critically implicated in automatic processing of emotional cues (for review, see [16,157]).”
From Prefrontal cortex and depression (2022) · cites this paper as [16]
Hyperactivation of, or a failure to deactivate, the pgACC has been reported in MDD across disparate affective tasks.
“Similarly, hyperactivation of, or a failure to deactivate, the pgACC has been reported in MDD across disparate affective tasks [16,179], including (1) affective evaluation and cognitive reappraisal of negative stimuli; (2) self-referential processing of negative attributes; (3) inhibition of negative words; and in response to (4) sad words and commission errors.”
From Prefrontal cortex and depression (2022) · cites this paper as [16]
In MDD subjects performing at the same level as controls, MDD is linked to potentiated pgACC, dACC, and left dlPFC; pgACC hyperactivation persists after remission.
“in studies in which MDD subjects performed at the same level as controls, MDD has been linked to potentiated pgACC, dACC and left dlPFC [16,237,238] and pgACC hyperactivation persisted after remission [239].”
From Prefrontal cortex and depression (2022) · cites this paper as [16]

Increased activity of pregenual ACC seems to be the most consistent general marker of good response to a variety of treatments.
“For now, an increased activity of pregenual ACC seems to be the most consistent general marker of good response to a variety of treatments, as supported by meta-analyses and shown in subsequent studies (Pizzagalli, 2011, Fu et al. 2013, Godlewska et al. 2016).”
From Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment (2021) · cites this paper as Pizzagalli, 2011
Increased reactivity of pgACC was perhaps the most reliable general predictor of clinical response to pharmacotherapy and psychotherapy alike.
“This was in line with other studies showing that increased reactivity of pgACC was perhaps the most reliable general predictor of clinical response to pharmacotherapy and psychotherapy alike (Pizzagalli 2011, Fu et al., 2013, Godlewska et al. 2016).”
From Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment (2021) · cites this paper as Pizzagalli 2011
Infliximab attaches to both soluble and transmembrane TNF-α domains, blocking TNF-α from reaching its receptors.
“Infliximab is a promising TNF antagonist that binds to soluble and transmembrane domains of TNF-α, thus preventing the binding of TNF-α to its receptors.74,75”
From Cognitive Impairment in Major Depressive Disorder (2019) · cites this paper as [74]
TNF-α is one of the most consistently reported cytokine abnormalities in MDD.
“Among the most consistently identified proinflammatory cytokine disturbances in MDD is tumor necrosis factor alpha (TNF-α).17,74”
From Cognitive Impairment in Major Depressive Disorder (2019) · cites this paper as [74]
Cognitive control has been reliably linked to the dlPFC and dACC.
“Finally, cognitive control has been reliably linked to the dlPFC and dACC (Pizzagalli, 2011; Ridderinkhof et al, 2004).”
From Neural Correlates of Three Promising Endophenotypes of Depression: Evidence from the EMBARC Study (2016) · cites this paper as Pizzagalli, 2011
The dlPFC has been strongly implicated in cognitive control.
“The dlPFC has been strongly implicated in cognitive control (Pizzagalli, 2011; Ridderinkhof et al, 2004)”
From Neural Correlates of Three Promising Endophenotypes of Depression: Evidence from the EMBARC Study (2016) · cites this paper as Pizzagalli, 2011
The extent to which these biases can be modulated by pharmacological therapies in patients is indicative of treatment response.
“Notably, the extent to which these biases can be modulated by pharmacological therapies in patients has been found to be indicative of treatment response (Sheline et al. 2001; Pizzagalli 2010)”
From Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers (2015) · cites this paper as Pizzagalli 2010
The ACC region is involved in both emotional processing and regulation and has been linked to self-referential processing and cognitive and attentional control with strong connections to both limbic and prefrontal brain regions.
“This region is involved in both emotional processing and regulation and has been linked to self-referential processing and cognitive and attentional control with strong connections to both limbic and prefrontal brain regions (Pizzagalli, 2011).”
From Meta-analyses of the neural mechanisms and predictors of response to psychotherapy in depression and anxiety (2018) · cites this paper as Pizzagalli, 2011

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Cognitive Inflexibility Among Ruminators and Nonruminators
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“Davis and Nolen-Hoeksema (2000) showed that people with high ruminative tendencies committed more perseverative errors in the Wisconsin Card Sorting Task.”
Background
Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression
Johansen-Berg, H., Gutman, D. A., Behrens, T. E. J., Matthews, P. M., Rushworth, M. F. S., Katz, E., Lozano, A. M., & Mayberg, H. S. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm167 · Cited by 561 · see citing works
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Reduced volume of orbitofrontal cortex in major depression
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Neurocognitive impairment in drug-free patients with major depressive disorder
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Altered Emotional Interference Processing in Affective and Cognitive-Control Brain Circuitry in Major Depression
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Use of fMRI to Predict Recovery From Unipolar Depression With Cognitive Behavior Therapy
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Quantitative Cerebral Anatomy in Depression
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Differences in Brain Glucose Metabolism Between Responders to CBT and Venlafaxine in a 16-Week Randomized Controlled Trial
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Frontal midline theta rhythms reflect alternative activation of prefrontal cortex and anterior cingulate cortex in humans
Asada, H., Fukuda, Y., Tsunoda, S., Yamaguchi, M., & Tonoike, M. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00679-5 · Cited by 411 · cited 1× · see citing works
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Mood-congruent attentional bias in dysphoria: maintained attention to and impaired disengagement from negative information.
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Ballmaier, M., Toga, A. W., Blanton, R. E., Sowell, E. R., Lavretsky, H., Peterson, J. R., Pham, D. L., & Kumar, A. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.1.99 · Cited by 384 · see citing works
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Depression-Related Variation in Brain Morphology Over 3 Years: Effects of Stress?
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Brain Imaging Correlates of Depressive Symptom Severity and Predictors of Symptom Improvement After Antidepressant Treatment
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Changes in regional cerebral blood flow on recovery from depression
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Altered Negative BOLD Responses in the Default-Mode Network during Emotion Processing in Depressed Subjects
Grimm, S., Boesiger, P., Beck, J., Schuepbach, D., Bermpohl, F., Walter, M., Ernst, J., Hell, D., Boeker, H., & Northoff, G. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.81 · Cited by 350 · see citing works
Brain morphometric abnormalities in geriatric depression: Long-term neurobiological effects of illness duration
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Decreased Regional Brain Metabolism After ECT
Nobler, M. S., Oquendo, M. A., Kegeles, L. S., Malone, K. M., Campbell, C., Sackeim, H. A., & Mann, J. J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.2.305 · Cited by 330 · see citing works
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Wu, J. C., Buchsbaum, M. S., Gillin, J. C., Tang, C. Y., Cadwell, S., Wiegand, M. H., Najafi, A., Klein, E., Hazen, K., & Bunney, W. E. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.8.1149 · Cited by 327 · see citing works
Antidepressant Effect on Connectivity of the Mood-Regulating Circuit: An fMRI Study
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Age Differences in Deactivation: A Link to Cognitive Control?
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Prefrontal dysfunction in depressed patients performing a complex planning task: a study using positron emission tomography
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Frontal White Matter Microstructure and Treatment Response of Late-Life Depression: A Preliminary Study
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The Relationship Between Aberrant Neuronal Activation in the Pregenual Anterior Cingulate, Altered Glutamatergic Metabolism, and Anhedonia in Major Depression
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Responses to depression in unipolar depressed patients: an investigation of Nolen-Hoeksema's response styles theory
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Effect of sertraline on regional metabolic rate in patients with affective disorder
Buchsbaum, M. S., Wu, J. C., Siegel, B. V., Hackett, E., Trenary, M., Abel, L., & Reynolds, C. A. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00097-2 · Cited by 302 · see citing works
Neuropsychological impairment in patients with major depressive disorder: the effects of feedback on task performance
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Microstructural White Matter Abnormalities and Remission of Geriatric Depression
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Cognitive impairment in the euthymic phase of affective disorder
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Effect of sleep deprivation on brain metabolism of depressed patients
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Efferent projections of infralimbic and prelimbic areas of the medial prefrontal cortex in the Japanese monkey, Macaca fuscata
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Dorsolateral Prefrontal Cortex and Anterior Cingulate Cortex White Matter Alterations in Late-Life Depression
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The central executive: A concept and some misconceptions
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Neuropsychological function in young patients with unipolar major depression
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Coupling of theta activity and glucose metabolism in the human rostral anterior cingulate cortex: An EEG/PET study of normal and depressed subjects
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Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression
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Anterior Cingulate Desynchronization and Functional Connectivity with the Amygdala During a Working Memory Task Predict Rapid Antidepressant Response to Ketamine
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Brain metabolic changes associated with symptom factor improvement in major depressive disorder
Brody, A. L., Saxena, S., Mandelkern, M. A., Fairbanks, L. A., Ho, M. L., & Baxter, L. R. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01117-9 · Cited by 213 · see citing works
Regional White Matter Hyperintensity Burden in Automated Segmentation Distinguishes Late-Life Depressed Subjects From Comparison Subjects Matched for Vascular Risk Factors
Sheline, Y. I., Price, J. L., Vaishnavi, S. N., Mintun, M. A., Barch, D. M., Epstein, A. A., Wilkins, C. H., Snyder, A. Z., Couture, L., Schechtman, K., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07010175 · Cited by 213 · see citing works
The Neural Circuitry of Executive Functions in Healthy Subjects and Parkinson's Disease
Leh, S. E., Petrides, M., & Strafella, A. P. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.88 · Cited by 211 · see citing works
Frontal and Limbic Activation During Inhibitory Control Predicts Treatment Response in Major Depressive Disorder
Langenecker, S. A., Kennedy, S. E., Guidotti, L. M., Briceño, E. M., Own, L. S., Hooven, T. A., Young, E. A., Akil, H., Noll, D. C., & Zubieta, J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.02.019 · Cited by 210 · see citing works
Prefrontal mechanisms for executive control over emotional distraction are altered in major depression
Wang, L., LaBar, K. S., Smoski, M., Rosenthal, M. Z., Dolcos, F., Lynch, T. R., Krishnan, R. R., & McCarthy, G. (2008) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2007.10.004 · Cited by 210 · see citing works
Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depression
Saxena, S., Brody, A. L., Ho, M. L., Zohrabi, N., Maidment, K. M., & Baxter, L. R. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.3.522 · Cited by 210 · see citing works
Inhibition of Action, Thought, and Emotion: A Selective Neurobiological Review.
Dillon, D., & Pizzagalli, D. (2007) · Applied & Preventive Psychology · doi:10.1016/j.appsy.2007.09.004 · Cited by 208 · see citing works
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Rostral and dorsal anterior cingulate cortex make dissociable contributions during antisaccade error commission
Polli, F. E., Barton, J. J. S., Cain, M. S., Thakkar, K. N., Rauch, S. L., & Manoach, D. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503657102 · Cited by 202 · see citing works
Common deactivation patterns during working memory and visual attention tasks: An intra‐subject fMRI study at 4 Tesla
Tomasi, D. G., Ernst, T., Caparelli, E. C., & Chang, L. (2006) · Human Brain Mapping · doi:10.1002/hbm.20211 · Cited by 201 · see citing works
Voxel-based analyses of gray/white matter volume and diffusion tensor data in major depression
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Rostral anterior cingulate cortex activity mediates the relationship between the depressive symptoms and the medial prefrontal cortex activity
Yoshimura, S., Okamoto, Y., Onoda, K., Matsunaga, M., Ueda, K., Suzuki, S.-I., & ShigetoYamawaki (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.06.017 · Cited by 199 · see citing works
Greater activation of the “default” brain regions predicts stop signal errors
Li, C.-S. R., Yan, P., Bergquist, K. L., & Sinha, R. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.021 · Cited by 194 · see citing works
Independence in ROI analysis: where is the voodoo?
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Effects of sleep deprivation on the limbic system and the frontal lobes in affective disorders: A study with Tc-99m-HMPAO SPECT
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Frontal white matter anisotropy and symptom severity of late-life depression: a magnetic resonance diffusion tensor imaging study
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White Matter Abnormalities in First-Episode, Treatment-Naive Young Adults With Major Depressive Disorder
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Neural basis of the emotional Stroop interference effect in major depression
Mitterschiffthaler, M. T., Williams, S. C. R., Walsh, N. D., Cleare, A. J., Donaldson, C., Scott, J., & Fu, C. H. Y. (2008) · Psychological Medicine · doi:10.1017/s0033291707001523 · Cited by 190 · see citing works
Late-onset minor and major depression: early evidence for common neuroanatomical substrates detected by using MRI
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Altered Functioning of the Executive Control Circuit in Late-Life Depression: Episodic and Persistent Phenomena
Aizenstein, H. J., Butters, M. A., Wu, M., Mazurkewicz, L. M., Stenger, V. A., Gianaros, P. J., Becker, J. T., Reynolds, C. F., & Carter, C. S. (2009) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31817b60af · Cited by 187 · see citing works
An fMRI study of prefrontal brain activation during multiple tasks in patients with major depressive disorder
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Neural Systems Supporting the Control of Affective and Cognitive Conflicts
Ochsner, K. N., Hughes, B., Robertson, E. R., Cooper, J. C., & Gabrieli, J. D. E. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21129 · Cited by 185 · see citing works
Conflict and Cognitive Control in the Brain
van Veen, V., & Carter, C. S. (2006) · Current Directions in Psychological Science · doi:10.1111/j.1467-8721.2006.00443.x · Cited by 183 · see citing works
Attenuated Left Prefrontal Activation during a Verbal Fluency Task in Patients with Depression
Okada, G., Okamoto, Y., Morinobu, S., Yamawaki, S., & Yokota, N. (2003) · Neuropsychobiology · doi:10.1159/000068871 · Cited by 178 · see citing works
Aberrant functional connectivity of dorsolateral prefrontal and cingulate networks in patients with major depression during working memory processing
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Brain Activations in Schizophrenia During a Graded Memory Task Studied With Functional Neuroimaging
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HPA axis dysfunction in unmedicated major depressive disorder and its normalization by pharmacotherapy correlates with alteration of neural activity in prefrontal cortex and limbic/paralimbic regions
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Neurocognitive impairment in euthymic young adults with bipolar spectrum disorder and recurrent major depressive disorder
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Correlation of cerebral blood flow and treatment effects of repetitive transcranial magnetic stimulation in depressed patients
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Brain Activation Measured With fMRI During a Mental Arithmetic Task in Schizophrenia and Major Depression
Hugdahl, K., Rund, B. R., Lund, A., Asbjørnsen, A. E., Egeland, J., Ersland, L., Landrø, N. I., Roness, A., Stordal, K. I., Sundet, K. S., et al. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.286 · Cited by 162 · see citing works
Medial frontal cortex activity and loss-related responses to errors
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Cognitive functioning in young and middle-aged unmedicated out-patients with major depression: testing the effort and cognitive speed hypotheses
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Predictors of nonresponse to cognitive behavioural therapy or venlafaxine using glucose metabolism in major depressive disorder
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Rostral anterior cingulate cortex theta current density and response to antidepressants and placebo in major depression
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The Way in Which Intervention Studies Have "Personality" and Why It Is Important to Meta-Analysis
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White Matter Abnormalities in First-Episode, Treatment-Naive Young Adults With Major Depressive Disorder
Ma, N. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.164.5.823 · Cited by 152 · see citing works
Rumination and impaired resource allocation in depression.
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Neural markers of symptomatic improvement during antidepressant therapy in severe depression: subgenual cingulate and visual cortical responses to sad, but not happy, facial stimuli are correlated with changes in symptom score
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Placebos, Drug Effects, and Study Design: A Clinician’s Guide
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Fronto-cingulate effective connectivity in major depression: A study with fMRI and dynamic causal modeling
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Smaller Cingulate Volumes in Unipolar Depressed Patients
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Response Inhibition Predicts Poor Antidepressant Treatment Response in Very Old Depressed Patients
Sneed, J. R., Roose, S. P., Keilp, J. G., Krishnan, K. R. R., Alexopoulos, G. S., & Sackeim, H. A. (2007) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3180302513 · Cited by 146 · see citing works
Prediction of treatment response in major depression: Integration of concepts
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Response conflict and frontocingulate dysfunction in unmedicated participants with major depression
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Neuroanatomical characteristics of geriatric apathy and depression: A magnetic resonance imaging study
Lavretsky, H., Ballmaier, M., Pham, D., Toga, A., & Kumar, A. (2007) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3180325a16 · Cited by 143 · see citing works
Early adverse events, HPA activity and rostral anterior cingulate volume in MDD
Treadway, M. T., Grant, M. M., Ding, Z., Hollon, S. D., Gore, J. C., & Shelton, R. C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004887 · Cited by 142 · see citing works
Cerebral blood flow changes during vagus nerve stimulation for depression
Conway, C. R., Sheline, Y. I., Chibnall, J. T., George, M. S., Fletcher, J. W., & Mintun, M. A. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2005.12.007 · Cited by 140 · see citing works
Self-referential processing of negative stimuli within the ventral anterior cingulate gyrus and right amygdala
Yoshimura, S., Ueda, K., Suzuki, S.-I., Onoda, K., Okamoto, Y., & Yamawaki, S. (2009) · Brain and Cognition · doi:10.1016/j.bandc.2008.07.010 · Cited by 140 · see citing works

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Power failure: why small sample size undermines the reliability of neuroscience
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Gray matter abnormalities in major depressive disorder: A meta-analysis of voxel based morphometry studies
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Toward a Neuroimaging Treatment Selection Biomarker for Major Depressive Disorder
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Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine
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Treatment selection in depression.
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Facial emotion processing in major depression: a systematic review of neuroimaging findings
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Emotional valence modulates brain functional abnormalities in depression: Evidence from a meta-analysis of fMRI studies
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Predictive neural biomarkers of clinical response in depression. a meta-analysis of functional and structural neuroimaging studies of pharmacological and psychological therapies
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Self-referential processing, rumination, and cortical midline structures in major depression
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The Mindful Brain and Emotion Regulation in Mood Disorders
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Cognitive Impairment in Major Depressive Disorder
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Resting state networks in major depressive disorder
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Pretreatment Rostral Anterior Cingulate Cortex Theta Activity in Relation to Symptom Improvement in Depression: A Randomized Clinical Trial
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Neural Systems Supporting the Control of Affective and Cognitive Conflicts
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Early changes in emotional processing as a marker of clinical response to SSRI treatment in depression
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Authors: Pizzagalli, D. A.
Affiliations: Harvard University (US)
Corresponding author: Pizzagalli, Diego A
ORCID: Pizzagalli, Diego A
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2010-09-22
Volume: 36
Issue: 1
Pages: 183-206
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/npp.2010.166
PMC: PMC3036952
OpenAlex: W2162541816
Cited by: 945
References: 294
Citations by year: 2026: 49 · 2025: 63 · 2024: 51 · 2023: 42 · 2022: 45 · 2021: 87 · 2020: 58 · 2019: 60 · 2018: 55 · 2017: 61 · 2016: 71 · 2015: 83 · 2014: 73 · 2013: 74 · 2012: 45
FWCI: 5.23
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
National Institute of Mental Health (R01MH068376, R21MH078979, R01 MH68376)
National Center for Complementary and Integrative Health (R21AT002974)
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: depression, rostral anterior cingulate cortex, treatment response prediction, biomarkers, resting-state brain activity, default mode network, task-positive network, self-referential processing, cognitive control, dorsolateral prefrontal cortex
MeSH terms: Antidepressive Agents, Cognition, Major Depressive Disorder, Gyrus Cinguli, Humans, Nerve Net, Outcome Assessment, Health Care, Prefrontal Cortex, Biomarkers, Pharmacological

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Frontocingulate Dysfunction in Depression: Toward Biomarkers of Treatment Response

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