The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Propagation and recovery of intact, infectious Epstein–Barr virus from prokaryotic to human cells
Open accessAbstract
With current techniques, genetic alterations of herpesviruses are difficult to perform, mostly because of the large size of their genomes. To solve this problem, we have designed a system that allows the cloning of any γ-herpesvirus in Escherichia coli onto an F factor-derived plasmid. Immortalized B cell lines were readily established with recombinant Epstein–Barr virus (EBV), demonstrating that the F factor-cloned EBV genome has all the characteristics of wild-type EBV. Because any genetic modification is possible in E. coli , this experimental approach opens the way to the genetic analysis of all EBV functions. Moreover, it is now feasible to generate attenuated EBV strains in vitro such that vaccine strains can be designed. Because we incorporated the genes for hygromycin resistance and green fluorescent protein onto the E. coli cloned EBV genome, the still open question of the EBV target cells other than B lymphocytes will be addressed.
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Mocarski, E. S., Post, L. E., & Roizman, B. (1980) · Cell · doi:10.1016/0092-8674(80)90172-5 · Cited by 186
Cited by
Latency and lytic replication in Epstein–Barr virus-associated oncogenesis
Münz, C. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0249-7 · Cited by 469
Borst, E.-M., Hahn, G., Koszinowski, U. H., & Messerle, M. (1999) · Journal of Virology · doi:10.1128/jvi.73.10.8320-8329.1999 · Cited by 384
Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5
Barth, S., Pfuhl, T., Mamiani, A., Ehses, C., Roemer, K., Kremmer, E., Jaker, C., Hock, J., Meister, G., & Grasser, F. A. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm1080 · Cited by 351
Adler, H., Messerle, M., Wagner, M., & Koszinowski, U. H. (2000) · Journal of Virology · doi:10.1128/jvi.74.15.6964-6974.2000 · Cited by 317
Epstein–Barr virus reprograms human B lymphocytes immediately in the prelatent phase of infection
Mrozek-Gorska, P., Buschle, A., Pich, D., Schwarzmayr, T., Fechtner, R., Scialdone, A., & Hammerschmidt, W. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901314116 · Cited by 210
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Metadata
- Authors
- Delecluse, H.-J., Hilsendegen, T., Pich, D., Zeidler, R., & Hammerschmidt, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-07-07
- Volume
- 95
- Issue
- 14
- Pages
- 8245-8250
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2085161568
- Cited by
- 467
- References
- 1
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Delecluse, H.-J., Hilsendegen, T., Pich, D., Zeidler, R., & Hammerschmidt, W. (1998). Propagation and recovery of intact, infectious Epstein–Barr virus from prokaryotic to human cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.14.8245
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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