The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5
Open accessAbstract
MicroRNAs (miRNAs) have been implicated in sequence-specific cleavage, translational repression or deadenylation of specific target mRNAs resulting in post-transcriptional gene silencing. Epstein-Barr virus (EBV) encodes 23 miRNAs of unknown function. Here we show that the EBV-encoded miRNA miR-BART2 down-regulates the viral DNA polymerase BALF5. MiR-BART2 guides cleavage within the 3'-untranslated region (3'UTR) of BALF5 by virtue of its complete complementarity to its target. Induction of the lytic viral replication cycle results in a reduction of the level of miR-BART2 with a strong concomitant decrease of cleavage of the BALF5 3'UTR. Expression of miR-BART2 down-regulates the activity of a luciferase reporter gene containing the BALF5 3'UTR. Forced expression of miR-BART2 during lytic replication resulted in a 40-50% reduction of the level of BALF5 protein and a 20% reduction of the amount of virus released from EBV-infected cells. Our results are compatible with the notion that EBV-miR-BART2 inhibits transition from latent to lytic viral replication.
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Cites
1 retracted
Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript
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Argonaute2 is the catalytic engine of mammalian RNAi
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Self-citationHuman Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs
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Cited by
Bartel, D. P. (2018) · Cell · doi:10.1016/j.cell.2018.03.006 · Cited by 3,751
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An Epstein-Barr virus–encoded microRNA targets PUMA to promote host cell survival
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Viral and Cellular MicroRNAs as Determinants of Viral Pathogenesis and Immunity
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Asgari, S. (2013) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2012.10.005 · Cited by 274
Metadata
- Authors
- Barth, S., Pfuhl, T., Mamiani, A., Ehses, C., Roemer, K., Kremmer, E., Jaker, C., Hock, J., Meister, G., & Grasser, F. A.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-11-26
- Volume
- 36
- Issue
- 2
- Pages
- 666-675
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2090975474
- Cited by
- 351
- References
- 26
- FWCI
- 12.07
- Type
- journal article
- Language
- en
- Open access
- gold
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- Barth, S., Pfuhl, T., Mamiani, A., Ehses, C., Roemer, K., Kremmer, E., Jaker, C., Hock, J., Meister, G., & Grasser, F. A. (2007). Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5. Nucleic Acids Research. https://doi.org/10.1093/nar/gkm1080
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