The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Can ends justify the means?: Telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells
Open accessAbstract
Finite replicative lifespan, or senescence, of mammalian cells in culture is a phenomenon that has generated much curiosity since its description. The obvious significance of senescence to organismal aging and the development of cancer has engendered a long-lasting and lively debate about its mechanisms. Recent discoveries concerning the phenotypes of telomerase knockout mice, the consequences of telomerase reexpression in somatic cells, and genes that regulate senescence have provided striking molecular insights but also have uncovered important new questions. The objective of this review is to reconcile old observations with new molecular details and to focus attention on the key remaining puzzles.
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Cites
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Cited by
The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior
Grandori, C., Cowley, S. M., James, L. P., & Eisenman, R. N. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.653 · Cited by 1,333
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Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
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Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
Ohtani, N., Zebedee, Z., Huot, T. J. G., Stinson, J. A., Sugimoto, M., Ohashi, Y., Sharrocks, A. D., Peters, G., & Hara, E. (2001) · Nature · doi:10.1038/35059131 · Cited by 654
Metadata
- Authors
- Sedivy, J. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-08-04
- Volume
- 95
- Issue
- 16
- Pages
- 9078-9081
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2013880323
- Cited by
- 183
- References
- 16
- FWCI
- 14.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Sedivy, J. M. (1998). Can ends justify the means?: Telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.16.9078
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