The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Interleukin 10 secretion in relation to human IL-10 locus haplotypes
Open accessAbstract
Stimulation of human blood cultures with bacterial lipopolysaccharide (LPS) shows large inter-individual variation in interleukin 10 (IL-10) secretion, which has been shown to have a genetic component of over 70%. Alleles at two microsatellite loci in the 4 kb immediately upstream of the human IL-10 transcription initiation site in 132 individuals from 56 Dutch families were defined and assigned as haplotypes. LPS-induced IL-10 secretion was measured by ELISA and related to the IL-10 promoter haplotypes present in 78 unrelated individuals obtained from these families. Analysis showed that LPS-induced IL-10 secretion from unrelated individuals varied with IL-10 promoter haplotypes (P= 0.024; Kruskal-Wallis test). Two observations were made in relation to secreted IL-10 levels and promoter haplotypes; first, those haplotypes containing the allele IL10.R3 were associated with lower IL-10 secretion than haplotypes containing any other IL10.R allele. Second, the haplotype IL10.R2/IL10.G14 was associated with highest IL-10 secretion overall, whereas the haplotype IL10.R3/IL10.G7 was associated with lowest IL-10 secretion. These data demonstrate that the ability to secrete IL-10 can vary in man according to the genetic composition of the IL-10 locus.
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de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., & de Vries, J. E. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.5.1209 · Cited by 3,762
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Transcription of the IL10 gene reveals allele-specific regulation at the mRNA level
Kurreeman, F. A. S., Schonkeren, J. J. M., Heijmans, B. T., Toes, R. E. M., & Huizinga, T. W. J. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh187 · Cited by 263
Self-citationReuss, E., Fimmers, R., Kruger, A., Becker, C., Rittner, C., & Höhler, T. (2002) · Genes & Immunity · doi:10.1038/sj.gene.6363920 · Cited by 247
Metadata
- Authors
- Eskdale, J., Gallagher, G., Verweij, C. L., Keijsers, V., Westendorp, R. G. J., & Huizinga, T. W. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-08-04
- Volume
- 95
- Issue
- 16
- Pages
- 9465-9470
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2042474497
- Cited by
- 467
- References
- 1
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Eskdale, J., Gallagher, G., Verweij, C. L., Keijsers, V., Westendorp, R. G. J., & Huizinga, T. W. J. (1998). Interleukin 10 secretion in relation to human IL-10 locus haplotypes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.16.9465
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