The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia
Open accessAbstract
The inducible isoform of the enzyme cyclooxygenase-2 (COX2) is an immediate early gene induced by synaptic activity in the brain. COX2 activity is an important mediator of inflammation, but it is not known whether COX2 activity is pathogenic in brain. To study the role of COX2 activity in ischemic injury in brain, expression of COX2 mRNA and protein and the effect of treatment with a COX2 inhibitor on neuronal survival in a rat model of global ischemia were determined. Expression of both COX2 mRNA and protein was increased after ischemia in CA1 hippocampal neurons before their death. There was increased survival of CA1 neurons in rats treated with the COX2-selective inhibitor SC58125 {1-[(4-methylsulfonyl) phenyl]-3-trifluoro-methyl-5-[(4-fluoro)phenyl] pyrazole} before or after global ischemia compared with vehicle controls. Furthermore, hippocampal prostaglandin E 2 concentrations 24 h after global ischemia were decreased in drug-treated animals compared with vehicle-treated controls. These results suggest that COX2 activity contributes to CA1 neuronal death after global ischemia.
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Metadata
- Authors
- Nakayama, M., Uchimura, K., Zhu, R. L., Nagayama, T., Rose, M. E., Stetler, R. A., Isakson, P. C., Chen, J., & Graham, S. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-09
- Volume
- 95
- Issue
- 18
- Pages
- 10954-10959
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1993213847
- Cited by
- 337
- References
- 40
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia. https://app.cochat.ai/papers/10.1073/pnas.95.18.10954
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- Nakayama, M., Uchimura, K., Zhu, R. L., Nagayama, T., Rose, M. E., Stetler, R. A., Isakson, P. C., Chen, J., & Graham, S. H. (1998). Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.18.10954
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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