Blood–Brain Barrier Pathology in Alzheimer's and Parkinson's Disease: Implications for Drug Therapy
Open accessAbstract
The blood–brain barrier (BBB) is a tightly regulated barrier in the central nervous system. Though the BBB is thought to be intact during neurodegenerative diseases such as Alzheimer's (AD) and Parkinson's disease (PD), recent evidence argues otherwise. Dysfunction of the BBB may be involved in disease progression, eliciting of peripheral immune response, and, most importantly, altered drug efficacy. In this review, we will give a brief overview of the BBB, its components, and their functions. We will critically evaluate the current literature in AD and PD BBB pathology resulting from insult, neuroinflammation, and neurodegeneration. Specifically, we will discuss alterations in tight junction, transport and endothelial cell surface proteins, and vascular density changes, all of which result in altered permeability. Finally, we will discuss the implications of BBB dysfunction in current and future therapeutics. Developing a better appreciation of BBB dysfunction in AD and PD may not only provide novel strategies in treatment, but will prove an interesting milestone in understanding neurodegenerative disease etiology and progression.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The disruption of the blood-brain barrier is involved in the pathophysiology of various neurological diseases such as Alzheimer's disease and traumatic brain and spinal cord injuries.
“The disruption of the BBB is involved in the pathophysiology of various neurological diseases such as Alzheimer's disease (AD), 45 and traumatic brain and spinal cord injuries. 46”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [45]
Cites
Blennow, K., de Leon, M. J., & Zetterberg, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69113-7 · Cited by 3,134 · see citing works
McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990 · see citing works
Thomas, A. C., & Campbell, J. H. (2000) · Cited by 2,800 · see citing works
Stages in the development of Parkinson’s disease-related pathology
Braak, H., Ghebremedhin, E., Rüb, U., Bratzke, H., & Del Tredici, K. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0956-9 · Cited by 2,689 · see citing works
Hoffmeyer, S., Burk, O., von Richter, O., Arnold, H., Brockmöller, J., Johne, A., Cascorbi, I., Gerloff, T., Roots, I., Eichelbaum, M. F., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3473 · Cited by 2,366 · see citing works
Schinkel, A. H., Smit, J., van Tellingen, O., Beijnen, J. H., Wagenaar, E., van Deemter, L., Mol, C. A. A. M., van der Valk, M. A., Robanus-Maandag, E. C., Riele, H. T., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90212-7 · Cited by 2,284 · see citing works
Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice
Nitta, T., Hata, M., Gotoh, S., Seo, Y., Sasaki, H., Hashimoto, N., Furuse, M., & Tsukita, S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302070 · Cited by 1,917 · see citing works
Cherny, R. A., Atwood, C. S., Xilinas, M. E., Gray, D. N., Jones, W. D., McLean, C. A., Barnham, K. J., Volitakis, I., Fraser, F. W., Kim, Y.-S., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00317-8 · Cited by 1,447 · see citing works
Shibata, M., Yamada, S., Kumar, S. R., Calero, M., Bading, J., Frangione, B., Holtzman, D. M., Miller, C. A., Strickland, D. K., Ghiso, J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10498 · Cited by 1,413 · see citing works
MCGEER, P., & MCGEER, E. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(95)00011-9 · Cited by 1,287 · see citing works
Astrocyte-endothelial Interactions and Blood-Brain Barrier Permeability*
Abbott, N. J. (2002) · Journal of Anatomy · doi:10.1046/j.1469-7580.2002.00064.x · Cited by 1,168 · see citing works
Cerebral microvascular pathology in aging and Alzheimer's disease
Farkas, E., & Luiten, P. G. M. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00068-x · Cited by 1,102 · see citing works
Microglia and neuroinflammation: a pathological perspective
Streit (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-14 · Cited by 1,039 · see citing works
THE CELL BIOLOGY OF THE BLOOD-BRAIN BARRIER
Rubin, L. L., & Staddon, J. M. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.11 · Cited by 1,005 · see citing works
Complement activation by beta-amyloid in Alzheimer disease.
Rogers, J., Cooper, N. R., Webster, S., Schultz, J., McGeer, P. L., Styren, S. D., Civin, W. H., Brachova, L., Bradt, B., & Ward, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10016 · Cited by 817 · see citing works
Oldendorf, W. H., Cornford, M. E., & Brown, W. J. (1977) · Annals of Neurology · doi:10.1002/ana.410010502 · Cited by 651 · see citing works
Permeability Studies on In Vitro Blood–Brain Barrier Models: Physiology, Pathology, and Pharmacology
Deli, M. A., Ábrahám, C. S., Kataoka, Y., & Niwa, M. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-004-1377-8 · Cited by 643 · see citing works
TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice
Wyss-Coray, T., Lin, C., Yan, F., Yu, G.-Q., Rohde, M., McConlogue, L., Masliah, E., & Mucke, L. (2001) · Nature Medicine · doi:10.1038/87945 · Cited by 587 · see citing works
Blood-brain barrier transport of cytokines: a mechanism for neuropathology
Banks, W. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053381684 · Cited by 534 · see citing works
Tight Junctions of the Blood–Brain Barrier
Kniesel, U., & Wolburg, H. (2000) · Cellular and Molecular Neurobiology · doi:10.1023/a:1006995910836 · Cited by 525 · see citing works
Liebner, S., Fischmann, A., Rascher, G., Duffner, F., Grote, E.-H., Kalbacher, H., & Wolburg, H. (2000) · Acta Neuropathologica · doi:10.1007/s004010000180 · Cited by 490 · see citing works
Immune System Response in Alzheimer's Disease
McGeer, P. L., Akiyama, H., Itagaki, S., & McGeer, E. G. (1989) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100029863 · Cited by 460 · see citing works
Amyloidogenic role of cytokine TGF-β1 in transgenic mice and in Alzheimer's disease
Wyss-Coray, T., Masliah, E., Mallory, M., McConlogue, L., Johnson-Wood, K., Lin, C., & Mucke, L. (1997) · Nature · doi:10.1038/39321 · Cited by 417 · see citing works
Neuroinflammatory processes in Parkinson's disease
Hunot, S., & Hirsch, É. C. (2003) · Annals of Neurology · doi:10.1002/ana.10481 · Cited by 399 · see citing works
Microglia and inflammatory mechanisms in the clearance of amyloid β peptide
Rogers, J., Strohmeyer, R., Kovelowski, C. J., & Li, R. (2002) · Glia · doi:10.1002/glia.10153 · Cited by 381 · see citing works
Kurkowska‐Jastrzębska, I., Wrońska, A., Kohutnicka, M., Członkowski, A., & Członkowska, A. (1999) · Experimental Neurology · doi:10.1006/exnr.1998.6993 · Cited by 379 · see citing works
Bolton, S. J., Anthony, D. C., & Perry, V. H. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00058-x · Cited by 370 · see citing works
Cellular pathology of Parkinson?s disease: astrocytes, microglia and inflammation
Teismann, P., & Schulz, J. B. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0944-0 · Cited by 363 · see citing works
Tarkowski, E., Issa, R., Sjögren, M., Wallin, A., Blennow, K., Tarkowski, A., & Kumar, P. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00285-8 · Cited by 360 · see citing works
Dohgu, S., Takata, F., Yamauchi, A., Nakagawa, S., Egawa, T., Naito, M., Tsuruo, T., Sawada, Y., Niwa, M., & Kataoka, Y. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.027 · Cited by 350 · see citing works
Cell therapy in Parkinson’s disease
Lindvall, O., & Björklund, A. (2004) · NeuroRx · doi:10.1602/neurorx.1.4.382 · Cited by 348 · see citing works
Vogelgesang, S., Cascorbi, I., Schroeder, E., Pahnke, J., Kroemer, H. K., Siegmund, W., Kunert‐Keil, C., Walker, L. C., & Warzok, R. (2002) · Pharmacogenetics · doi:10.1097/00008571-200210000-00005 · Cited by 344 · see citing works
Reduced Glucose Transporter at the Blood‐Brain Barrier and in Cerebral Cortex in Alzheimer Disease
Kalaria, R. N., & Harik, S. I. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07399.x · Cited by 338 · see citing works
Nakayama, M., Uchimura, K., Zhu, R. L., Nagayama, T., Rose, M. E., Stetler, R. A., Isakson, P. C., Chen, J., & Graham, S. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10954 · Cited by 337 · see citing works
Alterations of T-lymphocyte populations in Parkinson disease
Baba, Y., Kuroiwa, A., Uitti, R. J., Wszolek, Z. K., & Yamada, T. (2005) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2005.07.005 · Cited by 336 · see citing works
Microglia and Alzheimer's disease pathogenesis
Streit, W. J. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20093 · Cited by 335 · see citing works
Haseloff, R. F., Blasig, I. E., Bauer, H., & Bauer, H. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-004-1375-x · Cited by 301 · see citing works
Glial cell influence on the human blood‐brain barrier
Prat, A., Biernacki, K., Wosik, K., & Antel, J. P. (2001) · Glia · doi:10.1002/glia.1104 · Cited by 269 · see citing works
Wong, D. K., Dorovini‐Zis, K., & Vincent, S. R. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.08.008 · Cited by 264 · see citing works
Webster, S. D., Lue, L., Brachova, L., Tenner, A. J., McGeer, P. L., Terai, K., Walker, D. G., Bradt, B. M., Cooper, N. R., & Rogers, J. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00042-0 · Cited by 258 · see citing works
THE TIGHT JUNCTION: Morphology to Molecules
Stevenson, B. R., & Keon, B. H. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.89 · Cited by 256 · see citing works
Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys
Judith Miklossy, A., Doudet, D., Schwab, C., Yu, S. Y., McGeer, E. G., & McGeer, P. L. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.10.034 · Cited by 255 · see citing works
A population study on blood-brain barrier function in 85-year-olds
Skoog, I. G., Wallin, A., Fredman, P., Hesse, C., Aevarsson, Ó., Karlsson, I., Gottfries, C. G., & Blennow, K. (1998) · Neurology · doi:10.1212/wnl.50.4.966 · Cited by 238 · see citing works
Transforming growth factor-β1 is in plaques in Alzheimer and Down pathologies
van der Wal, E. A., Gómez‐Pinilla, F., & Cotman, C. W. (1993) · Neuroreport · doi:10.1097/00001756-199301000-00018 · Cited by 230 · see citing works
Mechanisms of the Blood–Brain Barrier Disruption in HIV-1 Infection
Toborek, M. J., Lee, Y. W., Flora, G., Pu, H., Andras, I. E., Wylęgała, E., Hennig, B., & Nath, A. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-004-1383-x · Cited by 228 · see citing works
Tumor Necrosis Factor α Is Toxic to Embryonic Mesencephalic Dopamine Neurons
McGuire, S. O., Ling, Z. D., Lipton, J. W., Sortwell, C. E., Collier, T. J., & Carvey, P. M. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7688 · Cited by 222 · see citing works
Self-citationBlood vessels change in the mesencephalon of patients with Parkinson's disease
Faucheux, B. A., Agid, Y., Hirsch, É. C., & Bonnet, A.-M. (1999) · The Lancet · doi:10.1016/s0140-6736(99)00641-8 · Cited by 218 · see citing works
6-Hydroxydopamine-induced alterations in blood-brain barrier permeability
Carvey, P. M., Zhao, C. H., Hendey, B., Lum, H., Trachtenberg, J., Desai, B. S., Snyder, J., Zhu, Y. G., & Ling, Z. D. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04281.x · Cited by 218 · see citing works
Self-citationFörster, C. Y., Silwedel, C., Golenhofen, N., Burek, M., Kietz, S., Mankertz, J., & Drenckhahn, D. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.084038 · Cited by 212 · see citing works
Cláudio, L. (1995) · Acta Neuropathologica · doi:10.1007/s004010050386 · Cited by 210 · see citing works
Huber, J. D., VanGilder, R. L., & Houser, K. A. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00489.2006 · Cited by 206 · see citing works
Barcia, C., Sánchez-Bahíllo, A., Fernández‐Villalba, E., Bautista‐Hernández, V., Poza, M., Fernández-Barreiro, A., Hirsch, É. C., & Herrero, M. T. (2004) · Glia · doi:10.1002/glia.20015 · Cited by 206 · see citing works
Hartz, A. M. S., Bauer, B., Fricker, G., & Miller, D. S. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.017954 · Cited by 203 · see citing works
Baik, E. J., Kim, E. J., Lee, S., & Moon, C. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01797-7 · Cited by 200 · see citing works
GLUT-1 Expression in the Cerebra of Patients with Alzheimer’s Disease
Mooradian, A. D., Chung, H. C., & Shah, G. N. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00111-5 · Cited by 199 · see citing works
Vascular endothelial growth factor in Alzheimer's disease and experimental cerebral ischemia
Kalaria, R. N., Cohen, D., Premkumar, D. R., Nag, S., LaManna, J. C., & Lust, W. D. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00190-9 · Cited by 190 · see citing works
T-Cells in Alzheimer's Disease
Town, T., Tan, J., Flavell, R. A., & Mullan, M. (2005) · NeuroMolecular Medicine · doi:10.1385/nmm:7:3:255 · Cited by 183 · see citing works
TNF-α knockout and minocycline treatment attenuates blood–brain barrier leakage in MPTP-treated mice
Zhao, C., Ling, Z., Newman, M. B., Bhatia, A., & Carvey, P. M. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.11.012 · Cited by 183 · see citing works
Self-citationThe etiology of Parkinson's disease with emphasis on the MPTP story
Langston, J. W. (1996) · Neurology · doi:10.1212/wnl.47.6_suppl_3.153s · Cited by 180 · see citing works
Furuno, T., Landi, M.-T., Ceroni, M., Caporaso, N., Bernucci, I., Nappi, G., Martignoni, E., Schaeffeler, E., Eichelbaum, M., Schwab, M., et al. (2002) · Pharmacogenetics · doi:10.1097/00008571-200210000-00004 · Cited by 178 · see citing works
Marco, S., & Skaper, S. D. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.03.047 · Cited by 172 · see citing works
Yang, S., Bae, D., Kang, H. J., Gwag, B. J., Gho, Y. S., & Chae, C. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00111-8 · Cited by 170 · see citing works
Microvascular Dysfunction in Sepsis
Lush, C. W., & Kvietys, P. R. (2000) · Microcirculation · doi:10.1038/sj.mn.7300096 · Cited by 166 · see citing works
Progressive Dopamine Neuron Loss in Parkinson's Disease: The Multiple Hit Hypothesis
Carvey, P. M., Punati, A., & Newman, M. B. (2006) · Cell Transplantation · doi:10.3727/000000006783981990 · Cited by 164 · see citing works
Self-citationStructural and Functional Variations in Capillary Systems within the Braina
Fenstermacher, J. D., Gross, P. M., Sposito, N. M., Acuff, V., Pettersen, S. E., & Gruber, K. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb51416.x · Cited by 162 · see citing works
Nanoparticle and other metal chelation therapeutics in Alzheimer disease
Liu, G., Garrett, M. R., Men, P., Zhu, X., Perry, G. L., & Smith, M. A. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.06.006 · Cited by 160 · see citing works
Clinical aspects of inflammation in Alzheimer's disease
Rosenberg, P. B. (2005) · International Review of Psychiatry · doi:10.1080/02646830500382037 · Cited by 159 · see citing works
Clinical Potential of Minocycline for Neurodegenerative Disorders
BLUM, D., CHTARTO, A., TENENBAUM, L., BROTCHI, J., & LEVIVIER, M. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.07.012 · Cited by 157 · see citing works
Fábry, Z., Waldschmidt, M. M., Hendrickson, D., Keiner, J., Love-Homan, L., Takei, F., & HART, M. N. (1992) · Journal of Neuroimmunology · doi:10.1016/0165-5728(92)90026-h · Cited by 155 · see citing works
Role of striatal l ‐DOPA in the production of dyskinesia in 6‐hydroxydopamine lesioned rats
Carta, M., Lindgren, H. S., Lundblad, M., Stancampiano, R., Fadda, F., & Cenci, M. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03696.x · Cited by 150 · see citing works
Cerebral ischemia enhances tyrosine phosphorylation of occludin in brain capillaries
Kago, T., Takagi, N., Date, I., Takenaga, Y., Takagi, K., & Takeo, S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.11.133 · Cited by 136 · see citing works
Gaillard, P. J., van der Sandt, I. C. J., Voorwinden, L. H., Vu, D., Nielsen, J. L., de Boer, A. G., & Breimer, D. D. (2000) · Pharmaceutical Research · doi:10.1023/a:1026406528530 · Cited by 128 · see citing works
Increased intrathecal TGF-β1, but not IL-12, IFN-γ and IL-10 levels in Alzheimer’s disease patients
Rota, E., Bellone, G., Rocca, P., Bergamasco, B., Emanuelli, G., & Ferrero, P. (2006) · Neurological Sciences · doi:10.1007/s10072-006-0562-6 · Cited by 125 · see citing works
Neural Induction of the Blood–Brain Barrier: Still an Enigma
Bauer, H., & Bauer, H. (2000) · Cellular and Molecular Neurobiology · doi:10.1023/a:1006939825857 · Cited by 123 · see citing works
Effect of Oxidative Stress on the Junctional Proteins of Cultured Cerebral Endothelial Cells
Krizbai, I. A., Bauer, H., Bresgen, N., Eckl, P., Farkas, A. E., Szatmari, E. M., Traweger, A., Wejksza, K., & Bauer, H. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-004-1378-7 · Cited by 123 · see citing works
Man, S., Ma, Y., Shang, D., Zhao, W., Li, B., Guo, D., Fang, W., Zhu, L., & Chen, Y. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.02.013 · Cited by 122 · see citing works
Expression of intercellular adhesion molecule 1 (ICAM-1) in Alzheimer’s disease
Frohman, E. M., Frohman, T. C., Gupta, S., de Fougerolles, A., & van den Noort, S. (1991) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(91)90202-i · Cited by 120 · see citing works
Aβ peptide immunization restores blood‐brain barrier integrity in Alzheimer disease
Dickstein, D. L., Biron, K. E., Ujiie, M., Pfeifer, C. G., Jeffries, A. R., & Jefferies, W. A. (2006) · The FASEB Journal · doi:10.1096/fj.05-3956com · Cited by 111 · see citing works
Poduslo, J., Curran, G., Wengenack, T. M., Malester, B., & Duff, K. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0402 · Cited by 111 · see citing works
Phagocytosis of ?/A4 amyloid fibrils of the neuritic neocortical plaques
Wisniewski, H. M., Barcikowska, M., & Kida, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00310142 · Cited by 109 · see citing works
(1994) · PubMed Central · Cited by 105 · see citing works
Blood-brain barrier in Alzheimer dementia and in non-demented elderly
Alafuzoff, I. I., Adolfsson, R., Grundke, I., & Winblad, B. G. (1987) · Acta Neuropathologica · doi:10.1007/bf00693782 · Cited by 104 · see citing works
Neurovascular Pathways and Alzheimer Amyloid β-peptide
Zlokovic, B. V., Deane, R., Sallstrom, J., Chow, N., & Miano, J. M. (2006) · Brain Pathology · doi:10.1111/j.1750-3639.2005.tb00103.x · Cited by 104 · see citing works
Increased cerebrospinal fluid levels of transforming growth factor-β1 in Alzheimer’s disease
Zetterberg, H., Andreasen, N., & Blennow, K. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.06.001 · Cited by 101 · see citing works
Maubant, S., Saint-Dizier, D., Boutillon, M., Perron‐Sierra, F., Casara, P., Hickman, J. A., Tucker, G. C., & Obberghen‐Schilling, E. V. (2006) · Blood · doi:10.1182/blood-2006-05-023580 · Cited by 98 · see citing works
Banks, W. A., Robinson, S. M., Verma, S., & Morley, J. E. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00474-3 · Cited by 90 · see citing works
Tumor necrosis factor-α−308A/G polymorphism is associated with age at onset of Alzheimer's disease
Lio, D., Annoni, G., Licastro, F., Crivello, A., Forte, G. I., Scola, L., Colonna‐Romano, G., Candore, G., Arosio, B., Galimberti, L., et al. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.01.015 · Cited by 84 · see citing works
Parkinson's disease and inflammatory changes
Barcia, C., Barreiro, A. F., Poza, M., & Herrero, M. T. (2003) · Neurotoxicity Research · doi:10.1007/bf03033170 · Cited by 76 · see citing works
Mecocci, P., Parnetti, L., Reboldi, G., Santucci, C., GAITI, A., Ferri, C., Gernini, I., Romagnoli, M., Cadini, D., & Senin, U. (1991) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1991.tb04940.x · Cited by 73 · see citing works
Levodopa with benserazide or carbidopa in Parkinson disease
Rinne, U. K., & Mölsä, P. K. (1979) · Neurology · doi:10.1212/wnl.29.12.1584 · Cited by 70 · see citing works
Vascular Endothelial Growth Factor and Blood-Brain Barrier Disruption in Tuberculous Meningitis
van der Flier, M., Hoppenreijs, S., van Rensburg, A. J., Ruyken, M., Kolk, A. H. J., Springer, P. E., Hoepelman, A. I. M., Geelen, S. P. M., Kimpen, J. L. L., & Schoeman, J. F. (2004) · The Pediatric Infectious Disease Journal · doi:10.1097/01.inf.0000131634.57368.45 · Cited by 70 · see citing works
Alzheimer's disease with and without coexisting Parkinson's disease changes
Gearing, M., Schneider, J. A., Rebeck, G. W., Hyman, B. T., & Mirra, S. S. (1995) · Neurology · doi:10.1212/wnl.45.11.1985 · Cited by 66 · see citing works
Barcia, C., de Pablos, V., Bautista‐Hernández, V., Sánchez-Bahíllo, A., Bernal, I., Fernández‐Villalba, E., Martín, J., Bañón, R., Fernández-Barreiro, A., & Herrero, M. T. (2005) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2005.05.006 · Cited by 63 · see citing works
Jonkers, N., Sarre, S., Ebinger, G., & Michotte, Y. M. (2001) · Journal of Neural Transmission · doi:10.1007/s007020170056 · Cited by 57 · see citing works
Genomewide Association, Parkinson Disease, and PARK10
Farrer, M. J., Haugarvoll, K., Ross, O. A., Stone, J. T., Milkovic, N. M., Cobb, S. A., Whittle, A. J., Lincoln, S., Hulihan, M., Heckman, M. G., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/504728 · Cited by 56 · see citing works
Alzheimer Disease and Its Management
Samanta, M. K., Wilson, B., Santhi, K., Kumar, K. P. S., & Suresh, B. (2006) · American Journal of Therapeutics · doi:10.1097/01.mjt.0000208274.80496.f1 · Cited by 54 · see citing works
Shen, H., Kannari, K., Yamato, H., Arai, A., & Matsunaga, M. (2003) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.199.149 · Cited by 48 · see citing works
Buckwalter, M. S., Coleman, B. S., Buttini, M., Barbour, R., Schenk, D., Games, D., Seubert, P. A., & Wyss‐Coray, T. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2436-06.2006 · Cited by 47 · see citing works
Carvey, P. M., McRae‐Degueurce, A., Lint, T. F., Ptak, L. R., Lo, E. S., Goetz, C., & Klawans, H. L. (1991) · Neurology · doi:10.1212/wnl.41.5_suppl_2.53 · Cited by 47 · see citing works
Self-citationDahlström, A. B., Wigander, A., Lundmark, K., Gottfries, C. G., Carvey, P. M., & McRae‐Degueurce, A. (1990) · Springer eBooks · doi:10.1007/978-3-7091-9050-0_19 · Cited by 47 · see citing works
Self-citationReynolds, D. S., & Morton, A. J. (1998) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(97)00168-4 · Cited by 45 · see citing works
Haglund, M., Kalaria, R. N., Slade, J. Y., & Englund, E. M. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0054-z · Cited by 45 · see citing works
Integrity of the blood–cerebrospinal fluid barrier in early Parkinson's disease
Häussermann, P., Kuhn, W., Przuntek, H., & Müller, T. H. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01574-9 · Cited by 42 · see citing works
Blood vessels and Parkinsonism
Barcia, C. (2004) · Frontiers in Bioscience · doi:10.2741/1145 · Cited by 41 · see citing works
Does Parkinson??s Disease Have an Immunological Basis?
Fiszer, U. (2001) · BioDrugs · doi:10.2165/00063030-200115060-00001 · Cited by 31 · see citing works
Poduslo, J. F., & Curran, G. L. (2001) · Neuroreport · doi:10.1097/00001756-200110290-00011 · Cited by 31 · see citing works
Alzheimer's disease and frontotemporal dementia: prospects of a tailored therapy?
Götz, J., Ittner, L. M., & Schönrock, N. (2006) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2006.tb00615.x · Cited by 26 · see citing works
Nakada, M. T., Tam, S. H., Woulfe, D. S., Casper, K. A., Swerlick, R. A., & Ghrayeb, J. (1998) · Cell Communication & Adhesion · doi:10.3109/15419069809005606 · Cited by 24 · see citing works
Kortekaas, R., Maguire, R. P., Cremers, T. I. F. H., Dijkstra, D., van Waarde, A., & Leenders, K. L. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200405000-00007 · Cited by 22 · see citing works
Endothelial tight junctions form the blood–brain barrier
Bonetta, L. (2005) · The Journal of Cell Biology · doi:10.1083/jcb1693fta1 · Cited by 19 · see citing works
Principles of Treatment in Parkinson's Disease
(2005) · Elsevier eBooks · doi:10.1016/b978-0-7506-5428-9.x5001-x · Cited by 18 · see citing works
Canudas, A. M., Fríguls, B., Planas, A. M., Gabriel, C., Escubedo, E., Camarasa, J., Camins, A., & Pallàs, M. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0308 · Cited by 18 · see citing works
Fillmore, H. L., Holloway, K. L., & Gillies, G. T. (2005) · Neurorehabilitation · doi:10.3233/nre-2005-20309 · Cited by 17 · see citing works
Glucose transport into brain: effects of hypoglycemia.
Simpson, I. A., & Vannucci, S. J. (2002) · PubMed · Cited by 10 · see citing works
The dam breaks: disruption of the blood-brain barrier in diabetes mellitus
Banks, W. A. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00751.2006 · Cited by 8 · see citing works
Carvey, P. M., McRae‐Degueurce, A., Ptak, L. R., Kao, L. C., Lo, E. S., Goetz, C., Tanner, C. M., Penn, R. D., & Klawans, H. L. (1990) · Progress in brain research · doi:10.1016/s0079-6123(08)62661-8 · Cited by 6 · see citing works
Self-citationCann, S. A. H., Netten, J. P. V., & Netten, C. V. (2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200003)47:3
Flagged first, then by citations
Cited by
Sorted by citations
Structure and function of the blood–brain barrier
Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.030 · Cited by 5,185 · see citing works
A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity
Kadry, H., Noorani, B., & Cucullo, L. (2020) · Fluids and Barriers of the CNS · doi:10.1186/s12987-020-00230-3 · Cited by 1,853 · see citing works
Modern methods for delivery of drugs across the blood–brain barrier
Chen, Y., & Liu, L. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.010 · Cited by 1,005 · see citing works
The Blood-Brain Barrier in Brain Homeostasis and Neurological Diseases
Weiss, N., Miller, F., Cazaubon, S., & Couraud, P.-O. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.10.022 · Cited by 731 · see citing works
Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases
Furtado, D., Björnmalm, M., Ayton, S., Bush, A. I., Kempe, K., & Caruso, F. (2018) · Advanced Materials · doi:10.1002/adma.201801362 · Cited by 708 · see citing works
Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease
Shi, M., Liu, C., Cook, T. J., Bullock, K. M., Zhao, Y., Ginghina, C., Li, Y., Aro, P., Dator, R., He, C., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1314-y · Cited by 676 · see citing works
The blood-brain barrier: an engineering perspective
Wong, A. D., Ye, M., Levy, A. F., Rothstein, J. D., Bergles, D. E., & Searson, P. C. (2013) · Frontiers in Neuroengineering · doi:10.3389/fneng.2013.00007 · Cited by 662 · see citing works
Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier
Stamatovic, S. M., Keep, R. F., & Andjelkovic, A. V. (2008) · Current Neuropharmacology · doi:10.2174/157015908785777210 · Cited by 516 · see citing works
Emerging strategies for exploiting cannabinoid receptor agonists as medicines
Pertwee, R. G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00048.x · Cited by 436 · see citing works
Targeting the transferrin receptor for brain drug delivery
Johnsen, K. B., Burkhart, A., Thomsen, L. B., Andresen, T. L., & Moos, T. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101665 · Cited by 372 · see citing works
Role of Blood-Brain Barrier in Alzheimer’s Disease
Cai, Z., Qiao, P.-F., Wan, C.-Q., Cai, M., Zhou, N.-K., & Li, Q. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-180098 · Cited by 370 · see citing works
Immunologic Privilege in the Central Nervous System and the Blood–Brain Barrier
Muldoon, L. L., Alvarez, J. I., Begley, D. J., Boado, R. J., del Zoppo, G. J., Doolittle, N. D., Engelhardt, B., Hallenbeck, J. M., Lonser, R. R., Ohlfest, J. R., et al. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.153 · Cited by 327 · see citing works
Browne, T. C., McQuillan, K., McManus, R. M., O’Reilly, J.-A., Mills, K. H. G., & Lynch, M. A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1200947 · Cited by 322 · see citing works
Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance
Rojo, A. I., McBean, G. J., Cindrić, M., Egea, J., López, M. G., Rada, P., Žarković, N., & Cuadrado, A. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5745 · Cited by 313 · see citing works
Public health and components of particulate matter: The changing assessment of black carbon
Grahame, T. J., Klemm, R., & Schlesinger, R. B. (2014) · Journal of the Air & Waste Management Association · doi:10.1080/10962247.2014.912692 · Cited by 294 · see citing works
Hartz, A. M. S., Bauer, B., Block, M. L., Hong, J., & Miller, D. S. (2008) · The FASEB Journal · doi:10.1096/fj.08-106997 · Cited by 269 · see citing works
Blood-Brain Barrier Disruption by Lipopolysaccharide and Sepsis-Associated Encephalopathy
Peng, X., Luo, Z., He, S., Zhang, L., & Li, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.768108 · Cited by 271 · see citing works
Neurovascular Unit: a Focus on Pericytes
Sá-Pereira, I., Brites, D. M. T. O., & Brito, M. A. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8244-2 · Cited by 267 · see citing works
Prevalence and impact of vascular and Alzheimer pathologies in Lewy body disease
Jellinger, K. A., & Attems, J. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0347-5 · Cited by 265 · see citing works
Liu, W., Wang, Z., Zhang, L., Wei, X., & Li, L. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2012.00340.x · Cited by 258 · see citing works
Theunis, C., Crespo-Biel, N., Gafner, V., Pihlgren, M., López-Deber, M. P., Reis, P., Hickman, D. T., Adolfsson, O., Chuard, N., Ndao, D. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072301 · Cited by 259 · see citing works
“Moreover, in AD and other neurological disorders, the BBB is compromised which might allow antibodies to enter the CNS more readily [47–53].”
BackgroundInflammation and Adaptive Immunity in Parkinson's DiseasePreprint
Mosley, R. L., Hutter-Saunders, J. A. L., Stone, D. K., & Gendelman, H. E. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a009381 · Cited by 246 · see citing works
Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption
Pediaditakis, I., Kodella, K. R., Manatakis, D., Le, C. Y., Hinojosa, C. D., Tien-Street, W., Manolakos, E., Vekrellis, K., Hamilton, G., Ewart, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-021-26066-5 · Cited by 174 · see citing works
Blood-brain barrier alterations in ageing and dementia
Popescu, B. O., Toescu, E. C., Popescu, L. M., Bajenaru, O. A., Muresanu, D. F., Schultzberg, M., & Bogdanović, N. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.02.321 · Cited by 235 · see citing works
Sánchez-Guajardo, V., Barnum, C. J., Tansey, M. G., & Romero‐Ramos, M. (2013) · ASN NEURO · doi:10.1042/an20120066 · Cited by 237 · see citing works
Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review
Bandopadhyay, S., Mandal, S., Ghorai, M., Jha, N. K., Kumar, M., Radha, Ghosh, A., Proćków, J., Pérez de la Lastra, J. M., & Dey, A. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17635 · Cited by 220 · see citing works
Reassessment of subacute MPTP-treated mice as animal model of Parkinson's disease
Zhang, Q.-S., Heng, Y., Mou, Z., Huang, J.-Y., Yuan, Y.-H., & Chen, N.-H. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.49 · Cited by 208 · see citing works
Shi, M., Kovac, A., Korff, A., Cook, T. J., Ginghina, C., Bullock, K. M., Yang, L., Stewart, T., Zheng, D., Aro, P., et al. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.04.003 · Cited by 206 · see citing works
Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy
Blair, L. J., Frauen, H. D., Zhang, B., Nordhues, B. A., Bijan, S., Lin, Y.-C., Zamudio, F., Hernandez, L. D., Sabbagh, J. J., Selenica, M.-L. B., et al. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0186-2 · Cited by 193 · see citing works
Caffeine protects against MPTP‐induced blood‐brain barrier dysfunction in mouse striatum
Chen, X., Lan, X., Roche, I., Liu, R., & Geiger, J. D. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05697.x · Cited by 189 · see citing works
Chen, H.-L., Chen, P.-C., Lu, C.-H., Tsai, N., Yu, C.-C., Chou, K., Lai, Y., Taoka, T., & Lin, W. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/4034509 · Cited by 182 · see citing works
Poller, B., Drewe, J., Krähenbühl, S., Huwyler, J., & Gutmann, H. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9431-1 · Cited by 184 · see citing works
Tau Protein and Its Role in Blood–Brain Barrier Dysfunction
Michalicová, A., Majerová, P., & Kováč, A. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.570045 · Cited by 179 · see citing works
Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases
Kim, S., Jung, U. J., & Kim, S. R. (2024) · Antioxidants · doi:10.3390/antiox13121462 · Cited by 174 · see citing works
Recent Advancements of Nanomedicine in Neurodegenerative Disorders Theranostics
Mukherjee, S., Madamsetty, V. S., Bhattacharya, D., Roy Chowdhury, S., Paul, M. K., & Mukherjee, A. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202003054 · Cited by 152 · see citing works
Physiology of gangliosides and the role of antiganglioside antibodies in human diseases
Cutillo, G., Saariaho, A.-H., & Meri, S. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0388-9 · Cited by 154 · see citing works
Bi, M., Ittner, A., Ke, Y. D., Götz, J., & Ittner, L. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026860 · Cited by 153 · see citing works
Blood–brain barrier alterations and their impact on Parkinson’s disease pathogenesis and therapy
Lau, K., Kotzur, R., & Richter, F. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00430-z · Cited by 165 · see citing works
Zhao, Z., Li, F., Ning, J., Peng, R., Shang, J., Liu, H., Shang, M., Bao, X.-Q., & Zhang, D. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.020 · Cited by 137 · see citing works
Guo, S., & Lo, E. H. (2008) · Stroke · doi:10.1161/strokeaha.108.534388 · Cited by 135 · see citing works
Microglia in Alzheimer’s disease: A multifaceted relationship
ElAli, A., & Rivest, S. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.07.021 · Cited by 134 · see citing works
Chiricozzi, E., Lunghi, G., Biase, E. D., Fazzari, M., Sonnino, S., & Mauri, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030868 · Cited by 129 · see citing works
Wikoff, W. R., Pendyala, G., Siuzdak, G. E., & Fox, H. S. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34138 · Cited by 131 · see citing works
Sarkar, S., Chigurupati, S., Raymick, J. B., Mann, D., Bowyer, J. F., Schmitt, T., Beger, R. D., Hanig, J. P., Schmued, L. C., & Paule, M. G. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.07.006 · Cited by 128 · see citing works
Chung, Y. C., Shin, W.-H., Baek, J. Y., Cho, E. J., Baik, H. H., Kim, S. R., Won, S.-Y., & Jin, B. K. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2015.100 · Cited by 126 · see citing works
Revisiting the blood-brain barrier: A hard nut to crack in the transportation of drug molecules
Harilal, S., Jose, J., Parambi, D. G. T., Kumar, R., Unnikrishnan, M. K., Uddin, M. S., Mathew, G. E., Pratap, R., Marathakam, A., & Mathew, B. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.03.018 · Cited by 124 · see citing works
Role of Immunity and Inflammation in the Pathophysiology of Neurodegenerative Diseases
Fakhoury, M. (2015) · Neurodegenerative Diseases · doi:10.1159/000369933 · Cited by 119 · see citing works
Updates on immunity and inflammation in Parkinson disease pathology
Joshi, N., & Singh, S. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24185 · Cited by 118 · see citing works
Shigemoto‐Mogami, Y., Hoshikawa, K., & Sato, K. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00494 · Cited by 118 · see citing works
Ma, S., Li, Q., Peng, J., Zhouwen, J., Diao, J., Niu, J., Wang, X., Guan, X., Jia, W., & Jiang, W. G. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12764 · Cited by 117 · see citing works
Xiao, M., Xiao, Z. J., Yang, B., Lan, Z., & Fang, F. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00764 · Cited by 113 · see citing works
Palma-Florez, S., López-Canosa, A., Moralez-Zavala, F., Castaño, Ó., Kogan, M. J., Samitier, J., Lagunas, A., & Mir, M. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01798-2 · Cited by 111 · see citing works
Non‐contrast MR imaging of blood‐brain barrier permeability to water
Lin, Z., Li, Y., Su, P., Mao, D., Wei, Z., Pillai, J. J., Moghekar, A., van Osch, M. J. P., Ge, Y., & Lu, H. (2018) · Magnetic Resonance in Medicine · doi:10.1002/mrm.27141 · Cited by 106 · see citing works
Acteoside protects against 6-OHDA-induced dopaminergic neuron damage via Nrf2-ARE signaling pathway
Li, M., Zhou, F., Xu, T., Song, H., & Lu, B. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.06.018 · Cited by 108 · see citing works
ElAli, A., & Rivest, S. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00045 · Cited by 109 · see citing works
Mietelska‐Porowska, A., & Wojda, U. (2017) · Journal of Immunology Research · doi:10.1155/2017/4626540 · Cited by 107 · see citing works
Banik, A., Brown, R. E., Bamburg, J., Lahiri, D. K., Khurana, D., Friedland, R. P., Chen, W., Ding, Y., Mudher, A., Padjen, A. L., et al. (2015) · Journal of Alzheimer’s Disease · doi:10.3233/jad-150136 · Cited by 102 · see citing works
Endothelial Dysfunction in Neurodegenerative Diseases
Fang, Y., Hsieh, Y., Hu, C., & Tu, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032909 · Cited by 101 · see citing works
Neurovascular abnormalities in humans and mice with Huntington's disease
Lin, C.-Y., Hsu, Y.-H., Lin, M.-H., Yang, T.-H., Chen, H.-M., Chen, Y.-C., Hsiao, H.-Y., Chen, C.-C., Chern, Y., & Chang, C. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.08.019 · Cited by 98 · see citing works
Differential receptor-mediated drug targeting to the diseased brain
Rip, J., Schenk, G., & de Boer, A. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240902806383 · Cited by 98 · see citing works
Ali, M., Falkenhain, K., Njiru, B. N., Murtaza-Ali, M., Ruiz‐Uribe, N. E., Haft‐Javaherian, M., Catchers, S., Nishimura, N., Schaffer, C. B., & Bracko, O. (2021) · Brain · doi:10.1093/brain/awab387 · Cited by 97 · see citing works
Cai, S. C. S., Allen, J. C., Lim, Y. L., Chua, S. H., Tan, S., & Tang, M. B. Y. (2013) · British Journal of Dermatology · doi:10.1111/bjd.12806 · Cited by 96 · see citing works
Cerebrospinal fluid proteomics implicates the granin family in Parkinson’s disease
Rotunno, M. S., Lane, M., Zhang, W., Wolf, P., Oliva, P., Viel, C., Wills, A.-M., Alcalay, R. N., Scherzer, C. R., Shihabuddin, L. S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-59414-4 · Cited by 94 · see citing works
Chung, Y. C., Kim, Y.-S., Bok, E., Yune, T. Y., Maeng, S., & Jin, B. K. (2013) · Mediators of Inflammation · doi:10.1155/2013/370526 · Cited by 94 · see citing works
Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models
Carpanini, S. M., Torvell, M., Bevan, R. J., Byrne, R. A. J., Daskoulidou, N., Saito, T., Saido, T. C., Taylor, P. R., Hughes, T. R., Zelek, W. M., et al. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01404-w · Cited by 95 · see citing works
The Role of Neurovascular System in Neurodegenerative Diseases
Ahmad, A., Patel, V., Xiao, J., & Khan, M. M. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02023-z · Cited by 94 · see citing works
Sex differences in the blood–brain barrier and neurodegenerative diseases
Weber, C. M., & Clyne, A. M. (2021) · APL Bioengineering · doi:10.1063/5.0035610 · Cited by 91 · see citing works
Egleton, R. D., Brown, K. C., & Dasgupta, P. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.10.007 · Cited by 91 · see citing works
Exercise and Neuroinflammation in Health and Disease
Seo, D.-Y., Heo, J.-W., Ko, J. R., & Kwak, H.-B. (2019) · International Neurourology Journal · doi:10.5213/inj.1938214.107 · Cited by 88 · see citing works
Characterization of peripheral hematopoietic stem cells and monocytes in Parkinson's disease
Funk, N., Wieghofer, P., Grimm, S., Schäfer, R., Bühring, H., Gasser, T., & Biskup, S. (2013) · Movement Disorders · doi:10.1002/mds.25300 · Cited by 81 · see citing works
Edwards, Y. J. K., Beecham, G. W., Scott, W. K., Khuri, S., Bademci, G., Tekin, D., Martin, E. R., Jiang, Z., Mash, D. C., ffrench‐Mullen, J. M. H., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016917 · Cited by 80 · see citing works
Wang, L., Du, Y., Wang, K., Xu, G., Luo, S., & He, G. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.07.006 · Cited by 78 · see citing works
Mesenchymal stem cells stabilize the blood–brain barrier through regulation of astrocytes
Park, H. J., Shin, J. Y., Kim, H. N., Oh, S. H., Song, S. K., & Lee, P. H. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0180-4 · Cited by 79 · see citing works
Adult neurogenesis, neuroinflammation and therapeutic potential of adult neural stem cells
Taupin, P. (2008) · International Journal of Medical Sciences · doi:10.7150/ijms.5.127 · Cited by 78 · see citing works
Nerves and Neovessels Inhibit Each Other in the Cornea
Ferrari, G., Hajrasouliha, A. R., Sadrai, Z., Ueno, H., Chauhan, S. K., & Dana, R. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8379 · Cited by 75 · see citing works
La Barbera, L., Mauri, E., D’Amelio, M., & Gori, M. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.939855 · Cited by 74 · see citing works
ElAli, A., Thériault, P., Préfontaine, P., & Rivest, S. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-75 · Cited by 72 · see citing works
High prevalence of focal and multi-focal somatic genetic variants in the human brain
Keogh, M. J., Wei, W., Aryaman, J., Walker, L., van den Ameele, J., Coxhead, J., Wilson, I., Bashton, M., Beck, J., West, J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06331-w · Cited by 74 · see citing works
Katt, M. E., Mayo, L. N., Ellis, S., Mahairaki, V., Rothstein, J. D., Cheng, L., & Searson, P. C. (2019) · Fluids and Barriers of the CNS · doi:10.1186/s12987-019-0139-4 · Cited by 69 · see citing works
McCaffrey, G., Seelbach, M. J., Staatz, W. D., Nametz, N., Quigley, C., Campos, C. R., Brooks, T. A., & Davis, T. P. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05582.x · Cited by 71 · see citing works
Kuriakose, M., Rao, K. V. R., Younger, D., & Chandra, N. (2018) · Scientific Reports · doi:10.1038/s41598-018-26813-7 · Cited by 73 · see citing works
Addressing Blood–Brain Barrier Impairment in Alzheimer’s Disease
Sharma, C., Woo, H., & Kim, S. R. (2022) · Biomedicines · doi:10.3390/biomedicines10040742 · Cited by 69 · see citing works
Chen, Y.-R., Lai, P., Chien, Y., Lee, P.-H., Lai, Y., Ma, H., Shiau, C., & Wang, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113807 · Cited by 65 · see citing works
Mechanobiology of the blood-brain barrier during development, disease and ageing
Konig, S., Jayarajan, V., Wray, S., Kamm, R. D., & Moeendarbary, E. (2025) · Nature Communications · doi:10.1038/s41467-025-61888-7 · Cited by 70 · see citing works
Samantaray, S., Knaryan, V. H., Shields, D. C., Cox, A., Haque, A., & Banik, N. L. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9255-6 · Cited by 64 · see citing works
Fuller, O. K., Whitham, M., Mathivanan, S., & Febbraio, M. A. (2020) · Cells · doi:10.3390/cells9102182 · Cited by 60 · see citing works
Non-invasive visualization of CNS inflammation with nuclear and optical imaging
Wunder, A. P., Klohs, J., & Dirnagl, U. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.10.005 · Cited by 64 · see citing works
A glycomics and proteomics study of aging and Parkinson’s disease in human brain
Raghunathan, R., Hogan, J., Labadorf, A. T., Myers, R. H., & Zaia, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-69480-3 · Cited by 63 · see citing works
Nanotechnologies: A Strategy to Overcome Blood-Brain Barrier
Rosa, G. D., Salzano, G., Caraglia, M., & Abbruzzese, A. (2011) · Current Drug Metabolism · doi:10.2174/138920012798356943 · Cited by 61 · see citing works
Current and emerging brain applications of MR-guided focused ultrasound
Meng, Y., Suppiah, S., Mithani, K., Solomon, B., Schwartz, M. L., & Lipsman, N. (2017) · Journal of Therapeutic Ultrasound · doi:10.1186/s40349-017-0105-z · Cited by 60 · see citing works
The Mechanisms of Sevoflurane-Induced Neuroinflammation
Huang, X., Ying, J., Yang, D., Fang, P., Wang, X., Zhou, B., Zhang, L., Yang, F., Yu, W., Liu, X., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.717745 · Cited by 61 · see citing works
Taupin, P. (2009) · Current Alzheimer Research · doi:10.2174/156720509790147151 · Cited by 59 · see citing works
Tauroursodeoxycholic acid (TUDCA) is neuroprotective in a chronic mouse model of Parkinson’s disease
Cuevas, E., Burks, S., Raymick, J., Robinson, B., Gómez-Crisóstomo, N. P., Escudero-Lourdes, C., Lopez, A. G. G., Chigurupati, S., Hanig, J., Ferguson, S. A., et al. (2022) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1859729 · Cited by 57 · see citing works
Sheng, L., Stewart, T., Yang, D., Thorland, E., Soltys, D., Aro, P., Khrisat, T., Xie, Z., Li, N., Liu, Z., et al. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-00983-w · Cited by 56 · see citing works
Bang, S., Lee, S., Choi, N., & Kim, H. N. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002119 · Cited by 55 · see citing works
Gao, X., Xu, J., Yao, T., Liu, X., Zhang, H., & Zhan, C. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114362 · Cited by 55 · see citing works
In Vitro Modeling of the Blood-Brain Barrier: Simplicity Versus Complexity
Ogunshola, O. O. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211797440159 · Cited by 52 · see citing works
Systems biology of neurodegenerative diseases
Wood, L. B., Winslow, A. R., & Strasser, S. D. (2015) · Integrative Biology · doi:10.1039/c5ib00031a · Cited by 54 · see citing works
Choudhury, S. P., Bano, S., Sen, S., Suchal, K., Kumar, S., Nikolajeff, F., Dey, S. K., & Sharma, V. (2022) · npj Parkinson's Disease · doi:10.1038/s41531-022-00324-9 · Cited by 52 · see citing works
Appelt‐Menzel, A., Oerter, S., Mathew, S., Haferkamp, U., Hartmann, C., Jung, M., Neuhaus, W., & Pleß, O. (2020) · Current Protocols in Stem Cell Biology · doi:10.1002/cpsc.122 · Cited by 54 · see citing works
- Authors
- Desai, B. S., Monahan, A. J., Carvey, P. M., & Hendey, B.
- Affiliations
- Department of Pharmacology, Rush University Medical Center, Chicago IL, USA
- Rush University Medical Center (US)
- Venue
- Cell Transplantation
- Publisher
- SAGE Publications
- Published
- 2007-03
- Volume
- 16
- Issue
- 3
- Pages
- 285-299
- ISSN
- 0963-6897 (ISSN-L)
- 1555-3892
- OpenAlex
- W2316522881
- Cited by
- 339
- References
- 117
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 28 · 2023: 31 · 2022: 23 · 2021: 33 · 2020: 37 · 2019: 13 · 2018: 15 · 2017: 16 · 2016: 11 · 2015: 12 · 2014: 12 · 2013: 18 · 2012: 8
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Locations
- Cell Transplantation (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (5r01ns045316-03, W81XWH-04-01-0365)
- U.S. Public Health Service (012307)
- National Institute of Allergy and Infectious Diseases (R01AI051619, R01AI51619)
- National Institute of Neurological Disorders and Stroke (NS045316)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- blood-brain barrier, Alzheimer's disease, Parkinson's disease, BBB dysfunction, tight junctions, blood-brain barrier permeability, neuroinflammation, neurodegeneration, brain drug delivery, vessel density, neurodegenerative disease therapeutics
- MeSH terms
- Alzheimer Disease, Biological Transport, Blood-Brain Barrier, Humans, Parkinson Disease, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review