Significance of brain tissue oxygenation and the arachidonic acid cascade in stroke
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The significance of the hypoxia component of stroke injury is highlighted by hypermetabolic brain tissue enriched with arachidonic acid (AA), a 22:6n-3 polyunsaturated fatty acid. In an ischemic stroke environment in which cerebral blood flow is arrested, oxygen-starved brain tissue initiates the rapid cleavage of AA from the membrane phospholipid bilayer. Once free, AA undergoes both enzyme-independent and enzyme-mediated oxidative metabolism, resulting in the formation of number of biologically active metabolites which themselves contribute to pathological stroke outcomes. This review is intended to examine two divergent roles of molecular dioxygen in brain tissue as (1) a substrate for life-sustaining homeostatic metabolism of glucose and (2) a substrate for pathogenic metabolism of AA under conditions of stroke. Recent developments in research concerning supplemental oxygen therapy as an intervention to correct the hypoxic component of stroke injury are discussed.
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Resting muscle consumes about 1 ml O2 per minute and per 100 g of tissue, but oxygen consumption can increase up to 50-fold in contracting muscle when exercising, enabling enhanced performance.
“Resting muscle consumes ‘only’ 1 ml O2 per minute and per 100 g of tissue, but oxygen consumption can increase up to 50-fold in contracting muscle, when exercising [34], and this enables enhanced performance [35].”
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Tardy, A.-L., Pouteau, E., Marquez, D., Yilmaz, C., & Scholey, A. (2020) · Nutrients · doi:10.3390/nu12010228 · Cited by 541 · see citing works
- Authors
- Rink, C., & Khanna, S.
- Affiliations
- The Ohio State University Wexner Medical Center (US)
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2011-05-15
- Volume
- 14
- Issue
- 10
- Pages
- 1889-1903
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- PMC
- PMC3078506
- OpenAlex
- W2003096217
- Cited by
- 233
- References
- 180
- Citations by year
- 2026: 8 · 2025: 30 · 2024: 35 · 2023: 28 · 2022: 24 · 2021: 24 · 2020: 20 · 2019: 10 · 2018: 8 · 2017: 10 · 2016: 4 · 2015: 10 · 2014: 10 · 2013: 7 · 2012: 3
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS42617, R01NS042617)
- National Center for Research Resources (UL1RR025755)
- Topics
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Keywords
- ischemic stroke, arachidonic acid metabolism, oxygen metabolism, polyunsaturated fatty acids, membrane phospholipids, oxygen therapy, cerebral blood flow, glucose metabolism
- MeSH terms
- Animals, Brain, Brain Ischemia, Humans, Oxygen, Arachidonic Acid, Oxidative Stress, Stroke
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