The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor
Open accessAbstract
Exposure to cyclopamine, a steroid alkaloid that blocks Sonic hedgehog ( Shh ) signaling, promotes pancreatic expansion in embryonic chicks. Heterotopic development of pancreatic endocrine and exocrine structures occurs in regions adjacent to the pancreas including stomach and duodenum, and insulin-producing islets in the pancreas are enlarged. The homeodomain transcription factor PDX1, required for pancreas development, is expressed broadly in the posterior foregut but pancreas development normally initiates only in a restricted region of PDX1-expressing posterior foregut where endodermal Shh expression is repressed. The results suggests that cyclopamine expands the endodermal region where Shh signaling does not occur, resulting in pancreatic differentiation in a larger region of PDX1-expressing foregut endoderm. Cyclopamine reveals the capacity of a broad region of the posterior embryonic foregut to form pancreatic cells and provides a means for expanding embryonic pancreas development.
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Cites
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Cited by
1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
A bipotential precursor population for pancreas and liver within the embryonic endoderm
Deutsch, G., Jung, J., Zheng, M., Lóra, J., & Zaret, K. S. (2001) · Development · doi:10.1242/dev.128.6.871 · Cited by 611
Stromal response to Hedgehog signaling restrains pancreatic cancer progression
Lee, J. J., Perera, R. M., Wang, H., Wu, D.-C., Liu, X. S., Han, S., Fitamant, J., Jones, P. D., Ghanta, K. S., Kawano, S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411679111 · Cited by 502
A small molecule that directs differentiation of human ESCs into the pancreatic lineage
Chen, S., Borowiak, M., Fox, J. L., Maehr, R., Osafune, K., Davidow, L., Lam, K., Peng, L. F., Schreiber, S. L., Rubin, L. L., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.154 · Cited by 478
Self-citationRegulation of pancreas development by hedgehog signaling
Hebrok, M., Kim, S. K., St-Jacques, B., McMahon, A. P., & Melton, D. A. (2000) · Development · doi:10.1242/dev.127.22.4905 · Cited by 412
Self-citation
Metadata
- Authors
- Kim, S. K., & Melton, D. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-10-27
- Volume
- 95
- Issue
- 22
- Pages
- 13036-13041
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2138271428
- Cited by
- 265
- References
- 39
- FWCI
- 15.17
- Type
- journal article
- Language
- en
- Open access
- green
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