The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Gene dosage and stochastic effects determine the severity and direction of uniparental ribosomal RNA gene silencing (nucleolar dominance) in Arabidopsis allopolyploids
Open accessAbstract
Nucleolar dominance is an epigenetic phenomenon in which one parental set of ribosomal RNA (rRNA) genes is silenced in an interspecific hybrid. In natural Arabidopsis suecica , an allotetraploid (amphidiploid) hybrid of Arabidopsis thaliana and Cardaminopsis arenosa , the A. thaliana rRNA genes are repressed. Interestingly, A. thaliana rRNA gene silencing is variable in synthetic Arabidopsis suecica F 1 hybrids. Two generations are needed for A. thaliana rRNA genes to be silenced in all lines, revealing a species-biased direction but stochastic onset to nucleolar dominance. Backcrossing synthetic A. suecica to tetraploid A. thaliana yielded progeny with active A. thaliana rRNA genes and, in some cases, silenced C. arenosa rRNA genes, showing that the direction of dominance can be switched. The hypothesis that naturally dominant rRNA genes have a superior binding affinity for a limiting transcription factor is inconsistent with dominance switching. Inactivation of a species-specific transcription factor is argued against by showing that A. thaliana and C. arenosa rRNA genes can be expressed transiently in the other species. Transfected A. thaliana genes are also active in A. suecica protoplasts in which chromosomal A. thaliana genes are repressed. Collectively, these data suggest that nucleolar dominance is a chromosomal phenomenon that results in coordinate or cooperative silencing of rRNA genes.
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Citations
Cites
The essentials of DNA methylation
Bird, A. (1992) · Cell · doi:10.1016/0092-8674(92)90526-i · Cited by 948
Cited by
Nucleolar dominance: a model for rRNA gene silencing
McStay, B. (2006) · Genes & Development · doi:10.1101/gad.1436906 · Cited by 95
Transgenerational dynamics of rDNA copy number in drosophila male germline stem cells
Lu, K. L., Nelson, J. O., Watase, G. J., Warsinger-Pepe, N., & Yamashita, Y. M. (2018) · eLife · doi:10.7554/elife.32421 · Cited by 77
“…Nucleolar dominance is a phenomenon originally discovered in interspecific hybrids, wherein entire rDNA loci from one species are predominantly activated and those from the other species are silenced (Chen et al., 1998; Chen and Pikaard, 1997; Durica and Krider, 1977; Preuss and Pikaard, 2007).”
BackgroundEpigenetic Regulation of Retrotransposons within the Nucleolus of Drosophila
Eickbush, D. G., Ye, J., Zhang, X., Burke, W. D., & Eickbush, T. H. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01015-08 · Cited by 55
Regulation of Nucleolar Dominance in Drosophila melanogaster
Warsinger-Pepe, N., Li, D., & Yamashita, Y. M. (2020) · Genetics · doi:10.1534/genetics.119.302471 · Cited by 19
Metadata
- Authors
- Chen, Z. J., Comai, L., & Pikaard, C. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-12-08
- Volume
- 95
- Issue
- 25
- Pages
- 14891-14896
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2103856783
- Cited by
- 217
- References
- 1
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Gene dosage and stochastic effects determine the severity and direction of uniparental ribosomal RNA gene silencing (nucleolar dominance) in Arabidopsis allopolyploids. https://app.cochat.ai/papers/10.1073/pnas.95.25.14891
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- Chen, Z. J., Comai, L., & Pikaard, C. S. (1998). Gene dosage and stochastic effects determine the severity and direction of uniparental ribosomal RNA gene silencing (nucleolar dominance) in Arabidopsis allopolyploids. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.25.14891
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