The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Menin, the product of the MEN1 gene, is a nuclear protein
Open accessAbstract
The MEN1 gene, mutations in which are responsible for multiple endocrine neoplasia type 1 (MEN1), encodes a 610-amino acid protein, denoted menin. The amino acid sequence of this putative tumor suppressor offers no clue to the function or subcellular location of the protein. We report herein, based on immunofluorescence, Western blotting of subcellular fractions, and epitope tagging with enhanced green fluorescent protein, that menin is located primarily in the nucleus. Enhanced green fluorescent protein-tagged menin deletion constructs identify at least two independent nuclear localization signals (NLS), both located in the C-terminal fourth of the protein. Among the 68 known independent disease-associated mutations, none of the 22 missense and 3 in-frame deletions affect either of the putative NLS sequences. However, if expressed, none of the truncated menin proteins resulting from the 43 known frameshift/nonsense mutations would retain both the NLSs. The precise role(s) of menin in the nucleus remain to be understood.
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Cites
Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1
Chandrasekharappa, S. C., Guru, S. C., Manickam, P., Olufemi, S.-E., Collins, F. S., Emmert-Buck, M. R., Debelenko, L. V., Zhuang, Z., Lubensky, I. A., Liotta, L. A., et al. (1997) · Science · doi:10.1126/science.276.5311.404 · Cited by 2,082
Self-citationNuclear targeting sequences — a consensus?
Dingwall, C., & Laskey, R. A. (1991) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(91)90184-w · Cited by 1,876
Lemmens, I. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.7.1177 · Cited by 611
Garcia-Bustos, J., Heitman, J., & Hall, M. N. (1991) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(91)90013-m · Cited by 549
Agarwal, S. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.7.1169 · Cited by 477
Somatic mutation of the MEN1 gene in parathyroid tumours
Heppner, C., Kester, M. B., Agarwal, S. K., Debelenko, L. V., Emmert-Buck, M. R., Guru, S. C., Manickam, P., Olufemi, S.-E., Skarulis, M. C., Doppman, J. L., et al. (1997) · Nature Genetics · doi:10.1038/ng0897-375 · Cited by 415
Self-citationSomatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas.
Zhuang, Z., Vortmeyer, A. O., Pack, S., Huang, S., Pham, T. A., Wang, C., Park, W. S., Agarwal, S. K., Debelenko, L., Kester, M. B., et al. (1997) · PubMed · Cited by 294
Self-citationIdentification of MEN1 gene mutations in sporadic carcinoid tumors of the lung
Debelenko, L. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.13.2285 · Cited by 257
Mutations of the MEN1 tumor suppressor gene in pituitary tumors.
Zhuang, Z., Ezzat, S., Vortmeyer, A. O., Weil, R. J., Oldfield, E. H., Park, W. S., Pack, S., Huang, S. C., Agarwal, S. K., Guru, S. C., et al. (1997) · PubMed · Cited by 246
Self-citationNuclear location of the putative transforming protein of avian myelocytomatosis virus
Abrams, H. D., Rohrschneider, L. R., & Eisenman, R. N. (1982) · Cell · doi:10.1016/0092-8674(82)90159-3 · Cited by 240
Cited by
Kaji, H., Canaff, L., Lebrun, J.-J., Goltzman, D., & Hendy, G. N. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061358098 · Cited by 300
Intrinsic Regulators of Pancreatic β-Cell Proliferation
Heit, J. J., Karnik, S. K., & Kim, S. K. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104425 · Cited by 165
Griniatsos, J. E., Dimitriou, N., Zilos, A., Sakellariou, S., Evangelou, K., Kamakari, S., Korkolopoulou, P., & Kaltsas, G. (2011) · World Journal of Surgical Oncology · doi:10.1186/1477-7819-9-6 · Cited by 22
Metadata
- Authors
- Guru, S. C., Goldsmith, P. K., Burns, A. L., Marx, S. J., Spiegel, A. M., Collins, F. S., & Chandrasekharappa, S. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-02-17
- Volume
- 95
- Issue
- 4
- Pages
- 1630-1634
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2063137811
- Cited by
- 434
- References
- 14
- FWCI
- 33.26
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Menin, the product of the MEN1 gene, is a nuclear protein. https://app.cochat.ai/papers/10.1073/pnas.95.4.1630
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- Guru, S. C., Goldsmith, P. K., Burns, A. L., Marx, S. J., Spiegel, A. M., Collins, F. S., & Chandrasekharappa, S. C. (1998). Menin, the product of the MEN1 gene, is a nuclear protein. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.4.1630
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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