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Cleaving DNA with DNA
Open accessAbstract
A DNA structure is described that can cleave single-stranded DNA oligonucleotides in the presence of ionic copper. This “deoxyribozyme” can self-cleave or can operate as a bimolecular complex that simultaneously makes use of duplex and triplex interactions to bind and cleave separate DNA substrates. Bimolecular deoxyribozyme-mediated strand scission proceeds with a k obs of 0.2 min −1 , whereas the corresponding uncatalyzed reaction could not be detected. The duplex and triplex recognition domains can be altered, making possible the targeted cleavage of single-stranded DNAs with different nucleotide sequences. Several small synthetic DNAs were made to function as simple “restriction enzymes” for the site-specific cleavage of single-stranded DNA.
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Citations
Cited by
In Vitro Selection of Functional Nucleic Acids
Wilson, D. S., & Szostak, J. W. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.611 · Cited by 1,206
Li, Y., & Breaker, R. R. (1999) · Journal of the American Chemical Society · doi:10.1021/ja990592p · Cited by 587
Self-citationRecent developments in reversible photoregulation of oligonucleotide structure and function
Lubbe, A. S., Szymanski, W., & Feringa, B. L. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00461j · Cited by 336
An Allosteric Dual-DNAzyme Unimolecular Probe for Colorimetric Detection of Copper(II)
Yin, B.-C., Ye, B.-C., Tan, W., Wang, H., & Xie, C.-C. (2009) · Journal of the American Chemical Society · doi:10.1021/ja9062426 · Cited by 287
Biostable L-DNAzyme for Sensing of Metal Ions in Biological Systems
Cui, L., Peng, R., Fu, T., Zhang, X., Wu, C., Chen, H., Liang, H., Yang, C. J., & Tan, W. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.5b04170 · Cited by 81
Metadata
- Authors
- Carmi, N., Balkhi, S. R., & Breaker, R. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-03-03
- Volume
- 95
- Issue
- 5
- Pages
- 2233-2237
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2142408722
- Cited by
- 262
- References
- 0
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cleaving DNA with DNA. https://app.cochat.ai/papers/10.1073/pnas.95.5.2233
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- Carmi, N., Balkhi, S. R., & Breaker, R. R. (1998). Cleaving DNA with DNA. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.5.2233
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
