The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia
Open accessAbstract
Activated monocytes release a number of substances, including inflammatory cytokines and eicosanoids, that are highly toxic to cells of the central nervous system. Because monocytic infiltration of the central nervous system closely correlates with HIV-1-associated dementia, it has been suggested that monocyte-derived toxins mediate nervous system damage. In the present study, we show that the HIV-1 transactivator protein Tat significantly increases astrocytic expression and release of monocyte chemoattractant protein-1 (MCP-1). Astrocytic release of β-chemokines, which are relatively less selective for monocytes, including RANTES, macrophage inflammatory protein-1α, and macrophage inflammatory protein-1β, was not observed. We also show that MCP-1 is expressed in the brains of patients with HIV-1-associated dementia and that, of the β-chemokines tested, only MCP-1 could be detected in the cerebrospinal fluid of patients with this condition. Together, these data provide a potential link between the presence of HIV-1 in the brain and the monocytic infiltration that may substantially contribute to dementia.
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Cited by
Monocyte Chemoattractant Protein-1 (MCP-1): An Overview
Deshmane, S. L., Kremlev, S., Amini, S., & Sawaya, B. E. (2009) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2008.0027 · Cited by 3,889
Innate immunity in the central nervous system
Ransohoff, R. M., & Brown, M. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58644 · Cited by 1,034
Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1
Gu, L., Tseng, S., Horner, R. M., Tam, C., Loda, M., & Rollins, B. J. (2000) · Nature · doi:10.1038/35006097 · Cited by 832
Mack, M., Kleinschmidt, A., Brühl, H., Klier, C., Nelson, P. J., Cihak, J., Plachý, J., Stangassinger, M., Erfle, V., & Schlöndorff, D. (2000) · Nature Medicine · doi:10.1038/77498 · Cited by 605
Minagar, A., Shapshak, P., Fujimura, R., Ownby, R., Heyes, M., & Eisdorfer, C. (2002) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(02)00207-1 · Cited by 537
Metadata
- Authors
- Conant, K., Garzino-Demo, A., Nath, A., McArthur, J. C., Halliday, W., Power, C., Gallo, R. C., & Major, E. O.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-03-17
- Volume
- 95
- Issue
- 6
- Pages
- 3117-3121
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2027580727
- Cited by
- 577
- References
- 39
- FWCI
- 10.94
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia. https://app.cochat.ai/papers/10.1073/pnas.95.6.3117
- The paper
- Conant, K., Garzino-Demo, A., Nath, A., McArthur, J. C., Halliday, W., Power, C., Gallo, R. C., & Major, E. O. (1998). Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.6.3117
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
