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Cited by 3,889Chemokine receptors and signalingInflammation biomarkers and pathwaysMacrophage Migration Inhibitory Factor

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

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Deshmane, Satish L., Kremlev, Sergey, Amini, Shohreh, Sawaya, Bassel E.·2009·Journal of Interferon & Cytokine Research
DOI 10.1089/jir.2008.0027PMC PMC2755091
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Abstract

Chemokines constitute a family of chemoattractant cytokines and are subdivided into four families on the basis of the number and spacing of the conserved cysteine residues in the N-terminus of the protein. Chemokines play a major role in selectively recruiting monocytes, neutrophils, and lymphocytes, as well as in inducing chemotaxis through the activation of G-protein-coupled receptors. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines that regulate migration and infiltration of monocytes/macrophages. Both CCL2 and its receptor CCR2 have been demonstrated to be induced and involved in various diseases. Migration of monocytes from the blood stream across the vascular endothelium is required for routine immunological surveillance of tissues, as well as in response to inflammation. This review will discuss these biological processes and the structure and function of CCL2.

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  • It is not feasible to assess the sensitivity or specificity of MCP-1 as a biomarker because it has been identified as a chemokine implicated in numerous autoimmune diseases.

    “However, it is not feasible to assess its sensitiveness or specificity as it has been identified as a chemokine implicated in numerous autoimmune diseases [92].”

    From The diagnosis of acute interstitial nephritis caused by infection versus antibiotic-induced interstitial nephritis: a narrative review (2024) · cites this paper as [92]

    The Conclusions and Future Directions section reports a link between CCL2 (MCP-1) polymorphisms and autoimmune diseases, including systemic lupus erythematosus. It does not say that MCP-1’s biomarker sensitivity or specificity cannot be assessed, or that involvement in multiple diseases makes such assessment infeasible. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • MCP-1/CCL2 is decreased at day 1 post-wounding in THS-exposed mouse wounds.

    “In the case of the monocytes we found that MCP-1/CCL2 was decreased at day 1 post-wounding which explains the delayed infiltration of monocytes we see [63].”

    From Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing (2016) · cites this paper as [63]

    The Introduction sections on MCP-1/CCL2 and monocyte recruitment state that CCL2 regulates monocyte infiltration and recruits monocytes to inflamed tissue, supporting the proposed explanation. They do not report a day-1 decrease in MCP-1/CCL2 in THS-exposed mouse wounds; the citing sentence presents that observation as the citing authors’ own finding. No page number is available in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • The decrease in MCP-1/CCL2 explains the delayed infiltration of monocytes in THS-exposed mouse wounds.

    “In the case of the monocytes we found that MCP-1/CCL2 was decreased at day 1 post-wounding which explains the delayed infiltration of monocytes we see [63].”

    From Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing (2016) · cites this paper as [63]

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Cited by

Sorted by citations

Authors
Deshmane, S. L., Kremlev, S., Amini, S., & Sawaya, B. E.
Affiliations
Temple University (US)
Corresponding author
Sawaya, Bassel E.
ORCID
Venue
Journal of Interferon & Cytokine Research
Publisher
SAGE Publications
Published
2009-06
Volume
29
Issue
6
Pages
313-326
ISSN
  • 1079-9907 (ISSN-L)
  • 1557-7465
DOI
10.1089/jir.2008.0027
PMC
PMC2755091
OpenAlex
W2046208657
Cited by
3,889
References
0
Citations by year
2026: 177 · 2025: 267 · 2024: 292 · 2023: 280 · 2022: 389 · 2021: 403 · 2020: 334 · 2019: 294 · 2018: 268 · 2017: 246 · 2016: 202 · 2015: 192 · 2014: 163 · 2013: 115 · 2012: 99
FWCI
7.66
Type
journal article
Language
en
Open access
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations
  • Journal of Interferon & Cytokine Research (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (R01MH070294)
  • National Institute of Neurological Disorders and Stroke (R01NS059327)
Topics
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
  • Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
Keywords
MCP-1, chemokines, CCR2, monocyte migration, chemotaxis, G protein-coupled receptors, monocyte/macrophage infiltration, inflammation
MeSH terms
Animals, Autoimmune Diseases, Chemotaxis, Gene Expression Regulation, Humans, Immunotherapy, Monocytes, Polymorphism, Genetic, Vascular Diseases, Virulence, HIV-1, HIV Infections, Chemokine CCL2, Genetic Predisposition to Disease, Receptors, CCR2

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