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Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy
Abstract
One of the common neurological complications in patients with the acquired immune deficiency syndrome (AIDS) is a subacute encephalopathy with progressive dementia. By using the techniques of cocultivation for virus isolation, in situ hybridization, immunocytochemistry, and transmission electron microscopy, the identity of an important cell type that supports replication of the AIDS retrovirus in brain tissue was determined in two affected individuals. These cells were mononucleated and multinucleated macrophages that actively synthesized viral RNA and produced progeny virions in the brains of the patients. Infected brain macrophages may serve as a reservoir for virus and as a vehicle for viral dissemination in the infected host.
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Cited by
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Dawson, T., & Snyder, S. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05147.1994 · Cited by 1,043
Cytokine-Induced Expression of HIV-1 in a Chronically Infected Promonocyte Cell Line
Folks, T. M., Justement, J., Kinter, A., Dinarello, C. A., & Fauci, A. S. (1987) · Science · doi:10.1126/science.3313729 · Cited by 905
Self-citationHeinzinger, N. K., Bukinsky, M. I., Haggerty, S. A., Ragland, A. M., Kewalramani, V, Lee, M. A., Gendelman, H. E., Ratner, L., Stevenson, M., & Emerman, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7311 · Cited by 854
Self-citationRogers, J., Luber-Narod, J., Styren, S. D., & Civin, W. H. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80079-4 · Cited by 743
Role of Microglia in Central Nervous System Infections
Rock, R. B., Gekker, G., Hu, S., Sheng, W. S., Cheeran, M., Lokensgard, J. R., & Peterson, P. K. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.4.942-964.2004 · Cited by 723
Metadata
- Authors
- Koenig, S., Gendelman, H. E., Orenstein, J. M., Dal Canto, M. C., Pezeshkpour, G. H., Yungbluth, M., Janotta, F., Aksamit, A., Martin, M. A., & Fauci, A. S.
- Venue
- Science
- Published
- 1986-09-05
- Volume
- 233
- Issue
- 4768
- Pages
- 1089-1093
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2030692398
- Cited by
- 1,698
- References
- 0
- FWCI
- 23.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy. https://app.cochat.ai/papers/10.1126/science.3016903
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- Koenig, S., Gendelman, H. E., Orenstein, J. M., Dal Canto, M. C., Pezeshkpour, G. H., Yungbluth, M., Janotta, F., Aksamit, A., Martin, M. A., & Fauci, A. S. (1986). Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy. Science. https://doi.org/10.1126/science.3016903
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