The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Oxidized, deaminated cytosines are a source of C → T transitions in vivo
Open accessAbstract
The most common base substitution arising from oxidative damage of DNA is a GC → AT transition. In an effort to determine the oxidized lesion(s) that gives rise to this mutation, the mutagenicity of three oxidized cytosines, 5-hydroxycytosine, 5-hydroxyuracil, and uracil glycol, were investigated in Escherichia coli . An M13 viral genome was constructed to contain a single oxidized cytosine at a specific site. Replication in vivo of the single-stranded genomes yielded mutation frequencies of 0.05%, 83%, and 80% for 5-hydroxycytosine, 5-hydroxyuracil, and uracil glycol, respectively. The predominant mutation observed was C → T. A model for C → T oxidative mutagenesis is suggested in which initial cytosine oxidation is followed by deamination to a poorly repaired uracil derivative that is strongly miscoding during replication.
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Cites
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Cited by
Oxidative DNA damage and disease: induction, repair and significance
Evans, M. D., Dizdaroglu, M., & Cooke, M. S. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.11.001 · Cited by 1,372
Direct and indirect effects of UV radiation on DNA and its components
Ravanat, J.-L., Douki, T., & Cadet, J. (2001) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(01)00206-8 · Cited by 980
Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells
Barnes, D. E., & Lindahl, T. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.092448 · Cited by 753
Enge, M., Arda, H. E., Mignardi, M., Beausang, J., Bottino, R., Kim, S. K., & Quake, S. R. (2017) · Cell · doi:10.1016/j.cell.2017.09.004 · Cited by 568
Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions
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Self-citation
Metadata
- Authors
- Kreutzer, D. A., & Essigmann, J. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-03-31
- Volume
- 95
- Issue
- 7
- Pages
- 3578-3582
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1966691006
- Cited by
- 310
- References
- 31
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- green
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- Kreutzer, D. A., & Essigmann, J. M. (1998). Oxidized, deaminated cytosines are a source of C → T transitions in vivo. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.7.3578
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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